Thesis Characterising the Electrophysiological Properties of Cells in Health and Disease [on ME/CFS], 2024, Clarke

[ME/CFS Science Blog]

Don't quite understand why figure 32 (below) shows decreases in % change in zeta-potential in ME/CFS patients while on Figure 21 that Murph posted above, it seems that zeta-potential increased after 1.5 hours in the ME/CFS patients.


Figure 32| Normalised ζ-potential data for PBMCs incubated in hyperosmotic NaCl media for 1.5 hours in severe ME/CFS (blue circles: n = 8), mild/moderate ME/CFS (red squares: n = 9), healthy controls (green triangles: n = 6) and MS (purple inverted triangles: n = 4). |A| The change in ζ-potential (%)

 

[petrichor]

Don't quite understand why figure 32 (below) shows decreases in % change in zeta-potential in ME/CFS patients while on Figure 21 that Murph posted above, it seems that zeta-potential increased after 1.5 hours in the ME/CFS patients.

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Figure 32| Normalised ζ-potential data for PBMCs incubated in hyperosmotic NaCl media for 1.5 hours in severe ME/CFS (blue circles: n = 8), mild/moderate ME/CFS (red squares: n = 9), healthy controls (green triangles: n = 6) and MS (purple inverted triangles: n = 4). |A| The change in ζ-potential (%)

I think it's because the zeta-potentials are negative values, and the "Change in zeta-potential" would have been calculated something like: (NaCl zeta potential value minus zeta potential value with no NaCl) divided by zeta potential value with no NaCl. That would give a negative number minus bigger negative number = positive number, then divided by zeta potential value with no NaCl (which is negative). That would give a negative value as a result

Whereas the magnitude changes are just the absolute values of the percent changes