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CFS (PVFS, neurasthenia, ME), (2010 updated 2018) by M Sharpe, chapter in Oxford Textbook of Medicine

Discussion in 'General ME/CFS News' started by Sly Saint, Jan 6, 2019.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

    Messages:
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    Location:
    UK
    Oxford Textbook of medicine (published 2010 but updated 2018):

    Chronic fatigue syndrome (postviral fatigue syndrome, neurasthenia, and myalgic encephalomyelitis)
    Chapter:
    Chronic fatigue syndrome (postviral fatigue syndrome, neurasthenia, and myalgic encephalomyelitis)
    Author(s):
    Michael Sharpe
    DOI:
    10.1093/med/9780199204854.003.260504
    Chronic fatigue syndrome (CFS) is also known as postviral fatigue syndrome, neurasthenia, and myalgic encephalomyelitis. All describe an idiopathic syndrome characterized by disabling fatigue and other symptoms occurring chronically and exacerbated by minimal exertion.

    Aetiology and pathogenesis—it is likely that multiple factors operate to predispose, precipitate, and perpetuate CFS: (1) predisposing factors—some individuals may be predisposed to develop CFS by virtue of genetics, personality, or other vulnerability; (2) precipitating factors—the condition may be precipitated by factors such as infection or psychological stresses;

    (3) perpetuating factors—for practical management the most important factors are those that perpetuate the illness and consequently act as barriers to recovery, including modifiable psychological, biological, behavioural, and social factors. Studies have reported a variety of biological abnormalities: few have been confirmed, but the most robust are (1) altered brain function, and (2) reduced hypothalamic-pituitary-adrenal axis responsiveness, although it is not clear if these are primary or secondary to inactivity...."

    (bolding mine)

    http://oxfordmedicine.com/view/10.1093/med/9780199204854.001.1/med-9780199204854-chapter-260504
     
    Last edited by a moderator: Jan 6, 2019
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  2. TiredSam

    TiredSam Moderator Staff Member

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    9,838
    Location:
    Germany
    perpetuating factors—for practical management the most important factors are those that perpetuate the illness and consequently act as barriers to recovery, including the unmodifiable behaviour of Michael Sharpe and colleagues.
     
  3. JemPD

    JemPD Senior Member (Voting Rights)

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    Amen!
     
    Trish, MEMarge, Barry and 1 other person like this.
  4. chrisb

    chrisb Senior Member (Voting Rights)

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    Hmm.… perpetuating factors. That would be things like secondary gain. Strange how these ideas crop up in the discussion of conversion disorder and hysteria.
     
    rvallee, Amw66, Trish and 1 other person like this.

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