Biomedicine & Pharmacotherapy: CFS: Suggestions for a nutritional treatment in the therapeutic approach - Geir Bjørklund et al - 2018

Kalliope

Kalliope

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Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach

Abstract
Chronic fatigue syndrome (CFS) is known as a multi-systemic and complex illness, which induces fatigue and long-term disability in educational, occupational, social, or personal activities. The diagnosis of this disease is difficult, due to lacking a proper and suited diagnostic laboratory test, besides to its multifaceted symptoms. Numerous factors, including environmental and immunological issues, and a large spectrum of CFS symptoms, have recently been reported. In this review, we focus on the nutritional intervention in CFS, discussing the many immunological, environmental, and nutritional aspects currently investigated about this disease. Changes in immunoglobulin levels, cytokine profiles and B- and T- cell phenotype and declined cytotoxicity of natural killer cells, are commonly reported features of immune dysregulation in CFS. Also, some nutrient deficiencies (vitamin C, vitamin B complex, sodium, magnesium, zinc, folic acid, l-carnitine, l-tryptophan, essential fatty acids, and coenzyme Q10) appear to be important in the severity and exacerbation of CFS symptoms. This review highlights a far-driven analysis of mineral and vitamin deficiencies among CFS patients.
 
The etiology of CFS is unknown; however, observations suggest that there may be at least two different etiological subgroups. One subgroup consists of patients with early, often undiagnosed Parkinson’s disease [40] and may have further degenerative brain diseases [41], while the other subgroup appears to be composed of patients with various low-grade, but chronic infections or inflammations, including infections with herpesvirus-6, Epstein-Barr virus and various enteroviruses [[42], [43], [44], [45], [46]].
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I’ve not heard of a large undiagnosed Parkinson’s subgroup in ME. Is this nonsense? The reference is in Russian (which doesn’t mean it’s nonsense, but it does mean I can’t read the original).
 
Supradyn is mentioned specifically as well as other general things. I wonder why? Amazon product ASIN B00EWKWP5W
It’s from this study
Multivitamin mineral supplementation in patients with chronic fatigue syndrome
Daniela Maric, Snezana Brkic, Slavica Tomic, Aleksandra Novakov Mikic, Tatjana Cebovic, Vesna Turkulov

(Novi Sad, Serbia)

Med Sci Monit 2014; 20:47-53

DOI: 10.12659/MSM.889333

Published: 2014-01-14




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Background: Chronic fatigue syndrome (CFS) is characterized by medically unexplained persistent or reoccurring fatigue lasting at least 6 months. CFS has a multifactorial pathogenesis in which oxidative stress (OS) plays a prominent role. Treatment is with a vitamin and mineral supplement, but this therapeutic option so far has not been properly researched.
Material and Methods: This prospective study included 38 women of reproductive age consecutively diagnosed by CDC definition of CFS and treated with a multivitamin mineral supplement. Before and after the 2-month supplementation, SOD activity was determined and patients self-assessed their improvement in 2 questionnaires: the Fibro Fatigue Scale (FFS) and the Quality of Life Scale (SF36).
Results: There was a significant improvement in SOD activity levels; and significant decreases in fatigue (p=0.0009), sleep disorders (p=0.008), autonomic nervous system symptoms (p=0.018), frequency and intensity of headaches (p=0.0001), and subjective feeling of infection (p=0.0002). No positive effect on quality of life was found.
Conclusions: Treatment with a vitamin and mineral supplement could be a safe and easy way to improve symptoms and quality of life in patients with CFS.
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https://www.medscimonit.com/download/getFreePdf/l/EN

Did those researchers gain anything from trialling a specific multivitamin?
 
The main author is norwegian, but I've never heard of him or this CONEM council before. Please take a look at this "Council for Nutritional and Environmental Medicine (CONEM)" - it's not a public entity. It's founded by the main author, who also is the president:

http://www.conem.org/people/bjorklundbio/

He also have:

Björklund Nutrition is an online, global news service. It features news and resources focused on nutrition, environmental medicine, and health. The service is founded and managed by Geir Bjørklund

http://www.bjorklundnutrition.net/

It's says in the bio that he's an independent researcher, but don't seem to have done any actual research? Or have any medical background, that I can see? All it mentions is beeing an editor and a dental journal he founded?

Maybe I'm missing someting...? But a look at his publication list, is seems to be all review articles? (that I suspect are more like opinion pieces....?)
 
I did some more digging.

The contact adress for "CONEM" seems to be the same as Geir Bjørklund's private home. At the same adress he has another company registered - Bjørklund Pharma AS.

Björklund Pharma is a new and ambitious pharmaceutical company based in Norway (organization number NO 914 768 934). It develops and markets dietary supplements, natural preparations, and cosmetics based on reliable scientific evidence
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http://www.bjorklundpharma.com/


Edit: Corrected last name, had written "Bjørkmo" one place - correct is Bjørklund.
 
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