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Disease-causing stomach bug attacks energy generation in host cells

Discussion in 'Health News and Research unrelated to ME/CFS' started by Sly Saint, May 31, 2018.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    "
    Researchers report in a new study that the bacterium Helicobacter pylori - a major contributor to gastritis, ulcers and stomach cancer—resists the body's immune defenses by shutting down energy production within the cells of the stomach lining that serve as a barrier to infection.

    "
    The human stomach is the only known environment where H. pylori exists, Blanke said.

    "When any barrier in the human body is colonized by a pathogen, the immune system sets off a series of predictable counterattacks to reclaim the infected space," he said. "H. pylori cripples these immune counterattacks by going straight to the source of a host cell's power to shut down energy production."

    Using stomach cells and tissues, the team found that H. pylori manipulates the cell from the outside by sending in a toxin to directly target the mitochondria, which serves as the powerhouse where the cell's energy is produced.

    "The toxin disables the mitochondria, resulting in a loss of energy production," Blanke said. "When the cell tries to compensate by reallocating resources from other parts of the cell, a signal is triggered directing the cell to stop production and start breaking things down."

    full article here:
    https://phys.org/news/2018-05-disease-causing-stomach-bug-energy-host.html

    research here:
    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
    https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(18)30203-8
     
    mango, Inara, sea and 17 others like this.
  2. Mij

    Mij Senior Member (Voting Rights)

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    Yep, I was crawling on the floor by the time I was diagnosed with this infection.
     
  3. Forbin

    Forbin Senior Member (Voting Rights)

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    Fascinating stuff. It's interesting that there even is a toxin that can disable the mitochondria without killing the cell. I wonder what it's called.

    I've occasionally wondered if ME might not be directly caused by a pathogen, but rather by a toxin in the gut (produced by a microbe) which is then somehow getting into the blood stream. I don't know how likely that is, but the indirect route of some molecule harming the cells would explain why no one has consistently found a pathogen in the blood. Once the toxin got out of the gut and into the bloodstream, the disease would be more like poisoning than an infection.
     
    mango, Inara, Skycloud and 5 others like this.
  4. Sisyphus

    Sisyphus Senior Member (Voting Rights)

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    Dunno what toxin that is, but the CDC and Brit Nih did a fine job of shutting down M.E healthcare production without killing stuff that has a constituency.

    Apologies for the rant. I’m sinking, angry and frustrated.
     

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