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Association between C-reactive protein and chronic fatigue syndrome: a meta-analysis, 2017, Wang et al

Discussion in 'BioMedical ME/CFS Research' started by Andy, Dec 17, 2017.

  1. Andy

    Andy Committee Member & Outreach

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    Hampshire, UK
    For what its worth.
    PDF download, http://www.ijcem.com/files/ijcem0053166.pdf
    Inara, MEMarge, Helen and 8 others like this.
  2. Woolie

    Woolie Committee member

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    These results are pretty consistent, imo. When they isolated those studies that used high sensitivity CRP assays, every single one showed a trend towards higher CRP in the ME patients vs. controls.

    The difference is pretty tiny, which suggests that it might be driven by a subset of patients.

    One potential problem is that its unclear just from the paper whether all studies controlled for BMI. This is a pretty strong predictor of CRP levels so you need to control for that.

    But if you think its great new biomedical evidence validating the existence of ME, then think again. An association has also been shown between CRP and depression (independently of BMI), and the psychosocial people believe that its the bad thoughts causing the inflammation.

    We need to be prepared for when the BPS crowd start to get with the inflammation trend (which they will, its only a matter of time)
    Inara, Mij, Valentijn and 14 others like this.
  3. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    The problem with non-specific tests is findings with poor specificity...
    Inara and Valentijn like this.

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