Monitoring circulating platelet activity to predict cancer-associated thrombosis, 2023, Li et al.

Discussion in 'Other health news and research' started by SNT Gatchaman, Aug 5, 2023.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights) Staff Member

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    Monitoring circulating platelet activity to predict cancer-associated thrombosis
    Li; Lu; Yang; Zhang; Wang; Chu; Wang; Qi; Anderson; Jiang; Song; Nie; Li

    A characteristic clinical complication in cancer patients is the frequent incidence of thrombotic events. Numerous studies have shown hyperactive/activated platelets to be a critical earlier trigger for cancer-asso- ciated thrombus formation. However, there currently is no viable approach to monitor specific changes in tumor-associated platelet activity.

    Here, we describe a chromatograph-like microfluidic device that is highly sensitive to the activity status of peripheral circulating platelets in both tumor-bearing mice and clinical can- cer patients. Our results show a strongly positive correlation between platelet activation status and tumor progression. Six-month follow-up data from advanced cancer patients reveal positive links between platelet activity level and thrombus occurrence rate, with a high predictive capacity of thrombotic events (AUC = 0.842).

    Our findings suggest that circulating platelet activity status determined by this microfluidic device exhibits sensitive, predictive potential for thrombotic events in cancer patients for directing well-timed antith- rombosis treatment.

    Link | PDF (Cell Reports Methods)
     
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