Article: Spain, "Lleida scientists discover a marker that allows diagnosing chronic fatigue [syndrome]"

Andy

Senior Member (Voting rights)
Relying on a Google translate for the English translation. I haven't been able to find the paper this is based on, assuming there is one.
A group of researchers from the Institute for Research in Biomedicine (IRB Lleida) have led a pioneering study on chronic fatigue syndrome, a diagnosis difficult disease that affects between 500 and 1,000 Lleida. Specifically, the study points out the use of oxygen as a possible biomarker in the diagnosis of the disease. This is the first time that a scientific biomarker is proposed that can help diagnose chronic fatigue, known as invisible disease , since at present all blood tests give a negative result. According to the researchers, this biomarker shows the existence of a possible disorder in the production of energy by the mitochondria of the muscle cells of these patients.

The IRB study led by rheumatologist Lluís Rosselló (hospital of Santa Maria) and Joan Anton Prat Subirana (president of Andromeda Foundation). The conclusions were presented last Saturday, at the 7th National Conference on Sports Medicine, held in Zaragoza. The presentation was given by Dr. Fernando Pifarré, professor of biomechanics at the University of Lleida and director of the Sports Medicine Service of the Generalitat in the capital of Ponent.
https://translate.google.com/transl...ica_33770_1092.html?__twitter_impression=true

Original article
https://amp.segre.com/noticies/llei...t_diagnosticar_fatiga_cronica_33770_1092.html

I saw this on Anil's Facebook blog page
Code:
https://www.facebook.com/AnilaboutME/posts/1942405466021364
 
Still not found the actual paper but found this article from a year ago (but it still doesn't really tell us much).
The group of patients involved participated in a series of functional tests (heart rate, respiratory, etc.) and it was found that the increasing fatigue they felt could be related to the fact that they did not get enough oxygen to the muscle cells The head of the specialized Unit of the hospital of Santa Maria pointed out that they are still preliminary results that we must continue working, just like they are doing in other hospital centers such as Vall d'Hebron in Barcelona.

In any case, he emphasizes that "the line is good and it will probably lead to developing drugs that go well for the disease, we are studying it."
Google translate - https://translate.google.co.uk/tran...crear/farmacs/fibromialgia&edit-text=&act=url

Original link - https://www.naciodigital.cat/lleida...lleida/obre/portes/crear/farmacs/fibromialgia
 
Still this seems like it could be a helpful study as my understanding was that previous studies had not found the differences on the 2nd day but not the first...I may be wrong on that...

But to me the more studies that find lack of energy production in cells the better to keep building the evidence against Psychosocial models and increase the movement towards biomedical research to find out why mitochondrial dysfunction is occurring
 
How is this any different from a normal 2 day exercise test?
From your Facebook post it says:
They measured the O2 levels in the patients muscle cells during an ergospirometry test and found very low markers that shows that there is a possible disruption in energy production in these people with ME cells. They also point out that this same marker is usually very high in elite athletes (those who usually perform this type of test).
The CPET and ergospirometry wouldn't measure O2 levels in muscle cells, so it's possible they were testing something additional as well. Or they might be making assumptions and/or inferring muscle involvement based on CPET/spirometry results.

The article specifically says (translated) :
It is a great finding when diagnosing the disease, because until now there was no marker in blood analysis that could certify the chronic fatigue syndrome, that is to say, the diagnosis could not be completely confirmed.
This suggests they were taking blood samples during or after the CPET, which is not a normal part of a CPET. And they might be referring specifically to blood gas analysis (instead of more general blood tests), which would include oxygen levels. So I suspect that there is a new finding here, though it's possible other groups have done something similar, such as the Lights.

They're an interesting group, doing sport physiology research. But instead of the usual "exercise is great for everyone" stuff, they're looking at dangers of exercise, such as with Cardiological contraindications in sports earlier this year:

Recommendations
The objective of this review is to summarize the main anomalies and heart disease that can be found in athletes and aims to give a recommendation and general pattern of steps to follow in the case of recommendation of the cardiological aptitude for sports taking the main groups of heart disease, i.e.: cardiomyopathies (table 3), valvular heart and aorta (table 4), arrhythmias and channelopathies (table 5), and congenital heart disease (table 6). For each of the alterations a recommended intensity is given depending on the type of recreational or competitive sport exercise. In order to simplify this indication a red color was granted when competitive sport is contraindicated and recreational sport is permitted if a low static component (Mitchell I) and is carried out at a lower intensity than 60% maximum heart rate or less than 5 Borg Scale; a yellow color is granted only when the competitive sport is allowed in sports classification of Mitchell IA (i.e.: golf, bowling) and recreational sport is permitted if it is a low-moderate static component (Mitchell I and II) and carried out at a lower intensity than 75% maximum heart rate or less than 6 Borg Scale. However, it is noteworthy that the decision should always be individualized and customized according to the severity of the disease, comorbidities of the subject, mode and sport that is practiced and, importantly, personal environment of the subject.

Unfortunately they seem to publish primarily in Spanish, which is going to limit the audience of the data they present.
 
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https://translate.google.com.au/translate?sl=auto&tl=en&js=y&prev=_t&hl=en&ie=UTF-8&u=http://scielo.isciii.es/scielo.php?pid=S1135-57272016000100206&script=sci_arttext&tlng=en&edit-text=&act=url

"Stressful Events in the Onset of Chronic Fatigue Syndrome"

Iraida Gimeno Pi 1 , Mª Luisa Guitard Sein-Echaluce 2 , Lluís Rossello Aubach 3 , Joan Torres Puig-Gros 4 , Joaquim Fernández Solà 5 Lleida Spain
Am I right in thinking that this is a different publication by them?
 
Deepl.com can’t do whole web page translations but is very good for translating stuff. Their translation of this seems to read better for me but my biology knowledge is minimal so I don’t know if it provides any more information than the google translate version.
 
Looks a bit mixed.
Am wondering what "hippo" therapy is? Possibly lost in translation or probably better left to the imagination.


Unless there's another "hippotherapy," it's a form of Equine-assisted therapy. ["Hippo" is Greek for horse, as in "hippodrome." Hippopotamus actually means "river horse.")
Hippotherapy involves an occupational therapist, a physiotherapist, or a speech and language therapist working with a client and a horse. Different movements of the horse present challenges to the client to promote different postural responses of the client by the horse influencing the client rather than the client controlling the horse.[5] The word "Hippotherapy" is also used in some contexts to refer to a broader realm of equine therapies. -
https://en.wikipedia.org/wiki/Equine-assisted_therapy


From the article, it sounds like horse-riding is used as a form of physical therapy. I would assume that for ME patients it would be little more than sitting on a walking horse. That would still be a form of exertion for the rider. It almost sounds like it is being used in lieu of a treadmill.
This is a study on the treatment of chronic fatigue through hippotherapy. A series of functional tests (heart rate, respiratory rate, etc.) were performed on the group of patients who participated and it was found that the increasing fatigue they felt could be related to the fact that not enough oxygen was reaching the muscle cells.


I could see the use of horses for physical therapy being a fairly common option in Spain.


[If I'm wrong about all this, I'm going to be very embarrassed!:)]





 
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