pain

Nurse Implementation of Music for Pain Relief in the Inpatient Setting Abstract Background The music for pain relief study tested an innovative broad hypothesis that nurses can effectively integrate the use of music as an option for pain and anxiety management among their patients. The...

An Embodied Predictive Processing Theory of Pain Experience Kiverstein, Julian; Kirchhoff, Michael D.; Thacker, Mick Abstract This paper aims to provide a theoretical framework for explaining the subjective character of pain experience in terms of what we will call ‘embodied predictive...

Individualized Algorithm-Based Intermittent Hypoxia Improves Quality of Life in Patients Suffering from Long-Term Sequelae After COVID-19 Infection Abstract Background/Objectives: Post-COVID-19 condition (PCC), also known as long COVID, has emerged as a recognized syndrome affecting millions...

Lysophospholipid–TRPV1 interactions in chemotherapy-induced neuropathy Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of first-line chemotherapeutics such as paclitaxel, for which effective treatments are currently unavailable. We found that plasma...

Functional dissociation of stimulus intensity encoding and predictive coding of pain in the insula Abstract The computational principles by which the brain creates a painful experience from nociception are still unknown. Classic theories suggest that cortical regions either reflect stimulus...

Modality-specific neurovascular coupling via layer-segregated arteriole networks INTRODUCTION The brain continuously adjusts blood flow in response to elevations in neuronal activity through a process known as neurovascular coupling. These vascular responses form the basis of widely used brain...

Dorsal horn DCC amplification loop induced by endplate osteoclasts generates chronic nociplastic low back pain in male mice Spine degeneration is associated with low back pain (LBP), a major cause of disability and functional decline. However, effective therapies for non-specific LBP remain...

Immunopharmacological mechanisms underlying SARS-CoV-2 spike-induced persistent pain in mice SARS-CoV-2 infection is frequently associated with persistent pain, yet the underlying mechanisms remain poorly understood. Given that viral structural proteins can act as pathogen-associated molecular...

Macrophage-derived netrin-1 contributes to endometriosis-associated pain BACKGROUND Endometriosis-associated pain can be considered a type of neuropathic pain. Netrin-1 is an axon guidance cue that regulates axonal attraction or rejection in neural injury and regeneration. However, whether...

Molecular architecture of human dermal sleeping nociceptors Human dermal sleeping nociceptors display ongoing activity in neuropathic pain, affecting 10% of the population. Despite advances in rodents, a molecular marker for these mechano-insensitive C-fibers (CMis) in human skin remains...

Excessive epithelial mechanosensation drives nociceptive innervation and chronic bladder pain via the PIEZO1-SLC7A11-glutamate axis Epithelial mechanosensation maintains tissue homeostasis by sensing mechanical stimuli. Dysregulated mechanotransduction has been implicated in chronic pain, yet...

Patterns of Muscle Health in Single- and Multi-Site Chronic Pain: A UK Biobank Normative Modeling Study BACKGROUND Chronic pain is associated with impaired muscle health, but whether these changes reflect site-specific factors, broader systemic factors, or both remains unclear. The purpose of...

Pain Neuroscience Education als Intervention zur Verbesserung der Lebensqualität bei Patienten mit chronischen Kreuzschmerzen Irle, Lisa; Alfuth, Martin Abstract Background Educational strategies that improve understanding of pain can influence the behaviour of patients with chronic low back...

Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach Abstract Abstract Chronic neuropathic pain is a debilitating neuroplastic disorder that notably impacts the quality of life of millions of people worldwide. This complex condition...

Education about pain and experience with cognitive-based interventions do not reduce healthcare professionals’ chronic pain Weisman, Asaf; Yona, Tomer; Masharawi, Youssef Background Cognitive-based interventions like pain neuroscience education (PNE), cognitive behavioral therapy (CBT)...

Adieu to an aphorism: why nociception is necessary for pain Weisman, Asaf; Quintner, John; Cohen, Milton Abstract An aphorism is a short saying intended to express a general truth. In this article, the popular aphorism, 'nociception is neither necessary nor sufficient for pain', is critically...

Psychophysiologic symptom relief therapy for chronic back pain: a pilot randomized controlled trial Introduction: Chronic back pain is the leading cause of disability in the United States. Based on the hypothesis that nonspecific back pain may be rooted in a psychophysiologic etiology, we...

Abstract Allodynia (perceiving touch as painful) is an enduring symptom of neuropathic pain. While acute pain is initiated by afferent signaling from the periphery to spinal cord, pain chronification recruits ongoing activity in supraspinal sites. One such site that has been proposed to be...

Now published, see post #4. Perioperative outcomes in myalgic encephalomyelitis/chronic fatigue syndrome undergoing general anesthesia: a retrospective matched-pair study BACKGROUND Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic multisystem disease characterized by...

Until a few days ago, I did not know this award existed. I found this description of the co-winners of the prize. work to be interesting and a worthwhile read. This is one area where mouse models have contributed towards advancing the understanding of the human physiology. The complexity of...