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Clinical trials & what we need from them

Discussion in 'BioMedical ME/CFS Research' started by Hip, Mar 27, 2018.

  1. arewenearlythereyet

    arewenearlythereyet Senior Member (Voting Rights)

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    I hear you, but that still doesn’t mean you can quote the research with much confidence...just look at ritixumab ?
    Invisible Woman, Trish and Barry like this.
  2. Hip

    Hip Senior Member (Voting Rights)

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    You may be right regarding the concomitant reduction of viral titers, but other aspects of the enterovirus theory are more established:

    • The findings of chronic enterovirus in ME/CFS patients' tissues: there are numerous studies that have replicated that, and I think that research is unassailable.

    • The fact that enterovirus ME/CFS patients improve on antivirals and immunomodulators like ribavirin, interferon and oxymatrine: that's less well established in terms of published studies, but there are three papers showing interferon improves ME/CFS or puts patients into remission; plus Chia's placebo controlled quasi-study on oxymatrine in 100 ME/CFS patients. (For various reasons, interferon is not a viable long-term treatment; but the fact it works in the short-term provides good evidence that enterovirus plays a causal role in ME/CFS).

    • The concomitant reduction of enterovirus titers as patients improve on the treatment: that is not very well established in published studies (although Chia may have his own data from his clinical work), and further studies are required.
    Last edited: Mar 30, 2018
    Inara and Allele like this.
  3. Alvin

    Alvin Senior Member (Voting Rights)

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    We have lots of evidence that its immune in some form but no confirmation. Its even possible its related to a part of the immune system we do not yet know, if true ME/CFS would not be the first disease that needed a new discovery to become "legitimate"
    Hip likes this.

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