mitochondrial dysfunction

  1. SNT Gatchaman

    Preprint The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction., 2025, Koenig et al.

    The Role of SARS-CoV-2 Nucleocapsid Protein Persistence in Inducing Chronic Type I Interferon and Mitochondrial Dysfunction. Andreas Koenig; Mohammad Quasem; Benjamin Zink; Doniyorbek Abdulla-Zoda; Priyanka Karunanidhi; Karolina Sienko; Christian Geier; Venkatesh Jayaraman; Rabia Malik; Kanza...
    • SNT Gatchaman
    • Thread
    • autoimmunity inteferon mavs mitochochria mitochondrial dysfunction systemic lupus erythematosus viral persistence
    • Replies: 0
    • Forum: Long Covid research
  2. forestglip

    [Transcriptome] in PBMCs of [LC] at a median follow-up of 28 months [...] reveals upregulation of JAK/STAT [...], 2025, Fineschi et al

    Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...
    • forestglip
    • Thread
    • atp ifn il-9 jak-stat long covid mitochochria mitochondrial dysfunction oxidative phosphorylation ubiquitination
    • Replies: 18
    • Forum: Long Covid research
  3. forestglip

    mtDNA deletion [...] with < 10 % heteroplasmy in muscle and isolated complex-V dysfunction misinterpreted as [CFS] over 21-years, 2025, Finsterer+

    mtDNA deletion m.8753_16566 with < 10 % heteroplasmy in muscle and isolated complex-V dysfunction misinterpreted as chronic fatigue syndrome over 21-years Josef Finsterer, Ana C. Fiorini, Fulvio A. Scorza, Carla A. Scorza [No abstract] Link | PDF (Clinics) [Open Access]
    • forestglip
    • Thread
    • complex v me/cfs mitochondrial dna mitochondrial dysfunction
    • Replies: 12
    • Forum: ME/CFS research
  4. Wyva

    Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related (...), 2025, Fekete et al

    Full title: Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 Rebeka Fekete, Alba Simats, Eduárd Bíró, Balázs Pósfai, Csaba Cserép, Anett D. Schwarcz, Eszter Szabadits, Zsuzsanna Környei, Krisztina...
    • Wyva
    • Thread
    • aquaporin autonomic nervous system autopsy brain gliovascular failure inflammation interleukin 1 interleukin 6 microglia mitochondrial dysfunction myelin neuroimmune
    • Replies: 1
    • Forum: Long Covid research
  5. Nightsong

    Genetic Landscape and Mitochondrial Metabolic Dysregulation in Patients Suffering From Severe Long COVID, 2025, Hansen et al

    Abstract: Long COVID represents a significant global health challenge with an unclear etiology. Alongside accumulating evidence of mitochondrial dysfunction in patients with acute SARS-CoV-2 infection, a symptomatic overlap exists between long COVID and mitochondrial disorders. However, the...
    • Nightsong
    • Thread
    • bioenergetics genetic long covid mitochondrial dysfunction pbmc proteomics wes wgs whole genome sequencing
    • Replies: 2
    • Forum: Long Covid research
  6. SNT Gatchaman

    Review Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Syed, Karius, Wang, Hwang

    Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abu Mohammad Syed; Alexander K. Karius; Jin Ma; Ping-yuan Wang; Paul M. Hwang ME/CFS is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms...
    • SNT Gatchaman
    • Thread
    • actin atp eif2a endoplasmic reticulum er stress interferon jak-stat mitochochria mitochondrial dysfunction nf-κb wasf3
    • Replies: 15
    • Forum: ME/CFS research
  7. SNT Gatchaman

    Review A Comprehensive Review of the Contribution of Mitochondrial DNA Mutations and Dysfunction in Polycystic Ovary Syndrome, 2025, Kobayashi+

    A Comprehensive Review of the Contribution of Mitochondrial DNA Mutations and Dysfunction in Polycystic Ovary Syndrome, Supported by Secondary Database Analysis Kobayashi, Hiroshi; Matsubara, Sho; Yoshimoto, Chiharu; Shigetomi, Hiroshi; Imanaka, Shogo Polycystic ovary syndrome (PCOS) is a...
  8. forestglip

