proteomics

Proteomic profiling of serum small extracellular vesicles predicts post-COVID syndrome development Dobra; Gyukity-Sebestyen; Bukva; Boroczky; Nyiraty; Bordacs; Varkonyi; Kocsis; Szabo; Kecskemeti; Polgar; Szell; Buzas Post-COVID syndrome affects 10–35 % of COVID-19 patients, and up to 85 % of...

Abstract: Background. Long COVID involves persistent symptoms after COVID-19 recovery, affecting multiple organ systems for months or years. Risk factors include female sex, prior chronic conditions, severe SARS-CoV-2 infection, reinfections, and lack of vaccination. As a major public health...

Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had COVID-19 Jiangfeng Liu; Li Guo; Jingchuan Zhong; Yue Wu; Xinming Wang; Xiaoyue Tang; Kaiyuan Min; Yehong Yang; Wanjun Peng; Qiaochu Wang; Tao Ding; Xiaoying...

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...

Abstract: Long COVID represents a significant global health challenge with an unclear etiology. Alongside accumulating evidence of mitochondrial dysfunction in patients with acute SARS-CoV-2 infection, a symptomatic overlap exists between long COVID and mitochondrial disorders. However, the...

Proteomics Reveals That Vitamin D Deficiency Leads to Immunoglobulin Abnormalities and Immune Dysregulation in Patients with Post-COVID-19 Condition Wenrui Ji; Xiaomin Xie; Guirong Bai; Yalei Fan; Yanting He; Li Zhang; Haiyan Zhou; Ling Li; Huan Li Vitamin D (VD) levels are closely related to...

Background Recent proteomic studies have documented that Long COVID in adults is characterized by a pro-inflammatory signature with thromboinflammation. However, if similar events happen also in children with Long COVID has never been investigated. Methods We performed an extensive protein...

Now published - link to post Preprint Quantitative serum proteomic analysis for biomarker discovery in post-COVID-19 Postural Orthostatic Tachycardia Syndrome PC-POTS patients Taekyung Ryu; Brit Adler; Seeun Judy Jeong; David C. Lee; Tae Hwan Chung Postural orthostatic tachycardia syndrome...

Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19 Yulin Wei, Hongyan Gu, Jun Ma, Xiaojuan Mao, Bing Wang, Weiyan Wu, Shimin Yu, Jinyuan Wang, Huan Zhao, yanbin he [Preprint] Abstract Long COVID is an often-debilitating condition with...

Proteomic analysis of post-COVID condition: Insights from plasma and pellet blood fractions Alejandro Seco-González, Paula Antelo-Riveiro, Susana B. Bravo, P.F. Garrido, M.J. Domínguez-Santalla, E. Rodríguez-Ruiz, Á. Piñeiro, R. Garcia-Fandino Background Persistent symptoms extending beyond...

Plasma proteome demonstrates sex-specific associations with mental health risks in adolescents Alexey Afonin, Aino-Kaisa Piironen, Jordi Julvez, Irene van Kamp, Katja M Kanninen [Pre-print] Abstract Adolescence is a critical developmental period marked by significant physiological...

Link: https://www.cell.com/cell/fulltext/S0092-8674(24)01268-6 Highlights • Construct a comprehensive proteomics atlas for 1,706 human diseases and traits • Machine-learning-based big data uncover promising diagnostic and predictive biomarkers • Identify 37 drug repurposing prospects and 26...

Alterations in the plasma proteome persist ten months after recovery from mild to moderate SARS-CoV-2 infection Huapaya, Julio A.; Gairhe, Salina; Kanth, Shreya; Tian, Xin; Demirkale, Cumhur Y.; Regenold, David; Sun, Jian; Lynch, Nicolas F.; Luo, Renjie; Forsberg, Alisa; Dewar, Robin; Rehman...

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations Argentieri, M. Austin; Xiao, Sihao; Bennett, Derrick; Winchester, Laura; Nevado-Holgado, Alejo J.; Ghose, Upamanyu; Albukhari, Ashwag; Yao, Pang; Mazidi, Mohsen; Lv, Jun; Millwood, Iona; Fry...

Molecular overlaps of neurological manifestations of COVID-19 and schizophrenia from a proteomic perspective Antunes, André S. L. M.; Reis-de-Oliveira, Guilherme; Martins-de-Souza, Daniel COVID-19, a complex multisystem disorder affecting the central nervous system, can also have psychiatric...

Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset Jenny Hällqvist, Michael Bartl, Mohammed Dakna, Sebastian Schade, Paolo Garagnani, Maria-Giulia Bacalini, Chiara Pirazzini, Kailash Bhatia, Sebastian Schreglmann, Mary Xylaki, Sandrina Weber...

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST Hans-Georg Sprenger; Melanie J. Mittenbühler; Yizhi Sun; Jonathan G. Van Vranken; Sebastian Schindler; Abhilash Jayaraj; Sumeet A. Khetarpal; Ariana Vargas-Castillo; Anna M. Puszynska; Jessica...

Targeting the High-Density Lipoprotein Proteome for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Grote, Karsten; Schaefer, Ann-Christin; Soufi, Muhidien; Ruppert, Volker; Linne, Uwe; Mukund Bhagwat, Aditya; Szymanski, Witold; Graumann, Johannes; Gercke, Yana; Aldudak, Sümeya...

Quantitative Proteomics of COVID-19 Recovered Patients Identifies Long-Term Changes in Sperm Proteins Leading to Cellular Stress in Spermatozoa Chopra, Parul; Tomar, Anil Kumar; Thapliyal, Ayushi; Ranjan, Piyush; Datta, Sudip Kumar; Yadav, Savita Following an initial recovery, COVID-19...

Role of the complement system in Long COVID Vadim Farztdinov; Boris Zuehlke; Franziska Sotzny; Fridolin Steinbeis; Martina Seifert; Claudia Kedor; Kirsten Wittke; Pinkus Tober-Lau; Kathrin Textoris-Taube; Daniela Ludwig; Clemens Dierks; Dominik Bierbaum; Leif Erik Sander; Leif Gunnar Hanitsch...