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Abnormal rheological properties of red blood cells as a potential marker of Gulf War Illness: A preliminary study, 2018, Condon et al

Discussion in ''Conditions related to ME/CFS' news and research' started by Andy, Apr 21, 2018.

  1. Andy

    Andy Committee Member

    Hampshire, UK
    Paywalled at https://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch170262
  2. Daisymay

    Daisymay Senior Member (Voting Rights)

    Ron Davis and co seem to be finding the opposite with ME, reduced deformability:

    OMF-funded research: red blood cell deformability in ME/CFS
    March 21, 2018


    On this #OMFScienceWednesday, we present a new project that we are funding that will evaluate the ‘deformability’ of red blood cells as a potential biomarker for ME/CFS. Red blood cells (RBCs) are the most common cells in the blood. Their main role is to transport oxygen and carbon dioxide in the blood, and this role depends in part on their ‘deformability’ / elasticity as they flow through small blood vessels. Alterations in RBC deformability have been associated with inflammation and diseases like sepsis, and some studies suggest that RBC damage occurs in ME/CFS. These observations along with new technology available for measuring RBC deformability prompted Dr. Ron Davis’ team at Stanford and their collaborators at San Jose State University to examine RBC deformability in ME/CFS.

    In some very early data generated by this team, there are indications that RBC deformability is reduced in some ME/CFS patients. The ME/CFS RBCs tested so far seem to move more slowly and elongate less than healthy controls, according to tests with this new technology. We are funding a project to confirm these findings in additional patients, and to study RBCs using additional methods, including various types of advanced microscopy, to better understand why these differences exist. If these experiments are successful, they may establish a new biomarker for ME/CFS that could assist in diagnosis and possibly finding new treatments! Stay tuned for more.

    Learn more about RBCs in this Khan Academy video:


  3. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

    Les Simpson found altered blood shapes in ME too. This may, if true, distinguish the two illnesses (although obviously a history of service in the Gulf War is a big giveaway in most cases), but it's such a tiny sample size I'm not sure it's accurate. I'm inclined to think RBCs should be similar in both illnesses.
    ukxmrv, Manganus and Daisymay like this.
  4. Amw66

    Amw66 Senior Member (Voting Rights)

  5. Amw66

    Amw66 Senior Member (Voting Rights)


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