@Jonathan Edwards Sorry to trouble you. That response is very interesting. I suspect most of us who have been referred to specialists will, at some time, have been asked whether parents or siblings have suffered from anything similar, and will generally have answered "no". Do you think that your response has implications for the question that should be put? Could having a parent with, say, ankylosing spondylitis, increase ones risk for developing an idiopathic ME type illness, and should the possibly relevant conditions be specified? I suspect that most patients would not realise that AS in a parent might be relevant to the answer.