This thread was spilt from : https://www.s4me.info/threads/cbt-jen-brea-twitter.3013/ I am not proposing we make GPs believe anything without evidence to support it. What I would like to see is the UK taking some initiative, by looking at the various treatments used by US doctors, and for those that currently have the strongest evidence base, performing large-scale studies to see if they really do work or not. If all that money which was wasted on the shoddily-performed PACE trial went into decent large scale studies on some of the treatments used in the US, we might by now have some solid evidence. Saying that we currently have no reliable evidence for efficacy is true, but it should not stop there. The preliminary evidence is available, and that should be enough to warrant larger-scale studies to see whether than preliminary evidence pans out or not. That's what happened with rituximab. Rituximab all began on the flimsiest of anecdotal case evidence for efficacy in ME/CFS, but ended up in a large-scale clinical trial. The current evidence base for the efficacy of treatments like Valcyte, Valtrex, Ampligen, oxymatrine, tenofovir, low-dose naltrexone, GcMAF is higher than the original anecdotal evidence for rituximab, so it does not seem right that these treatments have not been pursued in larger-scale studies. I appreciate that the research work on rituximab was down to the highly commendable focused efforts and persistence of Fluge and Mella, along with your own support for this enterprise. Nevertheless, I don't think we should be saying "there is no reliable evidence for the treatments used in the US". In the UK I think we should instead be saying, "there are a lot of promising treatments used in the US, and there is a need to perform large-scale studies on these to properly assess their efficacy".