Review Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis, 2023, Akbulut et al.

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  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis
    Asim Cengiz Akbulut; Ryanne A. Arisz; Constance C. F. M. J. Baaten; Gaukhar Baidildinova; Aarazo Barakzie; Rupert Bauersachs; Jur ten Berg; Wout W. A. van den Broek; H. C. de Boer; Amandine Bonifay; Vanessa Bröker; Richard J. Buka; Hugo ten Cate; Arina J. ten Cate-Hoek; S. Cointe; Ciro De Luca; Ilaria De Simone; Rocio Vacik Diaz; Françoise Dignat-George; Kathleen Freson; Giulia Gazzaniga; Eric C. M. van Gorp; Anxhela Habibi; Yvonne M. C. Henskens; Aaron F. J. Iding; Abdullah Khan; Gijsje H. Koenderink; Akhil Konkoth; Romaric Lacroix; Trisha Lahiri; Wilbur Lam; Rachel E. Lamerton; Roberto Lorusso; Qi Luo; Coen Maas; Owen J. T. McCarty; Paola E. J. van der Meijden; Joost C. M. Meijers; Adarsh K. Mohapatra; Neta Nevo; Alejandro Pallares Robles; Philippe Poncelet; Christoph Reinhardt; Wolfram Ruf; Ronald Saraswat; Claudia Schönichen; Roger Schutgens; Paolo Simioni; Stefano Spada; Henri M. H. Spronk; Karlygash Tazhibayeva; Jecko Thachil; Rocio Vacik Diaz; L. Vallier; Alicia Veninga; Peter Verhamme; Chantal Visser; Steve P. Watson; Philip Wenzel; Ruth A. L. Willems; Anne Willers; Pengyu Zhang; Konstantinos Zifkos; Anton Jan van Zonneveld

    The Fourth Maastricht Consensus Conference on Thrombosis included the following themes.

    Theme 1: The “coagulome” as a critical driver of cardiovascular disease. Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow, and kidney. Four investigators shared their views on these organ-specific topics.

    Theme 2: Novel mechanisms of thrombosis. Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infection-associated coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding.

    Theme 3: How to limit bleeding risks: insights from translational studies. This theme included state-of-the-art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed.

    Theme 4: Hemostasis in extracorporeal systems: the value and limitations of ex vivo models. Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularized organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation-associated coagulopathy are discussed.

    Theme 5: Clinical dilemmas in thrombosis and antithrombotic management. Plenary presentations addressed controversial areas, i.e., thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies, and clinically tested factor XI(a) inhibitors, both possibly with reduced bleeding risk.

    Finally, COVID-19-associated coagulopathy is revisited.

    Link | PDF (Thrombosis and Haemostasis)
     
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  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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