Blood flow in sepsis and ME/CFS

An interesting blog post. It argues that sepsis and ME/CFS have in common what is called “heterogeneous perfusion”.

There is a picture of what that looks like.


According to the blog, this would explain many of the characteristics of ME/CFS.

https://www.syndromea.org/2019/02/10/blood-flow-in-sepsis-and-me-cfs/

 

This is interesting, thanks for posting. I have long thought that impaired blood flow can explain almost all our symptoms.

 

any comments @Jonathan Edwards ?

Does this make sense

 

This blog called "Syndrome A" currently has 4 posts. https://www.syndromea.org/

1. On Autism & Chronic Fatigue Syndrome
2. Why Does ME/CFS Look Like Sepsis?
3. Blood Flow in Sepsis and ME/CFS
4. ME/CFS, Sepsis & Glycocalyx
   

Posts 1 and 3 are discussed separately in the following threads, in different sub-forums ("Methylation; B12; Glutathione; GcMAF" and "Cardiovascular and Respiratory"):
https://www.s4me.info/threads/syndrome-a-on-autism-chronic-fatigue-syndrome.6480/#post-117926
https://www.s4me.info/threads/blood-flow-in-sepsis-and-me-cfs.8103/

I feel the blog deserves a more general discussion. It is essentially about an overarching hypothesis centered on blood vessels. Post 2 gives an overview (long read).

First impressions (I haven't been able to do a focussed read yet, just a quick skim):

The author has read a lot of research.
The author has done a lot of thinking.
The author is asking a lot of good questions.

Here is an interesting excerpt from post 4.

Could this glycocalyx damage explain PEM?

Could these DAMPS molecules be the mystery factor in the blood that makes healthy cells behave like ME cells when placed into ME plasma?

 

"Full-on advert" is an understatement! But it did teach me how to pronounce 'glycocalyx'.

Interesting to know that there is a technology widely used in research, at least according to the ad, to look at blood flow in the microvascular system. Would it be suitable to look at blood flow issues in ME, too?