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Autoantibodies to Beta-Adrenergic and Muscarinic cholinergic receptor in ME patients - Bynke, Bergquist et al -2020

Discussion in 'BioMedical ME/CFS Research' started by Kalliope, Jul 22, 2020.

  1. Kalliope

    Kalliope Senior Member (Voting Rights)

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    Full title
    Autoantibodies to Beta-Adrenergic and Muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – a validation study in plasma and cerebrospinal fluid from two Swedish cohorts

    Journal
    Brain, Behavior, & Immunity - Health

    Authors
    Annie Bynke, Per Julin, Carl-Gerhard Gottfries, Harald Heidecke, Carmen Scheibenbogen, Jonas Bergquist

    Highlights
    Myalgic Encephalomyelitis (ME) is a devastating disorder (with millions of patients worldwide) with unclear etiology and no clear diagnostic biomarker available.

    This study support previous findings that there exists a general pattern of increased antibody levels to adrenergic and muscarinic receptors within the ME patient group.

    No evidence for intrathecal antibody production was found in cerebrospinal fluid. The role of increased autoantibodies in the pathogenesis of ME is still uncertain and further research is needed to evaluate the clinical significance of these findings.
     
    Anna H, Michelle, JaneL and 20 others like this.
  2. Trish

    Trish Moderator Staff Member

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  3. Hutan

    Hutan Moderator Staff Member

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    Here's the main chart. Red is for controls, the green and blue are for two patient samples. The various autoantibodies are on the x-axis. The differences look a bit underwhelming in terms of being a cause of ME/CFS symptoms.

    Screen Shot 2020-07-23 at 10.45.29 AM.png
     
    Anna H, Simon M, Michelle and 16 others like this.
  4. Milo

    Milo Senior Member (Voting Rights)

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    Thank you for sharing @Kalliope. May i ask that you fix the typo in the title to read ‘beta’ and not ‘beat’? :whistle:
     
  5. Sid

    Sid Senior Member (Voting Rights)

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    The scatterplot looks like there's nothing there to hang your hat on.
     
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  6. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    Yes, I'm not going to get excited about this one.
     
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  7. Amw66

    Amw66 Senior Member (Voting Rights)

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    Did they separate out POTS comorbidities ?
     
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  8. Kalliope

    Kalliope Senior Member (Voting Rights)

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    Oops. Thanks for spotting that @Milo !
     
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  9. butter.

    butter. Senior Member (Voting Rights)

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    b1 seems significant.
     
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  10. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

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    The statistical (Wilcoxon) tests did show some significant differences after Bonferonni corrections, most clearly for the M4-Musc-Receptor. Unfortunate that the authors don't report results for the two patient cohorts taken together.

    This, however, suggests that the small differences were not that important clinically:
     
    Anna H, Caesar, Simon M and 11 others like this.

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