thrombosis

Long COVID and Reduced Thrombosis in Antihistamine Treated Patients: An Observational Study in the Metropolitan Area of Barcelona BACKGROUND Early evidence from a nursing home in Yepes (Toledo, Spain) indicated that antihistamines combined with azithromycin prevented deaths and...

Abstract Background Cerebral venous sinus thrombosis (CVST) is a rare diagnosis and is estimated at 1.32-1.57 per 100,000 cases. Patients with CVST often present with headache, seizures, focal motor deficits, encephalopathy, or aphasia, and can be fatal in 3%-15% of cases. Newer diagnostic...

Abstract: The hemostatic system prevents and stops bleeding, maintaining circulatory integrity after injury. It directly interacts with the complement system, which is key to innate immunity. In coronavirus disease 2019 (COVID-19), dysregulation of the hemostatic and complement systems has been...

Abstract Although the connection between COVID-19 and coagulopathy has been clear since the early days of SARS-CoV-2 pandemic, the underlying molecular mechanisms remain unclear. Available data support that the burst of cytokines and bradykinin, observed in some COVID-19 patients, sustains...

Thrombotic Consequences of COVID-19 Infection on Microsurgical Reconstruction Sabrina H. Han; Kyle Ockerman; Matthew Kirchmier; Markos Mardourian; Jaimie Bryan; Elizabeth Cox; Harvey Chim; Lisa Spiguel; Arash Momeni; Sarah Sorice-Virk BACKGROUND Evidence has shown increased morbidity and...

Link to post with the abstract of the final published paper here Preprint Dysregulated Platelet Function in Patients with Post-Acute Sequelae of COVID-19 Anu Aggarwal; Tamanna K. Singh; Michael Pham; Matthew Godwin; Rui Chen; Thomas M. McIntyre; Alliefair Scalise; Mina K. Chung; Courtney...

A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk Verdier, Hippolyte; Thomas, Patrick; Batista, Joana; Kempster, Carly; McKinney, Harriet; Gleadall, Nicholas; Danesh, John; Mumford, Andrew; Heemskerk, Johan W. M.; Ouwehand, Willem H...

Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19 Nair, Soumyalekshmi; Nova-Lamperti, Estefania; Labarca, Gonzalo; Kulasinghe, Arutha; Short, Kirsty R.; Carrión, Flavio; Salomon, Carlos COVID-19 continues to affect an unprecedented number...

Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis Asim Cengiz Akbulut; Ryanne A. Arisz; Constance C. F. M. J. Baaten; Gaukhar Baidildinova; Aarazo Barakzie; Rupert Bauersachs; Jur ten Berg; Wout W. A. van den Broek; H. C. de Boer; Amandine...

Monitoring circulating platelet activity to predict cancer-associated thrombosis Li; Lu; Yang; Zhang; Wang; Chu; Wang; Qi; Anderson; Jiang; Song; Nie; Li A characteristic clinical complication in cancer patients is the frequent incidence of thrombotic events. Numerous studies have shown...

Plasma from patients with pulmonary embolism show aggregates that reduce after anticoagulation Baker, Stephen R.; Halliday, Georgia; Ząbczyk, Michal; Alkarithi, Ghadir; Macrae, Fraser L.; Undas, Anetta; Hunt, Beverley J.; Ariëns, Robert A. S. Background Microclots, a term also used for amyloid...

SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling Perico, Luca; Morigi, Marina; Pezzotta, Anna; Locatelli, Monica; Imberti, Barbara; Corna, Daniela; Cerullo, Domenico; Benigni, Ariela; Remuzzi, Giuseppe The...

Prophylactic rivaroxaban in the early post-discharge period reduces the rates of hospitalization for atrial fibrillation and incidence of sudden cardiac death during long-term follow-up in hospitalized COVID-19 survivors Fiedler, Lukas; Motloch, Lukas J.; Dieplinger, Anna-Maria; Jirak, Peter...

Pulmonary circulation abnormalities in post-acute COVID-19 syndrome: dual-energy CT angiographic findings in 79 patients Mohamed, Islam; de Broucker, Virginie; Duhamel, Alain; Giordano, Jessica; Ego, Alice; Fonne, Nicolas; Chenivesse, Cécile; Remy, Jacques; Remy-Jardin, Martine Objectives To...

Analysis of thrombogenicity under flow reveals new insights into the prothrombotic state of patients with post-COVID syndrome Adela Constantinescu-Bercu, Anna Kessler, Rens de Groot, Bertina Dragunaite, Melissa Heightman, Toby Hillman, Laura C. Price, Ewan Brennan, Raphael Sivera, Karen...

SARS-CoV-2 Spike protein promotes vWF secretion and thrombosis via endothelial cytoskeleton-associated protein 4 (CKAP4) Kan Li, Liu Yao, Jin Wang, Hao Song, Yan-hong Zhang, Xue Bai, Kai Zhang, Dong-ming Zhou, Ding Ai, Yi Zhu Letter to Nature: Signal Transduction and Targeted Therapy Link | PDF

COVID-19 patient fibrinogen produces dense clots with altered polymerization kinetics, partially explained by increased sialic acid Moiseiwitsch N, Zwennes N, Szlam F, Sniecinski R, Brown A Background: Thrombogenicity is a known complication of COVID-19, resulting from SARS-Cov-2 infection...

Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales Knight R, Walker V, Ip S, Cooper JA, Bolton T, Keene S, Denholm R, Akbari A, Abbasizanjani H, Torabi F, Omigie E, Hollings S, North TL, Toms R...

Abstract The pathophysiology of COVID-19-associated coagulopathy is complex and not fully understood. SARS-CoV-2 spike protein (SP) may activate platelets and interact with fibrin(ogen). We aimed to investigate whether isolated SP can be present in clots retrieved in COVID-19 patients with...

Early antithrombotic post-discharge therapy using prophylactic DOAC or dipyridamole improves long-term survival and cardiovascular outcomes in hospitalized COVID-19 survivors Motloch LJ, Jirak P, Mirna M, Fiedler L, Davtyan PA, Lakman IA, Gareeva DF, Tyurin AV, Gumerov RM, Matskeplishvili ST...