A university went to great lengths to block the release of information about a trial gone wrong. A reporter fought them and revealed the truth.

Andy

Andy

Retired committee member
Sorry, not PACE.

Here’s a story that shows the lengths a public university — The University of Illinois at Chicago — went to block the release of information about a child psychiatry trial gone wrong, and how a reporter — Jodi S. Cohen of ProPublica — fought them effectively at every turn to reveal the truth.

Earlier this year, ProPublica “revealed that the National Institute of Mental Health ordered the university to repay $3.1 million in grant money it had received to fund [Mani] Pavuluri’s study.” This kind of clawback is very, very rare.
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https://retractionwatch.com/2018/07...-reporter-fought-them-and-revealed-the-truth/
 
There was a programme on the BBC recently about antidepressents in children and it covered one where the medication was causing more problems. After getting the clinical trial data released it was discovered that there was actually no benefit of using the medication in children and it was actually quite dangerous. researchers got hold of 77,000 pages of previously undisclosed data from the Paxil study. They reanalyzed the original trial findings and published their results in 2015. Paxil, they found, was not only ineffective in treating adolescent depression when compared to placebo—it was dangerous. The paper that was published by the drug company though they hadn't focussed on these issues!

While just looking for info on this I found this article which lists other similar cases https://academic.oup.com/bmb/article/116/1/43/400796
 
Sbag said:
There was a programme on the BBC recently about antidepressents in children and it covered one where the medication was causing more problems. After getting the clinical trial data released it was discovered that there was actually no benefit of using the medication in children and it was actually quite dangerous. researchers got hold of 77,000 pages of previously undisclosed data from the Paxil study. They reanalyzed the original trial findings and published their results in 2015. Paxil, they found, was not only ineffective in treating adolescent depression when compared to placebo—it was dangerous. The paper that was published by the drug company though they hadn't focussed on these issues!

While just looking for info on this I found this article which lists other similar cases https://academic.oup.com/bmb/article/116/1/43/400796
Click to expand...
Yes, i watched this.
Two points that sunk in were

Little research had actually been done on the effect and efficacy of these drugs in children and adolescents - the use had been largely justified based on effect in adults ( developing brains are different)
Note that this is not uncommon generally.

The one drug that was effective was not that that tended to be prescribed.

Lack of info given to parents and adolescents re side effects was also highlighted- most were left to read the patient information leaflet inside the drug box....
 
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