Metabolism and Innate Immunity Meet at the Mitochondria
Bahat, A., MacVicar, T., & Langer, T
Abstract
Mitochondria are master regulators of metabolism and have emerged as key signalling organelles of the innate immune system. Each mitochondrion harbours potent agonists of inflammation...
The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders
Missiroli S, Genovese I, Perrone M, Vezzani B, Vitto VAM, Giorgi C
Abstract
The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell...
Muscle Abnormalities in Nonhospitalised Patients With Post–COVID-19 Condition
BACKGROUND
Post-COVID condition (PCC) affects ~10% of SARS-CoV-2–infected individuals and manifests as persistent symptoms such as fatigue, exercise intolerance and muscle weakness. This study aimed to assess the...
The power and potential of mitochondria transfer
Borcherding N, Brestoff JR.
Preface
Mitochondria are believed to have originated through an ancient endosymbiotic process in which proteobacteria were captured and co-opted for energy production and cellular metabolism. Mitochondria segregate...
Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability
Kim, Haeun; Tian, Ya-Min; Ratcliffe, Peter J; Keeley, Thomas P
Selected proteins containing an N-terminal cysteine (Nt-Cys) are subjected to rapid, O2-dependent proteolysis via the Cys/Arg-branch of the...
Mitochondrial activity tunes nociceptor resilience to excitotoxicity
Lin Yuan; Navdeep S Chandel; David Julius
The capsaicin receptor, TRPV1, mediates the detection of noxious chemical and thermal stimuli by nociceptors, primary sensory neurons of the pain pathway. Overactivation of TRPV1 leads...
Interferon-Linked Lipid and Bile Acid Imbalance Uncovered in Ankylosing Spondylitis in a Sibling-Controlled Multi-Omics Study
Ankylosing spondylitis (AS) displays wide inter-patient variability that is not accounted for by HLA-B27 alone, suggesting that additional immune and metabolic...
A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease
Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory mechanisms and pathological implications remain poorly understood. Here, via...
Metabolic adaptation and fragility in healthy 3-D in vitro skeletal muscle tissues exposed to Chronic Fatigue Syndrome and Long COVID-19 sera.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID-19 (LC-19) are complex conditions with no diagnostic markers or consensus on...
The Roles of Lactate and Lactylation in Diseases Related to Mitochondrial Dysfunction
Ma, Fei; Yu, Wei
Glycolysis and oxidative phosphorylation are the main pathways of cellular energy production. Glucose is metabolized via glycolysis to generate pyruvate, which, under anaerobic conditions, is...
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Laura F. DiGiovanni; Prabhsimran K. Khroud; Ruth E. Carmichael; Tina A. Schrader; Shivneet K. Gill; Kyla Germain; Robert Y. Jomphe; Christoph Wiesinger; Maxime Boutry; Maki Kamoshita; Daniel Snider; Garret Stubbings...
Abstract
The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and...
Endothelial TERT drives microvascular phenotype associated with coronary artery disease
Erin C. Birch; Yoshinori Nishijima; Shelby N. Hader; Andreas M. Beyer
Microvascular endothelial dysfunction is a powerful predictor of future atherosclerotic cardiac events. Our previous studies revealed...
https://www.preprints.org/manuscript/202507.0058/v1
Abstract
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating, multi-system disease characterized by profound fatigue, post-exertional malaise (PEM), and a constellation of immune, neurological, and autonomic symptoms...
Electron-Microscopic Investigation of Muscle Mitochondria in Chronic Fatigue Syndrome
Audrius V. Plioplys; Sigita Plioplys
Abstract
Patients with chronic fatigue syndrome (CFS) suffer from disabling physical and mental fatigue. Abnormalities in mitochondrial function can lead to fatigue and...
Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise
Jin Ma; Annie Yujin Son; Youlim Son; Ping-yuan Wang; Paul M. Hwang
Exercise-induced inflammation is regarded as a response to muscle damage from mechanical stress, but controlled immune signaling can be beneficial...
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