"Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia... van Campen et al, 2020

[Hutan]

@tralfamadorian97, we have a thread for study ideas. A later paper by the van Campen team is mentioned as needing replication on it:

Ideas arising from a recent van Campen study:

• undertake analysis of cerebral brain flow (CBF) and cardiac output (CO) upon orthostatic challenge in all ME/CFS patients, not just those reporting orthostatic symptoms and not just those with a normal HR and BP response to tilt testing.
• compare CBF and CO measurements on good and bad days
• investigations into the mechanisms of the CBF and CO reductions
• investigations of possible treatments, including compression garments and drugs with a plausible mechanism
• validate the CBF measurement technique of extracranial Doppler flow
• replicate the study using different methods of measurement of CBF
• more studies on non-cerebral blood flow in relation to orthostatic stress and good day/bad day comparisons e.g. is there blood pooling?
• differences in ME/CFS severity, in males and females

Thread here:cerebral blood flow relation is abnormal in most ME/CFS patients with a normal heart rate and blood pressure response, 2024, van Campen et al