A logistic regression analysis of risk factors in ME/CFS pathogenesis. Lacerda et al. 2019

[boolybooly]

Another thing to be careful of is the old association vs causation error.

The association of virus episodes prior to ME onset might be seen as causal, but another way to look at it is that the same unknown etiology might cause both immune failure as an early symptom and ME onset as a later symptom.

At this stage we dont know either way. 2c

 

[Dolphin]

I wonder is anything interesting among these, perhaps particularly from Trudie Chalder?
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1468-2/peer-review

Peer Review reports
From: A logistic regression analysis of risk factors in ME/CFS pathogenesis

Original Submission
14 Aug 2018 Submitted Original manuscript
31 Aug 2018 Reviewed Reviewer Report - Neil R. McGregor
4 Feb 2019 Reviewed Reviewer Report - ANTHONY L KOMAROFF
15 Feb 2019 Reviewed Reviewer Report - Trudie Chalder
8 Apr 2019 Author responded Author comments - Eliana Mattos Lacerda
Resubmission - Version 2
8 Apr 2019 Submitted Manuscript version 2
14 Apr 2019 Reviewed Reviewer Report - ANTHONY L KOMAROFF
28 May 2019 Reviewed Reviewer Report - Research Square
20 Jul 2019 Author responded Author comments - Eliana Mattos Lacerda
Resubmission - Version 3
20 Jul 2019 Submitted Manuscript version 3
19 Aug 2019 Reviewed Reviewer Report - Research Square
9 Sep 2019 Author responded Author comments - Eliana Mattos Lacerda
Resubmission - Version 4
9 Sep 2019 Submitted Manuscript version 4
Publishing
16 Sep 2019 Editorially accepted
7 Nov 2019 Article published 10.1186/s12883-019-1468-2
You can find further information about peer review here.

 

[Dolphin]

I wonder is anything interesting among these, perhaps particularly from Trudie Chalder?
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1468-2/peer-review

I see a statistician was recruited as a reviewer and was paid a “small honorarium”. Might be worthwhile for other journals to do this also.

 

[Dolphin]

I wonder is anything interesting among these, perhaps particularly from Trudie Chalder?
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1468-2/peer-review

A statistical reviewer suggested some other means of analysis (I can’t recall the details now). Prior immunizations in the six months prior to onset dropped out as a risk factor with the new analysis.

One finding could have serious adverse consequences if it is published, and proves to be wrong, highlighting the importance of defining the risk factors accurately. The authors report a significant association of immunizations with the subsequent development of ME/CFS. People who erroneously attribute various ills to immunizations (such as the development of autism) have reduced community immunization rates—with serious health consequences. In the Discussion, the authors carefully cite prior evidence that immunizations are not triggers of ME/CFS. Still, they report the association.

 

[Dolphin]

I wonder is anything interesting among these, perhaps particularly from Trudie Chalder?
https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1468-2/peer-review

With regards to childhood trauma there was one very well conducted study published by Heim et al which showed an association between child hood trauma and CFS. It also highlighted the link to the HPA axis and lower cortisol in those who reported trauma. These papers should be referenced specifically as the study was well conducted.

This study used the Reeves et al (2005) criteria which give a prevalence rate of 2.54% and which are really bad.

 

[Tom Kindlon]

"A logistic regression analysis of risk factors in ME/CFS pathogenesis" (Nov 2019).

Has data on lots of items in table 2 (see image for list) in an unadjusted form of simple numbers & %s in case you're interested in looking at data on your pet theories

https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1468-2