Development and testing of new vaccines against EBV and other viruses

rvallee

rvallee

Senior Member (Voting Rights)
Moderna appears to be developing several mRNA vaccines for EBV and other viruses

It's an investors' document but it lists several mRNA vaccines in various phases of development for some of the ME-causing viruses: CMV, EBV and some flu strains. CMV appears to be in phase 2 development. EBV could enter phase 1 this year.

ME, or similar chronic illness, is not mentioned as a lifetime risk so they are vastly underestimating the costs and potential benefits.

https://investors.modernatx.com/static-files/834b6509-553f-4ee5-84e0-c198bbb850f0
 
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I've heard about this, but didn't know they were ready for a phase 1 already this year. That's AMAZING! :party::party::party:

I think you are completely right in that the consequences of endemic EBV is very much underestimated.

Imagine if we can see an end of the virus! :woot:
 
In addition to possible future cancer vaccines, there might also be possibilities of combining mRNA technology with CRISPR technology to develop treatments for diseases like cystic fibrosis.
 
Kalliope said:
In addition to possible future cancer vaccines, there might also be possibilities of combining mRNA technology with CRISPR technology to develop treatments for diseases like cystic fibrosis.
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The possibilities are amazing. My memory may be failing me but I think I saw one for asthma in development.

Although there is of course the issue of whether it protects against whatever is the long-X process that can lead to ME and other chronic illness, since preliminary evidence suggests it does not fully protect against LC, although it's still possible that those cases were actually infected and simply asymptomatic.

But it's about time the 2nd book of the germ theory of disease gets written. Pathogens and the immune system are so much more fascinating than what little we know already.
 
The flu mRNA vaccine is beginning its first trial: https://arstechnica.com/science/202...gy-moves-to-flu-moderna-says-trial-has-begun/. It appears to target 4 strains of the virus, which is neat, and apparently two other viruses as well.
"We believe that the advantages of mRNA vaccines include the ability to combine different antigens to protect against multiple viruses and the ability to rapidly respond to the evolution of respiratory viruses, such as influenza, SARS-CoV-2 and RSV," Moderna CEO Stéphane Bancel said in a statement. "Our vision is to develop an mRNA combination vaccine so that people can get one shot each fall for high efficacy protection against the most problematic respiratory viruses."
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I am fairly sure this is a sponsored video for a push by Moderna to market their upcoming vaccines, which appear on track to be multi-purpose and probably standardized in the near future, no reason why multi-pathogen immunizations can't be a standard part of preventative medicine.

I mostly wonder if they will leverage the Long Covid context and also do awareness of the full range of consequences of infectious diseases. It's probably not lost on them that recent evidence suggests humanity will have to take a far more proactive and preventative approach to infectious diseases, the weird notion that it's perfectly OK and reasonable to be regularly sick is just so damn bizarre.

Specifically the video is about chronic health problems caused by cytomegalovirus, the virus with a dinosaur name, when it is passed on in the womb. I didn't know CMV is a major cause of deafness in children. When you see the full range of evidence it's amazing how medicine underestimates the full implications of the germ theory of disease, all because of the damn obsession with Freud's very bad ideas.

 
I think "most cases" is going a bit far. They thought the Incline Village outbreak was EBV until they found that many patients were negative and EBV was not implicated in the ME outbreaks. Every virus has a fingerprint of how it spreads and they did not match that of EBV.
 
Moved post

NIH Launches Clinical Trial of Epstein-Barr-Virus Vaccine

The study will enroll 40 healthy volunteer adults ages 18 to 29 years, half of whom have evidence of prior EBV infection and half of whom do not have evidence of prior EBV infection. Participants will be given a series of three 50-microgram injections of the experimental vaccine in the upper arm muscle, followed by 30 to 60 minutes of observation after each dose. The second and third doses will be administered 30 days and 180 days after the initial dose, with follow-up visits between each vaccination and phone calls between visits. Participation is expected to be required for 18 to 30 months, and the trial is expected to last four years.

https://www.niaid.nih.gov/news-even...=twitter&utm_medium=social&utm_content=202205
 
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Vaccine against Epstein-Barr virus may enter clinical trial next year
German startup plans to test EBV-001 in preventing mononucleosis, MS risk factor
EBViously announced that it has developed a candidate vaccine against the Epstein-Barr virus and plans to bring it into clinical trials starting in 2024.


The company is a spinoff of Helmholtz Munich, part of a German government research network. It is led by scientists with expertise in EBV research working toward a safe and effective vaccine against the virus and the various diseases associated with EBV infection, including multiple sclerosis (MS).

A first clinical trial of the potential vaccine, called EBV-001, will aim to prevent mononucleosis, or mono, and the chronic fatigue it can cause. Mononucleosis due to EBV infection has been linked with a higher risk of MS, and Epstein-Barr is strongly considered a potential factor in disease development.
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https://multiplesclerosisnewstoday....accine-ebv-001-may-enter-clinical-trial-2024/
 
The scientists and manufacturers might also be interested in considering ME.

The article mentions " chronic fatigue syndrome", but in relation to diseases other than Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
 
My understanding is that in Germany, M.E/CFS is still referred to as CFS as far as diagnose goes.

“Based on our very favorable preclinical proof-of-concept data regarding the immunogenicity of the vaccine, we are confident that EBV-001 can effectively prevent the development of infectious mononucleosis and the often associated chronic fatigue syndrome,” said Axel Polack, MD, the company’s CEO.
 
Mij said:
My understanding is that in Germany, M.E/CFS is still referred to as CFS as far as diagnose goes.

“Based on our very favorable preclinical proof-of-concept data regarding the immunogenicity of the vaccine, we are confident that EBV-001 can effectively prevent the development of infectious mononucleosis and the often associated chronic fatigue syndrome,” said Axel Polack, MD, the company’s CEO.
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Yes, thanks. I'm not sure though if their term "chronic fatigue syndrome", refers to chronic fatigue in relation to other illnesses than ME,
or ME/CFS; the confusion and obfuscation we have endured, and fought for decades.

If they are referring to ME/CFS, this would be very good news.
 
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