Are unexplained adverse health events following HPV vaccination associated with infectious mononucleosis?, 2020, Krogsgaard et al

[Dolphin]

https://www.sciencedirect.com/science/article/pii/S0264410X20308434#!

Vaccine
Available online 2 July 2020


Are unexplained adverse health events following HPV vaccination associated with infectious mononucleosis? – A Danish nationwide matched case-control study
Lene Wulff KrogsgaardaIda GlodeHelmuthbBodil HammerBechaOleguerPlana-RipollcTina HovgaardLützenaHanne ThangVestergaarddKarsten DalsgaardBjerreeReimar WernichThomsenfKåreMølbakghDorteRyttera
a
Research Unit for Epidemiology, Department of Public Health, Aarhus University, Denmark
b
Department of Infectious Diseases Epidemiology, Statens Serum Institut, Copenhagen, Denmark
c
National Centre for Register-based Research, Department of Economics and Business Economics, Aarhus University, Denmark
d
Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark
e
Division of Infectious Disease Preparedness, Data Analysis and Integration, Statens Serum Institut, Copenhagen, Denmark
f
Department of Clinical Epidemiology, Aarhus University Hospital, Denmark
g
Division of Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark
h
Department of Veterinary and Animal Sciences, University of Copenhagen, Denmark
Received 3 February 2020, Revised 12 June 2020, Accepted 18 June 2020, Available online 2 July 2020.

https://doi.org/10.1016/j.vaccine.2020.06.057
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Abstract
Background
In Denmark, the acceptance of the HPV vaccination program has been threatened by reports of suspected adverse events. Epstein Barr Virus (EBV) infection is associated with symptoms of long-lasting tiredness and may be misinterpreted as HPV vaccine adverse events. The main aim of this study was to examine if EBV infection around time of HPV vaccination was a risk factor for later suspected vaccine adverse events.

Methods
The study was a nationwide register-based matched case-control study. Cases were females vaccinated against HPV in the period 2011 throughout 2017 with suspected adverse events. For each case, five HPV vaccinated females without suspected adverse events were selected. Information about EBV infection was obtained from the Danish Microbiology Database and assessed for three time periods: (1) before first HPV vaccination, (2) around time of HPV vaccination, and (3) any time during the study period 2010–2017. Multiple logistic regression was used to estimate the association between EBV and suspected adverse events.

Results
We identified 1217 cases, matched to 6085 controls. A higher proportion of cases (38; 3.1%) than controls (31; 0.5%) were tested for EBV around time of HPV vaccination and cases had elevated odds for testing both EBV positive (OR 4.52, 95% CI 2.68–7.63) and EBV negative (OR 20.99, 95% CI 5.81–75.79). Only five females were classified with acute/recent EVB infection in this period.

Conclusion
Misinterpretation of EBV infection late symptoms is not a leading explanation for Danish females experiencing suspected adverse events after HPV vaccination. Although EBV cannot be excluded as an explanatory factor for a very small proportion of suspected adverse events, the findings are more likely explained by protopathic bias, i.e. the fact that a larger proportion of females suspecting adverse events are tested for EBV.

Keywords
HPV vaccination
Mononucleosis
Epstein Barr Virus infection
Suspected adverse events
Register-based
Case-control study

 

[Hoopoe]

Maybe they got something else that causes a suspicion of mono, a suspicion of adverse reaction to a vaccine, and some serious illness.

 

[alktipping]

it is possible that the conveyer belt system of mass vaccinations leads to people who are already fighting an infection receiving a vaccination when they shouldn't . after all the protocol of not proceeding with injection or other method when there are signs of some other infection has been known for decades but you know time = money so why listen to a child who says they feel unwell just before the vaccine is administered . also many people can be asymptomatic when receiving vaccines and then their symptoms show up after the vaccine is in their eyes the most likely culprit . would it be to expensive to screen vaccine recipients beforehand .

 

[Sisyphus]

it is possible that the conveyer belt system of mass vaccinations leads to people who are already fighting an infection receiving a vaccination when they shouldn't . after all the protocol of not proceeding with injection or other method when there are signs of some other infection has been known for decades but you know time = money so why listen to a child who says they feel unwell just before the vaccine is administered . also many people can be asymptomatic when receiving vaccines and then their symptoms show up after the vaccine is in their eyes the most likely culprit . would it be to expensive to screen vaccine recipients beforehand .

Huh. I thought it was standard practice to not off a vax while a person is feverish, even if they ‘want to get it done today’. Then again, rules seem to garner little respect these days.

 

[Sisyphus]

Wellll, N of 1 and all, but I decided to get the HPV shot despite having M.E., we’re in a low risk for that stuff but high risk for vaccines. But I tolerate the flu shot, so I thought I’d try it. Result: The next day, I felt exactly as worn out as I always do. And the day after, and the day after the day after...
HPV vx is protective for 2 cancer causes, it seems like a good trade to me.