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https://escientificlibrary.com/nutritional-health/Article/ESJNH-V1-1008.pdf
https://escientificlibrary.com/nutritional-health/Article/ESJNH-V1-1008.pdf
A Proposal for Explaining Progression from Light/Moderate to Severe
Chronic Fatigue
Review Article
Anna Dorothea Höck*
Internal Medicine in Albertus-Magnus University in Cologne, Germany
Received: Apr 30, 2020; Accepted: June 09, 2020; Published: June 11, 2020
*Corresponding author: Anna Dorothea Höck, Internal Medicine in Albertus-Magnus University in Cologne, Germany
Abstract
Background:
Chronic mild to moderate fatigue is also called chronic idiopathic fatigue.
Physicians at best consider about psychotherapy for treatment.
But most physicians do not view this condition as a real disease.
In contrast, debilitating chronic severe disease has been termed chronic fatigue syndrome (CFS), or if more severe, myalgic encephalopathy (CFS/ME).
Meanwhile published metabolic aberrations in CFS/ME suggest estimating these diseases no longer as mere psychiatric diseases.
The metabolic results inspire to further exploration of cell stress response mechanisms, which are summarized in this paper.
Interestingly, cell stress responses were tightly linked to vitamin D3-mediated effects, such as homeostatic regulation of metabolism, energy and redox balance, as well as defense against pathogens and toxins.
Specific personality traits, prevalence of indoor activities, latitude and climate predispose to vitamin D3 deficiency, which is supposed to represent a missing link for a comprehensive model of disease progression from mild chronic fatigue to most severe forms.
By diagnosing vitamin D deficiency in early stages of chronic fatigue, the progression to severe and debilitating chronic fatigue may be prevented.
In more severe stages of chronic fatigue, such as CFS/ME, resistance against mere vitamin D replenishment seems to be the rule.
Some causal mechanisms for this resistance and potential treatment options are shown.
Conclusion:
Scientific insight to the biomolecular mechanisms of cell homeostasis helps to understand and treat all clinically manifestations associated with different stages of chronic fatigue.
Keywords
Chronic idiopathic fatigue; Chronic fatigue syndrome/myalgic encephalopathy; Nrf2, vitamin D3; Metabolic/energetic/redox balance; Cell stress defense mechanisms