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Researchers report in a new study that the bacterium Helicobacter pylori - a major contributor to gastritis, ulcers and stomach cancer—resists the body's immune defenses by shutting down energy production within the cells of the stomach lining that serve as a barrier to infection.
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The human stomach is the only known environment where H. pylori exists, Blanke said.
"When any barrier in the human body is colonized by a pathogen, the immune system sets off a series of predictable counterattacks to reclaim the infected space," he said. "H. pylori cripples these immune counterattacks by going straight to the source of a host cell's power to shut down energy production."
Using stomach cells and tissues, the team found that H. pylori manipulates the cell from the outside by sending in a toxin to directly target the mitochondria, which serves as the powerhouse where the cell's energy is produced.
"The toxin disables the mitochondria, resulting in a loss of energy production," Blanke said. "When the cell tries to compensate by reallocating resources from other parts of the cell, a signal is triggered directing the cell to stop production and start breaking things down."
full article here:
https://phys.org/news/2018-05-disease-causing-stomach-bug-energy-host.html
research here:
Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(18)30203-8
Researchers report in a new study that the bacterium Helicobacter pylori - a major contributor to gastritis, ulcers and stomach cancer—resists the body's immune defenses by shutting down energy production within the cells of the stomach lining that serve as a barrier to infection.
"
The human stomach is the only known environment where H. pylori exists, Blanke said.
"When any barrier in the human body is colonized by a pathogen, the immune system sets off a series of predictable counterattacks to reclaim the infected space," he said. "H. pylori cripples these immune counterattacks by going straight to the source of a host cell's power to shut down energy production."
Using stomach cells and tissues, the team found that H. pylori manipulates the cell from the outside by sending in a toxin to directly target the mitochondria, which serves as the powerhouse where the cell's energy is produced.
"The toxin disables the mitochondria, resulting in a loss of energy production," Blanke said. "When the cell tries to compensate by reallocating resources from other parts of the cell, a signal is triggered directing the cell to stop production and start breaking things down."
full article here:
https://phys.org/news/2018-05-disease-causing-stomach-bug-energy-host.html
research here:
Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(18)30203-8
