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A genetic polymorphism that is associated with mitochondrial energy metabolism increases risk of fibromyalgia (2020) van Tilburg et al.

Discussion in 'Fibromyalgia and Connective Tissue Disorders' started by Cheshire, Jul 18, 2020.

  1. Cheshire

    Cheshire Moderator Staff Member

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    https://pubmed.ncbi.nlm.nih.gov/32658146/

    No idea if this is a promising lead or not, but here is a thread of one of the PIs explaining what they found
     
    Jaybee00, Trish, Sly Saint and 14 others like this.
  2. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    The prevalence of m.2352T>C is about 1% according to dbSNP
    https://www.ncbi.nlm.nih.gov/snp/rs28358579

    The PI on Twitter responded to a question about prevalence of this variant in FM. A bit hard to interpret, but maybe others figure it out.


    Hopefully the paper will be available on sci-hub at some point.
     
    Last edited: Jul 19, 2020
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  3. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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  4. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    m.2352T>C (rs28358579) has a consequence for gene MT-ND1. This is what Alan Light reported in the 2018 presentation about MT-ND1.

    upload_2020-7-18_21-10-53.png
     
    Last edited: Jul 19, 2020
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  5. rvallee

    rvallee Senior Member (Voting Rights)

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    Weird how this science thing works differently when you follow the evidence where it leads you, instead of grabbing the evidence by the neck and forcing it your way.

     
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  6. strategist

    strategist Senior Member (Voting Rights)

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    She is demonstrating exactly what I believe: that the idea of psychosomatic illness is a false explanation that is preventing the discovery of the real causes of many illnesses. To make progress, these ideas need to be questioned first.
     

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