    1H and 31P MR Spectroscopy to Assess Muscle Mitochondrial Dysfunction in Long COVID, 2024, Finnigan et al

    1H and 31P MR Spectroscopy to Assess Muscle Mitochondrial Dysfunction in Long COVID Lucy E. M. Finnigan, Mark Philip Cassar, Mehrsa Jafarpour, Antonella Sultana, Zakariye Ashkir, Karim Azer, Stefan Neubauer, Damian J. Tyler, Betty Raman, Ladislav Valkovič Background Emerging evidence suggests...
    • forestglip
    • Thread
    • carnosine chalder fatigue questionnaire long covid mitochondria mitochondrial capacity mitochondrial dysfunction phosphocreatine qmax tpcr
    • Replies: 6
    • Forum: Long Covid research
  9. pooriepoor91

    Preprint Mitochondrial Gene Signatures Illuminate Mitochondrial Function as an Important Contributor to Post-COVID Recovery and Long COVID Progression, 2024,..

    https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4950019 Authors: Ana R. Silverstein, Junxiang Wan, Kelvin Yen, Hemal H. Mehta, Hiroshi Kumagai, Melanie Flores, Jesse Goodrich, Howard Hu, Jeffrey D. Klausner, Omid Akbari, Igor Koralnik, Pinchas Cohen Abstract Long COVID, affecting an...
    • pooriepoor91
    • Thread
    • long covid pathology mitochondrial dysfunction mitochondrial repair post covid recovery post-acute sequelae of covid-19
    • Replies: 4
    • Forum: Long Covid research
  10. Mij

    Soluble IL-2R impairs muscle cell mitochondrial respiration in fatigued individuals with post-acute sequelae of COVID-19, 2024, Peterson Brown

    Abstract Post-acute sequelae of COVID (PASC) persist in many patients for weeks and months after recovery from initial SARS-CoV-2 infection. Recent evidence suggests that pathological changes in skeletal muscle may contribute significantly to ongoing pain and fatigue, particularly...
    • Mij
    • Thread
    • cd25 il-2 il-2r jak-stat mitochondrial dysfunction muscle biopsy oxygen use seahorse t-cells
    • Replies: 10
    • Forum: Long Covid research
  11. SNT Gatchaman

    Review Long COVID science, research and policy, 2024, Al-Aly, Davis, McCorkell, Iwasaki, Topol+

    Long COVID science, research and policy Al-Aly, Ziyad; Davis, Hannah; McCorkell, Lisa; Soares, Letícia; Wulf-Hanson, Sarah; Iwasaki, Akiko; Topol, Eric J. Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex...
    • SNT Gatchaman
    • Thread
    • complement economic impact endothelial dysfunction immune dysregulation mitochondrial dysfunction viral persistence
    • Replies: 17
    • Forum: Long Covid research
  12. forestglip

    [Myalgic encephalomyelitis : etiopathogenesis, diagnosis and treatment], 2024, Scherrer et al

    [Myalgic encephalomyelitis : etiopathogenesis, diagnosis and treatment] (Full article in French) Robin Scherrer, Marian Galovic, Markus Gschwind, Octavia Sabin Published 17 July 2024 Abstract Myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome (CFS), is a neurological...
    • forestglip
    • Thread
    • immunological inflammation me/cfs mitochondrial dysfunction oxidative stress switzerland
    • Replies: 3
    • Forum: ME/CFS research
  13. SNT Gatchaman

    Altered mitochondrial respiration in peripheral blood mononuclear cells of post-acute sequelae of SARS-CoV-2 infection, 2024, Dirajlal-Fargo et al.

