Covid-19 vaccines and vaccinations

Thank you @ukxmrv. I have three separate replies to the three yellow cards I filled in. They are identical apart from the different number attached to each response. I spoke to someone once.

I was not given a sheet with possible side effects listed after vaccination and initiated the yellow card response myself due to the severity of the reactions.

I was given a card after each v with the batch number. Before I had the second AZ I had a lengthy call with an immunologist. To me she appeared to be following a script and nothing I could say would lead her to change her advice which was to have the second. I felt very at risk due to health complications and age so went forward.

I need to decide what if anything further to do in relation to the yellow cards. I felt too unwell to pursue it immediately. Now I need to decide how much energy to use on this, a typical ME dilemma.
 
Binkie4 said:
Thank you @ukxmrv. I have three separate replies to the three yellow cards I filled in. They are identical apart from the different number attached to each response. I spoke to someone once.

I was not given a sheet with possible side effects listed after vaccination and initiated the yellow card response myself due to the severity of the reactions.

I was given a card after each v with the batch number. Before I had the second AZ I had a lengthy call with an immunologist. To me she appeared to be following a script and nothing I could say would lead her to change her advice which was to have the second. I felt very at risk due to health complications and age so went forward.

I need to decide what if anything further to do in relation to the yellow cards. I felt too unwell to pursue it immediately. Now I need to decide how much energy to use on this, a typical ME dilemma.
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I didn't get an information sheet with side effects either and no advice on side effects or any warning.

At the clinic I asked what the vaccine was and told it was AstraZeneca. I wasn't told it was the Indian manufactured Covishield. After the vaccine I was given a card with the batch number. Wasn't until after the batch numbers were compared on a Facebook group that I realised what it was.

It wasn't until my husband was given his 2nd dose that an information sheet was given at that clinic.
 
Guillain-Barré-syndrome and Covid-19 vaccines: focus on adenoviral vectors.
COVID-19 vaccination is a life-saving intervention. However, it does not come up without a risk of rare adverse events, which frequency varies between vaccines developed using different technological platforms. The increased risk of Guillain-Barré syndrome (GBS) has been reported for selected adenoviral vector vaccines but not for other vaccine types, including more widely used mRNA preparations. Therefore, it is unlikely that GBS results from the cross-reactivity of antibodies against the SARS-CoV-2 spike protein generated after the COVID-19 vaccination.

This paper outlines two hypotheses according to which increased risk of GBS following adenoviral vaccination is due to (1) generation of anti-vector antibodies that may cross-react with proteins involved in biological processes related to myelin and axons, or (2) neuroinvasion of selected adenovirus vectors to the peripheral nervous system, infection of neurons and subsequent inflammation and neuropathies. The rationale behind these hypotheses is outlined, advocating further epidemiological and experimental research to verify them.

This is particularly important given the ongoing interest in using adenoviruses in developing vaccines against various infectious diseases and cancer immunotherapeutics.
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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183258/full
 
The new XBB.1.16 covid variant, Arcturus, can cause pink eye. Even though this variant is supposed to be new in the U.S., I wonder if it's what my sister contracted in January.

She tested negative for flu and covid, but she had a dreadful cough for 3 weeks and so much diarrhea during that time that she lost an alarming amount of weight. She told me the other day that she also had such bad pink eye with this illness that she had to go to urgent care for just that symptom. So I wonder if this new variant has been in the U.S. longer than researchers think and if covid testing didn't pick up this variant in January.

Of course, she might have had an entirely different illness.
 
Novel Rutgers vaccine may provide more durable protection against SARS-CoV-2

https://www.news-medical.net/news/2...re-durable-protection-against-SARS-CoV-2.aspx

"We need a better vaccine, one that provides years of robust protection with fewer booster shots against a variety of SARS-CoV-2 strains. Our data suggest this vaccine candidate might be able to do that," said Stephen Anderson, associate professor of Molecular Biology and Biochemistry in SAS, resident member of the Rutgers Center for Advanced Biotechnology and Medicine and senior author of the paper in Vaccines.

Existing COVID vaccines often provide some protection against serious disease and death. However, these vaccines typically elicit temporary bursts of protective antibodies that rapidly wane, even after booster doses, leaving most individuals vulnerable to potentially dangerous repeat infections.

