Covid-19 vaccines and vaccinations

Ischemic Stroke after Bivalent COVID-19 Vaccination: A Self-Controlled Case Series Study (2023, Preprint: MedRxiv, Kaiser Permanente Vaccine Study Center)

With 4933 cases, we found no increased risk within 21-day risk interval across vaccines and by subgroups. However, an elevated risk emerged within 42-day risk interval among individuals <65 years who received co-administration of Pfizer-BioNTech bivalent vaccine and influenza vaccine on the same day; relative incidence (RI) was 2.14 (95% CI, 1.02-4.49). Among those who also had history of SARS-CoV-2 infection, RI was 3.94 (95% CI, 1.10-14.16). After chart review, RIs were 2.35 (95% CI, 0.98-5.65) and 4.33 (95% CI, 0.98-19.11), respectively. Among individuals <65 years who received Moderna bivalent vaccine and had history of SARS-CoV-2 infection, RI was 2.62 (95% CI, 1.13-6.03) before chart review and 2.24 (95% CI, 0.78-6.47) after chart review.
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Our study showed an increased point estimate for the risk of ischemic stroke in a risk interval of 1–42 days only among those aged <65 years who received their PfizerBioNTech bivalent vaccine and influenza vaccine on the same day, although not statistically significant. This finding is unique and may be attributed to differences in the study design compared to previous studies.
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First, our study employed a calendar-based observation period spanning from September 1, 2022, to March 31, 2023. This extended timeframe enabled us to use a longer risk window of 1–42 days following vaccination in addition to the risk interval of 1–21 days in previous studies. Second, we did not exclude individuals with a history of ischemic stroke, but we did apply criteria to increase the likelihood that ischemic stroke events during the study period represented a new ischemic stroke episode. Nevertheless, it is possible that there was interaction between bivalent vaccination and history of ischemic stroke. Furthermore, in subgroup analyses, we considered the influence of history of SARS-CoV-2 infection. SARS-CoV-2 infection is associated with an increased risk of ischemic stroke, and risk factors for SARS-CoV-2 infection may overlap with risk factors for ischemic stroke. There is potential interaction between bivalent vaccination and history of SARS-CoV-2 infection.
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The finding that the point estimate for the risk of ischemic stroke was elevated among individuals aged <65 years but not among individuals aged ≥65 years is also biologically plausible. This may be due to the relatively heightened immune response and subsequent inflammation in the younger age group versus the older age group, and the fact that inflammation has been shown to be associated with an increased risk of ischemic stroke.
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lunarainbows said:
I just got the Autumn booster - which was the “new” Pfizer vaccine (U.K.) - does anyone know, is this the updated one that covers the variants that are currently in circulation?
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It said on my bit of paper that it's been adjusted to take account of the Omicron sub-variants, so I imagine so. They're always going to be one or two steps behind, but it doesn't necessarily make a lot of difference.
 
I wasn’t given any info and because I was distracted by having the Covid as well as the planned flu vaccine I was expecting to have I didn’t think to ask. I had a look on the record I can see online and there wasn’t any detail. I feel like the surgery have got enough on their plate so I will just wait til next time I contact them and try to remember to ask :confused:
 
I think I may of had covid at the beginning of 2020 (jan) but this is before it was official.
It was flu like and reminded me of asthma a bit with the breathing,as this was before official covid I still had the wisdom to keep people away from me saying I had an unusual flu
I never had the vaccine and don’t feel I need it as I don’t usually get infections
I think I may of had covid a few times after that and the only symptom is tinnitus which I’ve never had before
I think it’s made my cfs a bit worse, but it’s not a new thing just a bit more post viral
 
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Trish said:
I had the Phizer one a week ago. It says on the documents I was given that it's XBB 1.5 which is the most updated version available anywhere, I think.
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I had, what I was told, the latest Pfizer booster yesterday. I got it on grounds of age, just scraped it, as I will be 65 next month. My PA got it on the grounds of being my carer (she works with another person with ME too). Had I been a few months younger would have been in the position that my PA would have been eligible and I would not.

So far the injection site is mildly sore and I have a mild headache. Fingers crossed that I will get away with just this, though I have battened down the hatches not needing to open the front door till Monday, partly to allow rest as I have been out twice this week but also to escape Storm Babet. Fortunately we are just in an Amber Warning area here in my bit of the English Midlands. (My heart goes out to anyone with ME subject to natural disaster.)
 
I saw my GP today and he has confirmed that it would be unsafe for me to have another mRNA vaccination. He will ensure it is written in my notes.

He did mention an interesting point, that in 2/3 years the flu and mRNA covid vaccine will be combined into one vaccine. I will need to ensure I have one that is just for flu.

He also mentioned that the vaccine invitations which I continue to get frequently are being sent out by Public Health England, not the NHS, which is why even people who are dead are being called.
 
Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization (2023, Preprint: MedRxiv)
Putrino, Iwasaki et al

In conclusion, people reporting PVS after covid-19 vaccination in this study are highly symptomatic, have poor health status, and have tried many treatment strategies without success. As PVS is associated with considerable suffering, there is an urgent need to understand its mechanism to provide prevention, diagnosis, and treatment strategies.
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ALERT

If you are buying LFTs, check that they are not expired.
I still ask people who are mixing widely to check with an LFT before they see me and provide an LFT if necessary.
We had lots of free ones from when the pandemic was very active but are running out so ordered some from Boots. When Mr B collected them he noticed that over half were past or just on their expiry date. They will need replacing but I never leave the house to do errands so it's more hassle for Mr B. Carers do not need this extra work.
 
I took the Pfizer XBB 1.5 earlier this week (this is sadly outdated already with the variants where I live), a bit sore in the arm but not in a way that made me unable to use it. Got influenza at the same time. Haven't felt much different than usual. My boyfriend got problems lifting his arm where he got the covid vaccine, but it went away in a day although was sore for an additional day.
 
Binkie4 said:
ALERT

If you are buying LFTs, check that they are not expired.
I still ask people who are mixing widely to check with an LFT before they see me and provide an LFT if necessary.
We had lots of free ones from when the pandemic was very active but are running out so ordered some from Boots.
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Yes, and a lot of the free ones issued during the pandemic aren't valid beyond January 2024. I fear I may be having to use mine up over the next few days, anyway :(
 
November 30 blog post by Hilda Bastian about next generation Covid vaccines:

Advancing Past Early Trials – Plus Shooting for Lifelong Immunity (Next Generation Covid Vax Update 12)

https://absolutelymaybe.plos.org/20...immunity-next-generation-covid-vax-update-12/
Hilda Bastian said:
A massive funding boost from Project NextGen enables 3 phase 2b trials of next generation Covid vaccines to start in the US next year, each with 10,000 participants. Another US vaccine is also heading into phase 2 next year. And could “lifelong,” or even decades-long, immunity against Covid be possible? A vaccine aiming for that is heading into its first clinical trial next year, also funded through Project NextGen.

In this update, there is also new clinical trial data for 3 next generation Covid vaccines. Those highlights and more below, are broken down into news from US Project NextGen, and 3 categories of next-generation Covid vaccines (definitions below).
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