platelets

Immunothrombosis in hospitalized COVID-19 patients identified by multiomics profiling and linked to postacute complications Post-acute sequelae of COVID-19 (PASC) disproportionately affect hospitalized patients and require improved molecular characterization to inform patient management...

An imaging flow cytometry method to study platelet-monocyte aggregates using Long COVID as a model Background Long COVID is characterised by persistent systemic inflammation and endothelial dysfunction, with increasing evidence implicating thromboinflammatory mechanisms. Platelet-monocyte...

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients Abstract Chronic persistence of systemic symptoms after recovery from active CoVID-19 has become a significant disease burden, named post-CoVID syndrome...

Platelet defects in patients and mice with Ehlers-Danlos syndrome Ehlers-Danlos syndrome (EDS) is a group of connective tissue disorders characterized by joint hypermobility, skin hyperelasticity, perivascular tissue fragility, easy bruising, and increased bleeding risk. Abnormal bleeding in...

Adenoviral Inciting Antigen and Somatic Hypermutation in VITT BACKGROUND Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a rare prothrombotic complication that occurs after adenoviral vector–based vaccination against coronavirus disease 2019; in rare cases, it can also occur...

Full title: Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9–associated depletion of gamma delta and mucosal-associated invariant T cells in Long COVID with ME/CFS The cellular mechanisms underlying Long COVID (LC) associated with myalgic...

Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19 Immunometabolism and neutrophil extracellular traps (NETs) play pivotal roles in the pathogenesis of coronavirus disease 2019 (COVID-19) and its postacute sequelae. However, the...

Blood pro-thrombotic analytes and platelet activation are associated with post-acute sequelae of COVID-19 Post-Acute Sequelae of COVID-19 (PASC), or “long COVID,” describes persistent symptoms following recovery from SARS-CoV-2 infection. Early identification of circulating biomarkers...

A Comparative Study of the Coagulation Systems and Inflammatory Profiles of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Patients with Long COVID Hayley Emma Arron Supervisor: Prof. Etheresia Pretorius Stellenbosch University [Line breaks added] Abstract Myalgic...

Regulation of m7G methylation in long COVID: Expression profiles and early predictive value of key genes Bai, Wenmei; Li, Fengsen Long COVID (LC) poses ongoing public health challenges due to its persistent symptoms following severe acute respiratory syndrome coronavirus 2 infection. Early...

Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome Anne E. Gardella, Daniel Eweis-LaBolle, Conor J. Loy, Emma D. Belcher, Joan S. Lenz, Carl J. Franconi, Sally Y. Scofield, Andrew Grimson, Maureen R. Hanson, Iwijn De...

A novel metacyte metafer classifier for platelet morphology using long COVID as a model Chantelle Venter, Jan H. Pretorius, Douglas B. Kell, Etheresia Pretorius [Line breaks added] Abstract Platelets play a critical role in coagulation and are implicated in pathological clotting. This study...

Fatemeh Arastehnazar, Mohammad Hessam Rafiee, Mohammad Reza Deyhim, Faezeh Ghasemi, Amir Teimourpour Funding: This work was supported by Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine Iran ABSTRACT Background COVID-19 can affect...

Estimating Long COVID-19 prevalence across definitions and forms of sample selection Pietro Giorgio Lovaglio, Fabio Borgonovo, Alessandro Manzo Margiotta, Mohamed Mowafy, Marta Colaneri, Alessandra Bandera, Andrea Gori, Amedeo Ferdinando Capetti [Line breaks added] Abstract Long COVID (LC) is...

A simple platelet biomarker is associated with symptom severity in major depressive disorder Aksu Gunay, Steven D. Targum, Alex D. Leow, Olusola Ajilore & Mark M. Rasenick [Line breaks added] Abstract Previous studies have shown that the heterotrimeric G protein, Gsalpha (Gsα), is ensconced...

SARS-CoV-2 S1 protein induces IgG-mediated platelet activation and is prevented by 1.8-cineole Petry; Shoykhet; Weiser; Griesbaum; Bashiri Dezfouli; Verschoor; Wollenberg COVID-19 patients face an increased risk of thromboembolic complications, yet the exact pathophysiological role of platelets...

Now published - link to post Preprint Quantitative serum proteomic analysis for biomarker discovery in post-COVID-19 Postural Orthostatic Tachycardia Syndrome PC-POTS patients Taekyung Ryu; Brit Adler; Seeun Judy Jeong; David C. Lee; Tae Hwan Chung Postural orthostatic tachycardia syndrome...

Hypercoagulable Rotational Thromboelastometry During Hospital Stay Is Associated with Post-Discharge DLco Impairment in Patients with COVID-19-Related Pneumonia Loutsidi, Natasa-Eleni; Politou, Marianna; Vlahakos, Vassilios; Korakakis, Dimitrios; Kassi, Theodora; Nika, Asimina; Pouliakis...

Proteomic and metabolomic profiling of plasma uncovers immune responses in patients with Long COVID-19 Yulin Wei, Hongyan Gu, Jun Ma, Xiaojuan Mao, Bing Wang, Weiyan Wu, Shimin Yu, Jinyuan Wang, Huan Zhao, yanbin he [Preprint] Abstract Long COVID is an often-debilitating condition with...

Platelets as key cells in endometriosis patients: Insights from small extracellular vesicles in peritoneal fluid and endometriotic lesions analysis Barbara Bortot; Roberta Di Florio; Simona Merighi; Ben Peacock; Rebecca Lees; Francesco Valle; Marco Brucale; Alessandro Mangogna; Giovanni Di...