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Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in ME/CFS, Almenar-Perez et al. 2020

Discussion in 'ME/CFS research' started by John Mac, Feb 7, 2020.

  1. John Mac

    John Mac Senior Member (Voting Rights)

    Full Title:
    Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome


    Hutan, Aroa, sb4 and 16 others like this.
  2. InfiniteRubix

    InfiniteRubix Senior Member (Voting Rights)

    Earth, in a fractal universe
    Sample of 30 . 15 severe from biobank+15 controls

    Great to see biobank fuelled work!
    Hutan, Dolphin, Simone and 8 others like this.
  3. cassava7

    cassava7 Senior Member (Voting Rights)

    How are these findings related to the cytokine analysis of extracellular vesicles that Maureen Hanson presented at the 3rd OMF symposium last September? She hadn’t found any significant difference in the average size or concentration of total EVs in ME/CFS patients vs healthy controls, but different cytokine associations. I guess my question is, is there any link here? :)

    Glad to see new findings about EVs and something that points towards exosomes!

    Edit: Maureen Hanson’s presentation:


    she starts talking about EVs at the 9:50 ish mark.

    Edit2: Some EV size and count differences:

    Last edited: Feb 7, 2020
    Simone and alktipping like this.
  4. FMMM1

    FMMM1 Senior Member (Voting Rights)

    I'm interested in their findings; however, I wonder if we would be better focusing on the GWAS study @Simon M has been involved in promoting. From memory a GWAS study may give us clues regarding causes. This study could potentially identify consequence e.g. if the small exosomes (increased in ME) come from a particular tissue --- then that might provide a clue to where to focus research. I suppose both have their place; however, considering these results are not remarkable, then I'd like the results of the GWAS study! E.g. I've been interested in a potential link to thyroid function in ME, a GWAS study might turn up something interesting regarding genes controlling thyroid function.

    Some extracts from this paper
    "lower levels for alkaline phosphatase and free thyroid hormone T4 levels"
    "hormonal glands (mostly thyroid)"
    "we find, following a database search formerly described by our group56, that hsa-miR-18a-5p can be upregulated by the anti-psychotic drug desipramine, while hsa-miR-146a-5p and hsa-miR-150-5p expression can be induced by morphine56, raising the possibility that the observed overexpression of these miRNAs derives from patient drug exposure and not from the disease itself. This highlights the enormous importance of detailed medication registry when studying molecular changes in these patients, as recommended by the ME/CFS NINDS CDEs46."
    Kitty and ukxmrv like this.

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