Review [+ Case Report] [POT] With [CF] After HPV Vaccination as Part of the “Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants”, 2014, Tomljenovic+

Yann04

Yann04

Senior Member (Voting Rights)
Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the “Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants”

Tomljenovic, Lucija; Colafrancesco, Serena; Perricone, Carlo; Shoenfeld, Yehuda

Abstract
We report the case of a 14-year-old girl who developed postural orthostatic tachycardia syndrome (POTS) with chronic fatigue 2 months following Gardasil vaccination. The patient suffered from persistent headaches, dizziness, recurrent syncope, poor motor coordination, weakness, fatigue, myalgias, numbness, tachycardia, dyspnea, visual disturbances, phonophobia, cognitive impairment, insomnia, gastrointestinal disturbances, and a weight loss of 20 pounds. The psychiatric evaluation ruled out the possibility that her symptoms were psychogenic or related to anxiety disorders. Furthermore, the patient tested positive for ANA (1:1280), lupus anticoagulant, and antiphospholipid. On clinical examination she presented livedo reticularis and was diagnosed with Raynaud’s syndrome. This case fulfills the criteria for the autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA). Because human papillomavirus vaccination is universally recommended to teenagers and because POTS frequently results in long-term disabilities (as was the case in our patient), a thorough follow-up of patients who present with relevant complaints after vaccination is strongly recommended.

Web | DOI | PMC | PDF | Journal of Investigative Medicine High Impact Case Reports
 
I know this is old, but I‘m wondering if this kind of thing could be why some people report „complex chronic illness“ following COVID vaccine.

(Of course its really hard to tell what seems genuine or what seems a couple anecdotes pushed out of proportion given the politics around vaccines today).
 
I had the worst crash ever 5 days after my 3rd Pfizer covid vaccine. This could be intriguing if anyone could ever work out a mechanism from this that fits into that timeframe.
 
Is the timing of the development of lupus, that of two months post HPV vaccination--does that make clinical sense if implicating the vaccination as causative?

There's always the possibility that she developed lupus and the history of being vaccinated has no relevance. What is the background rate of lupus incidence and what is the background rate of lupus incidence w/HPV vaccination?

Of particular note: one author gives expert testimony for vaccine injury cases in the courts and another is from the Dwoskin Family Foundation, a pseudo-science anti-vaccine group (see Wikipedia: Children's Medical Safety Research Institute).
 
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