This new vaccine, dubbed MT-001, might provide longer-lasting protection against many COVID-19 varieties. "Thankfully, the current vaccines saved many lives, but they're still not optimal in some important respects," said Anderson. "They may not durably prevent people from getting sick."
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Risk assessment of retinal vascular occlusion after COVID-19 vaccination (2023, Nature npj Vaccines)

We matched 739,066 vaccinated cohorts to the unvaccinated cohort at a ratio of 1:1.
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The overall risk of retinal vascular occlusion in the vaccinated cohort was 2.19 times higher than that in the unvaccinated cohort at 2 years.
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The hazards of retinal vascular occlusion and its subtypes were higher within 12 weeks than those at 2 years. Considering the potential acute consequences of COVID-19 vaccinations and its temporary effect, we investigated the bi-weekly incidence of the four forms of retinal vascular occlusion within 12 weeks of COVID-19 vaccination. [...] Cox multivariate analysis showed that the risk of retinal vascular occlusion in the vaccinated group was higher than that in the unvaccinated group at within 2 weeks of vaccination, which persisted for 12 weeks.
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HR for all retinal vascular occlusion types was 3.51 at 2 weeks, peaking at 6.27 at 8-10 weeks.
 
The interesting thing when the nurse called yesterday to book my home visit is that they still didn't understand what M.E was and kept asking me to spell it.

They assume it's FM and are careful not to cause pain when injecting. I don't have pain.
 
Risk of Alzheimer's Disease Following Infuenza Vaccination: A Claims-Based Cohort Study Using Propensity Score Matching

Abstract
Background: Prior studies have found a reduced risk of dementia of any etiology following influenza vaccination in selected populations, including veterans and patients with serious chronic health conditions. However, the effect of influenza vaccination on Alzheimer's disease (AD) risk in a general cohort of older US adults has not been characterized.

Objective: To compare the risk of incident AD between patients with and without prior influenza vaccination in a large US claims database.

Methods: Deidentified claims data spanning September 1, 2009 through August 31, 2019 were used. Eligible patients were free of dementia during the 6-year look-back period and≥65 years old by the start of follow-up. Propensity-score matching (PSM) was used to create flu-vaccinated and flu-unvaccinated cohorts with similar baseline demographics, medication usage, and comorbidities. Relative risk (RR) and absolute risk reduction (ARR) were estimated to assess the effect of influenza vaccination on AD risk during the 4-year follow-up.

Results: From the unmatched sample of eligible patients (n = 2,356,479), PSM produced a sample of 935,887 flu-vaccinated-unvaccinated matched pairs. The matched sample was 73.7 (SD, 8.7) years of age and 56.9% female, with median follow-up of 46 (IQR, 29-48) months; 5.1% (n = 47,889) of the flu-vaccinated patients and 8.5% (n = 79,630) of the flu-unvaccinated patients developed AD during follow-up. The RR was 0.60 (95% CI, 0.59-0.61) and ARR was 0.034 (95% CI, 0.033-0.035), corresponding to a number needed to treat of 29.4.

Conclusion: This study demonstrates that influenza vaccination is associated with reduced AD risk in a nationwide sample of US adults aged 65 and older.
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https://pubmed.ncbi.nlm.nih.gov/35723106/

 
Here are the details of the results:

  • 5.1% of patients who received a flu vaccine developed Alzheimer’s disease.
  • 8.5% of patients who did not receive a flu vaccine developed Alzheimer’s disease.
  • The relative risk for vaccinated individuals was 0.60, or a 40% reduction in the risk of Alzheimer’s disease
Interestingly, this supports other studies that show a decreased risk of Alzheimer’s disease and dementia among individuals who have had various adulthood vaccinations including Tdap (the adult vaccine for tetanus, diphtheria, and pertussis), polio, and herpes zoster (shingles).

