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Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy 1, 2018, Okkersen et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by Lucibee, Jun 20, 2018.

  1. Lucibee

    Lucibee Senior Member (Voting Rights)

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    Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial
    Kees Okkersen, et al.
    Lancet Neurology - 19th June 2018 - Online First



    [Sorry - I'm having terrible trouble with the formatting...
    OK - think I have it sorted now!]
     
    Last edited: Jun 20, 2018
    Sean, Hutan, alktipping and 6 others like this.
  2. Lucibee

    Lucibee Senior Member (Voting Rights)

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    Last edited: Jun 20, 2018
    Sean, Hutan, alktipping and 6 others like this.
  3. Esther12

    Esther12 Senior Member (Voting Rights)

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    Here's that tweet on the 'OPTIMISTIC' group:

    I wonder if they had a prespecified criteria for clinical significance for their DM1-ActivC outcome?

    They mention finding improvement for an objective measure of physical activity in the commentary excerpt.

    Quite a big increase in the number of adverse events with CBT (244 vs 155).

    I shouldn't use this to procrastinate PACE stuff!
     
    alktipping and Invisible Woman like this.
  4. strategist

    strategist Senior Member (Voting Rights)

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    They switched to another primary outcome measure. Unsure about details. They make it sound relatively harmless, and it could be legitimate, but could also be a way to inflate the efficacy of the CBT group. I'm not going to look into it because it doesn't interest me that much, but maybe someone with more interest will want to investigate.
     
  5. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    So what is the point anyway if there was no improvement in quality of life?
     
  6. large donner

    large donner Guest

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    The therapists quality of life will improve immensely sitting working from home nodding every few minutes and drinking coffee and having a fully booked client schedule at £50-£100 an hour. It pays much better than reiki and lets them put to use that little therapy room in the house they set up with all the crystals and dream catchers they hung up when they stopped working in Sainsburys cos that was just too boring.
     
    TiredSam, Sean, Art Vandelay and 9 others like this.
  7. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    Mean (24 h) physical activity (accelerometry [ENMO])† increased by 6.5%.

    Not a big improvement, but acceptable for a adjunct therapy.
     
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  8. Sean

    Sean Senior Member (Voting Rights)

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    If sustained at follow-up.
     
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