tryptophan

Changes in blood metabolic profile during repeated cardiopulmonary exercise testing (2xCPET) in ME/CFS patients Henrique Chapola, Katarina Lien,, Sissel Dyrstad, Per Ole Iversen, Karl Johan Tronstad [Line breaks added] ME/CFS is characterized by post-exertional malaise (PEM) and delayed...

Measurement of Genetic Variations in ME/CFS Patients in the IDO2 Gene Encoding an Enzyme Metabolizing Tryptophan Edgar, Christina D.; Blair, Anna; Tate, Warren P. Genetic variations in the indoleamine 2,3-dioxygenase (IDO2) gene that are commonly found in the general population have been...

Persistent immune dysregulation and metabolic alterations following SARS-CoV-2 infection Silvia Lucena Lage; Katherine Bricker-Holt; Joseph M. Rocco; Adam Rupert; Frank X. Donovan; Yevgeniya A. Abramzon; Settara C. Chandrasekharappa; Colton McNinch; Logan Cook; Eduardo Pinheiro Amaral; Gabriel...

Targeted analysis of seven selected tryptophan-melatonin metabolites: Simultaneous quantification of plasma analytes using fast and sensitive UHPLC–MS/MS Kaleta; Kolitha; Novák; Rad; Bergquist; Ubhayasekera Tryptophan-derived metabolites, a group of neurotransmitters essential for various brain...

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...

Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID Lu Yao; Hannah Devotta; Junhui Li; Nonhlanhla Lunjani; Corinna Sadlier; Aonghus Lavelle; Werner C. Albrich; Jens Walter; Paul W. O’Toole; Liam O’Mahony Protection against severe...

Untargeted Metabolomics and Quantitative Analysis of Tryptophan Metabolites in Myalgic Encephalomyelitis Patients and Healthy Volunteers: A Comparative Study Using High-Resolution Mass Spectrometry Sandy Abujrais; Theodosia Vallianatou; Jonas Bergquist Myalgic encephalomyelitis/chronic fatigue...

https://www.diva-portal.org/smash/record.jsf?pid=diva2%3A1890664&dswid=-4864 Exploring the role of tryptophan metabolites in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Development and application of high resolution mass spectrometry methods Abujrais, Sandy 2024...

Fast Targeted Metabolomics for Analyzing Metabolic Diversity of Bacterial Indole Derivatives in ME/CFS Gut Microbiome Huidi Tian; Lei Wang; Elizabeth Aiken; Robert Jervine V. Ortega; Rachel Hardy; Lindsey Placek; Lina Kozhaya; Derya Unutmaz; Julia Oh; Xudong Yao Disruptions in microbial...

There is compelling evidence that a dysregulated immune inflammatory response in neuroinfectious diseases results in modifications in metabolic processes and altered metabolites, directly or indirectly influencing lipid metabolism within the central nervous system (CNS). The challenges in...

Exploring Metabolic Anomalies in COVID-19 and Post-COVID-19: A Machine Learning Approach with Explainable Artificial Intelligence Juan José Oropeza-Valdez; Cristian Padron-Manrique; Aaron Vazquez-Jimenez; Xavier Soberon-Mainero; Osbaldo Resendis-Antonio The COVID-19 pandemic, caused by...

Indole-3-propionic Acid, a Gut Microbiota-Derived Tryptophan Metabolite, Promotes Endothelial Dysfunction Impairing Purinergic-Induced Nitric Oxide Release in Endothelial Cells Geddo, Federica; Antoniotti, Susanna; Gallo, Maria Pia; Querio, Giulia Different gut microbiota-derived metabolites...

Analysis of tryptophan metabolites and related compounds in human and murine tissue: development and validation of a quantitative and semi-quantitative method using high resolution mass spectrometry Sandy Abujrais, ab S. J. Kumari A. Ubhayasekera ab and Jonas Bergquist *ab Abstract...

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants Jeremy P. Gygi; Cole Maguire; Ravi K. Patel; Pramod Shinde; Anna Konstorum; Casey P. Shannon; Leqi Xu; Annmarie Hoch; Naresh Jayavelu; IMPACC...

Critical COVID-19 disease is accompanied by depletion of plasma tryptophan (TRY) and increases in indoleamine-dioxygenase (IDO)-stimulated production of neuroactive tryptophan catabolites (TRYCATs), including kynurenine (KYN). The TRYCAT pathway has not been studied extensively in association...

Abstract The causes of depression are diverse and are still not fully understood. Recently, an increasing role is attributed to nutritional and inflammatory factors. The aim of this study was to evaluate selected metabolites of the tryptophan kynurenine pathway in depressive patients with small...

I present here a comparison between the levels of tryptophan (Trp), kynurenine (Kyn), serotonin (Ser), Kyn/Trp, and Ser/Trp in cerebrospinal fluid of 44 ME/CFS patients vs 21 sedentary controls. Raw data were retrieved from (Baraniuk JN et al. 2021). Stratification by sex has been included in...

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and highly debilitating long-term illness. People with ME/CFS are typically unable to carry out their routine activities. Key hallmarks of the disease are neurological and gastrointestinal impairments...

Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells, and microbiota Yunke Li, Ning Liu, Yao Ge, Ying Yang, Fazheng Ren, Zhenlong Wu Abstract The intestinal mucosal barrier is critical for the absorption of nutrients and the health of both...

Background: The gut microbiome has been linked to the onset of cardiometabolic diseases, in part facilitated through gut microbiota-dependent metabolites such as trimethylamine-N-oxide. However, molecular pathways associated to heart failure mediated by microbial metabolites remain largely...