According to first author Avram S. Bukhbinder, M.D., a recent alumnus of McGovern Medical School at UTHealth Houston, in a press release issued on June 24, 2022:

The strength of this protective effect increased with the number of years that a person received an annual flu vaccine – in other words, the rate of developing Alzheimer’s was lowest among those who consistently received the flu vaccine every year. Future research should assess whether flu vaccination is also associated with the rate of symptom progression in patients who already have Alzheimer’s dementia.

https://www.skepticalraptor.com/ske...a-40-reduction-in-risk-of-alzheimers-disease/
 
Mij said:
Risk of Alzheimer's Disease Following Infuenza Vaccination: A Claims-Based Cohort Study Using Propensity Score Matching

https://pubmed.ncbi.nlm.nih.gov/35723106/
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A fascinating study, given a similar finding with shingles vaccination. Are we at the point that we can categorically say that the influenza vaccine directly protects against subsequent Alzheimer’s rather than there being something else in the behaviour of people who get vaccines that coincidently protects them from dementia, for example the possibility that people who seek out vaccinations are more likely to eat healthily?

Certainly this looks interesting and reinforces the idea that we still have a lot to learn about the impact of viruses and the role of the immune system.
 
Peter Trewhitt said:
Certainly this looks interesting and reinforces the idea that we still have a lot to learn about the impact of viruses and the role of the immune system.
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It looks really interesting, doesn't it.

I wonder if the fact that numerous vaccines seem to offer some protection may mean it's partly an effect of the immune system being slightly activated, rather than a specific vaccine or infection. I wonder if anyone will follow it up in the years following the pandemic, where large numbers of older people—some of whom might not usually take up vaccines—have had a whole series of mini activations.
 
BioNTech faces first German lawsuit over alleged COVID vaccine side effects

Rogert & Ulbrich says it has filed about 250 cases for clients seeking damages for alleged side-effects of COVID-19 vaccines.

Another law firm, Caesar-Preller, says it is representing 100 cases, with both firms saying separately they cover almost all cases in Germany between them.

A handful of similar cases have been filed in Italy.​
 
Wyva said:
BioNTech faces first German lawsuit over alleged COVID vaccine side effects

Rogert & Ulbrich says it has filed about 250 cases for clients seeking damages for alleged side-effects of COVID-19 vaccines.

Another law firm, Caesar-Preller, says it is representing 100 cases, with both firms saying separately they cover almost all cases in Germany between them.

A handful of similar cases have been filed in Italy.​
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There are cases in the UK going through the legal process. Many people are reporting extremely serious and life changing injuries.
 
Another article from Germany: Post-COVID vaccination syndrome: What do we know?

Like long COVID, post-COVID vaccination syndrome is characterized by a wide variety of symptoms and clinical pictures including chronic fatigue syndrome (CFS/ME), migraines, muscle pain or cardiovascular diseases.

As multifaceted as the symptoms may be, they have one thing in common: They can occur in those affected shortly after COVID vaccination.

Many people think they have post-COVID vaccination syndrome because they developed such symptoms after their shot.

From the point of view of those affected, this is completely understandable, says Harald Prüss from Berlin's Charité hospital and the German Center for Neurodegenerative Diseases (DZNE). But, he adds, just because the symptoms occurred after the shot doesn't mean it caused them.

Prüss explains that post-COVID vaccination syndrome "is totally overestimated in its dimensions."

(...)

Additionally, one of the only ways to say with any degree of certainty that a person is suffering from post-COVID vaccination syndrome rather than long COVID is if that person started experiencing symptoms shortly — weeks, not months — after getting the jab and had not been diagnosed with COVID at any point before. This can be difficult, because people may have had a COVID infection yet not known it.

(...)

Dr. Christine Falk, president of the German Society of Immunology, says the link between long COVID and post-COVID vaccination syndrome could be a cross-reaction with the spike protein — which is created by a vaccine or is an element of it — and the infection itself.

There are some people who, after being infected or vaccinated, not only create normal antibodies against the spike protein, but also experience a sort of cross reaction that produces antibodies that are inadvertently able to recognize endogenous structures — i.e., essential structures created by the body itself. These are called autoantibodies and are present in many people with autoimmune diseases.

That could be why post-COVID vaccination syndrome and long COVID have such similar symptoms.

With all of that said, Falk's idea is only a theory at this point, with much more research needed on the topic.​
 
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