    Altered mitochondrial respiration in peripheral blood mononuclear cells of post-acute sequelae of SARS-CoV-2 infection Dirajlal-Fargo; Maison; Durieux; Andrukhiv; Funderburg; Ailstock; Gerschenson; Mccomsey Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured ex vivo...
  14. SNT Gatchaman

    Preprint Systemic Genome Correlation Loss as a Central Characteristic of Spaceflight, 2024, Sakharkar et al.

    Systemic Genome Correlation Loss as a Central Characteristic of Spaceflight Anurag Sakharkar; Kiven Erique Lukong; Lauren M Sanders; Sylvain V Costes; Jian Yang; Changiz Taghibiglou Space exploration has captured the imagination of humanity for generations. From the first steps on the moon to...
    • SNT Gatchaman
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    • collagen corticotropin epigenetics genes metabolomics mirna mitochondria mitochondrial dysfunction proteomics spaceflight transcriptomics vegf
    • Replies: 2
    • Forum: Other health news and research
  15. SNT Gatchaman

    Review Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview, 2024, Mantle et al.

    Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview Mantle, David; Hargreaves, Iain Parry; Domingo, Joan Carles; Castro-Marrero, Jesus Post-viral fatigue syndrome (PVFS) encompasses a wide range of complex neuroimmune disorders of unknown...
  16. rvallee

    Differential Cardiopulmonary Hemodynamic Phenotypes in PASC Related Exercise Intolerance, 2023, Singh et al

    Differential Cardiopulmonary Hemodynamic Phenotypes in PASC Related Exercise Intolerance https://openres.ersjournals.com/content/early/2023/12/07/23120541.00714-2023 Background Post-acute sequelae of COVID-19 (PASC) affects a significant portion of patients who have previously contracted...
    • rvallee
    • Thread
    • cpet exertion intolerance icpet long covid mitochondrial dysfunction muscle oxygen extraction
    • Replies: 8
    • Forum: Long Covid research
  17. SNT Gatchaman

    Maximal oxidative capacity during exercise is associated with muscle power output in patients with [long Covid], 2023, Ramírez-Vélez et al.

    Maximal oxidative capacity during exercise is associated with muscle power output in patients with long coronavirus disease 2019 COVID-19 syndrome. A moderation analysis Robinson Ramírez-Vélez; Sergio Oscoz-Ochandorena; Yesenia García-Alonso; Nora García-Alonso; Gaizka Legarra-Gorgoñon; Julio...
    • SNT Gatchaman
    • Thread
    • cpet fat oxidation long covid mitochondria mitochondrial dysfunction muscle muscle weakness oxygen extraction
    • Replies: 1
    • Forum: Long Covid research
  18. SNT Gatchaman

    Reduced athletic performance post-COVID-19 is associated with reduced anaerobic threshold, 2023, Barker-Davies et al.

    Reduced athletic performance post-COVID-19 is associated with reduced anaerobic threshold Robert M Barker-Davies; Peter Ladlow; Rebecca Chamley; Edward Nicol; David A Holdsworth Detailed characterisation of cardiopulmonary limitations in patients post-COVID-19 is currently limited, particularly...
    • SNT Gatchaman
    • Thread
    • aerobic respiration athlete covid cpet fat oxidation long covid mitochondria mitochondrial dysfunction oxidative phosphorylation oxphos vo2max
    • Replies: 3
    • Forum: Long Covid research
  19. rvallee

    Mitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity, 2023, Patel et al

    Mitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity https://www.nature.com/articles/s41598-023-35896-w Published: 12 July 2023 Gulf War illness (GWI) is an important exemplar of environmentally-triggered chronic multisymptom illness, and a...
    • rvallee
    • Thread
    • gulf war illness gwi mitochondria mitochondrial dysfunction
    • Replies: 9
    • Forum: Gulf War Illness
  20. SNT Gatchaman

    Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact, 2020, Silveira et al.

    Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact Willian A. da Silveira; Hossein Fazelinia; Sara Brin Rosenthal; Evagelia C. Laiakis; Man S. Kim; Cem Meydan; Yared Kidane; Komal S. Rathi; Scott M. Smith; Benjamin Stear; Yue Ying...
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