Discussion in 'BioMedical ME/CFS Research' started by Dolphin, Jul 19, 2019.
This research was funded or part funded by Invest in ME research
Oh dear - "postexternal malaise (PEM)"
Hope it's right elsewhere in the document.
I want transcriptome data from the gut of patients in PEM, to look at proteins involved with instestinal barrier function. It's not just bacteria that can affect this. And from my own experience when I've been very ill and had other cook for me (if I managed to eat) the diet has not always been gut microbiome friendly to say the least.. I haven't got the energy to read through this now (ironicly reading about leaky gut, diet and IBD for work), but how do they take this into account?
Have to hope this is a simple typo, and that is not really what they believe it is called! I wonder if someone can alert them to this.
Interesting, the concepts of a leaky gut and disordered gut bacteria used to be laughed at by allopathic medicine. Or, at least cause eye rolling. Now, this topic is getting more and more attention. Thank goodness!
Just my own experiences, but there does seem to be a correlation between an increase in GI issues, and brain fog. When my GI problems/pain flare, the brain fog worsens. Too much fibre or carbs, can both cause GI problems to increase, which after experiencing this hundreds if not thousands of times over the decades, appears to lead directly to increased brain fog.
During gradual onset, my IBS became much more painful.
ETA: just added a bit more info.
Hi @Andy, do you have an email for Quadram/Simon C?
Just done a search - there's an email address for
Daniel Vipond here:
There might be correlations between "leaky gut" and a more leaky blood-brain-barrier, that could perhaps cause brain-fog?
Do you still need it?
No, I can email him. Thanks
@MeSci and @Andy
Just got an email from Daniel V thanking us for pointing this out. He is contacting the UAE library to correct this and also going to have a read thro' the rest to check, now that he has a bit more time.
Simon Carding's talk at IiMER covered his PhD. Hopefully, that will be out soon, as the Anne Ortegren memorial lecture is now on Youtube, hopefully the rest will follow.
Daniel also said:
"Part of this work, however, has been submitted for publication based on faecal metabolomics data and a targeted mass-spec analysis of bile acids. I hope this will be available soon. "
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