Biomedical Insights that Inform the Diagnosis of ME/CFS - Brett Lidbury and Paul Fisher 2020

Sly Saint · Feb 9, 2020

Received: 6 February 2020; Accepted: 6 February 2020; Published: 8 February 2020

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It is well known that myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS), whether considered as separate diseases or as the one chronic syndrome, continue to generate debate. Discussions on language, definitions and theoretical parameters continue, but whatever your position, one can now agree that ME and/or CFS (referred to hereafter as ME/CFS) is a disease with a physiological basis, rooted in biochemical and molecular dysfunction in the cells of sick individuals, and not attitudes that can be alleviated by psychological therapies.

As a result, biomedical imperatives must now become the focus of research enquiry in order to find clinically translatable answers as soon as possible.
This book is intended as a landmark volume to mark this shift in thinking and to consolidate recent fundamental discoveries and biomedical insights as pathways towards tangible diagnostics, and eventual ME/CFS treatments. Australian researchers, with their collaborators locally and abroad, have been at the forefront of discovery in the biomedical realm, and this book draws together fundamental and applied insights that have emerged from scientific and clinical enquiry.
The consolidation of up-to-date insights into ME/CFS was catalysed by a conference (https://www.emerge.org.au/symposium#.XbIv2iVS-3c) in March 2019 (Geelong, Australia), hosted by Emerge Australia, and several chapters in this volume are based on presentations from this meeting.
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Concluding Remarks
To reiterate, this book, as a Special Issue of the MDPI journal Diagnostics, stands as a landmark to consolidate the extent and value of biomedical research into ME/CFS, and associated clinical observations. Another metaphor may be a “rallying point”, especially for those who have accepted the physiological basis of ME/CFS, but have been discouraged by ongoing disagreement among the research community and health professionals. In spite of debate, the evidence presented here and elsewhere provides sufficient impetus to explore ME/CFS as a biomedical challenge that can be solved.

Guided by the journal title, all contributors were encouraged to focus on elements within their research or practice that emphasised diagnostic utility and innovation. Having succeeded in presenting a collection of manuscripts spanning patient experience to pathology, physiology to molecular and cellular biology, we hope that this publication invites further insights from biomedical science, and finally acceptance that ME/CFS is a true disease with physiological foundations.
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Biomedical Insights that Inform the Diagnosis of ME/CFS - MDPI

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=12&cad=rja&uact=8&ved=2ahUKEwj9zaGR2cTnAhVkTxUIHY_WDHsQFjALegQICRAB&url=https%3A%2F%2Fwww.mdpi.com%2F2075-4418%2F10%2F2%2F92%2Fpdf&usg=AOvVaw16MD1oWAA1bFfY8Z2bNh--

eta: journal link
https://www.mdpi.com/2075-4418/10/2/92

S-VV · Feb 10, 2020

This is great. I would love more commentary on the CNS pathology and excess glutamatergic tone (think Jay Goldstein) but it’s great nontheless, as much for biomed advances as for PR.

wastwater · Apr 20, 2020

I just read someone quoting DR Goldstein saying NMDA is Involved M.E not sure if it’s true but I’m interested

mariovitali · Apr 20, 2020

Can you post a link please ? Very interested as well , to say the least

wastwater · Apr 20, 2020

https://www.healthrising.org/forums/resources/dr-goldsteins-resurrection-cocktail.342/

adambeyoncelowe · Apr 20, 2020

wastwater said: ↑

https://www.healthrising.org/forums/resources/dr-goldsteins-resurrection-cocktail.342/
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I would take it all with a grain of salt. Ketamine isn't something to play around with.

My ex's heart stopped on that stuff on a night out. The paramedics had to restart it outside the club. (We were only about 19. I'm sure he wouldn't be that silly now.)

I've never understood why people take it willingly.

ETA: Goldstein is just another in a long line of people who claim to have 'the secret' and make outlandish claims. I don't buy it.

If the treatments worked, then there would be people whom it doesn't work for too--especially because we won't all have the exact same thing.

And why hasn't he put anything to the test in a study? Even a survey of his patients to show absolute numbers would be a start.

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