microbiome

Highlights Muscle injury induces local accumulation of RORγ+ Treg cells emanating from the gut The microbiota regulates muscle repair via RORγ+ Treg cells Muscle RORγ+ Treg cells shield differentiating muscle stem cells from IL-17A RORγ+ Treg cell emissaries play a general role in the...

An increasingly complex view of intestinal motility Rao M Key studies published in 2019 shed new light on how complex motor patterns emerge from the functional organization of circuits in the enteric nervous system and, in turn, how extrinsic afferent neurons and common commensal microorganisms...

Abstract Multiple sclerosis (MS) is a T cell-driven autoimmune disease that attacks the myelin of the central nervous system (CNS) and currently has no cure. MS etiology is linked to both the gut flora and external environmental factors but this connection is not well understood. One immune...

Exercise exerts a wide range of beneficial effects for healthy physiology1. However, the mechanisms regulating an individual’s motivation to engage in physical activity remain incompletely understood. An important factor stimulating the engagement in both competitive and recreational exercise...

Abstract Background The gut microbiome plays an important role in autoimmunity including multiple sclerosis and its mouse model called experimental autoimmune encephalomyelitis (EAE). Prior studies have demonstrated that the multiple sclerosis gut microbiota can contribute to disease, hence...

Highlights Randomized-controlled trial on the effects of non-nutritive sweeteners in humans Sucralose and saccharin supplementation impairs glycemic response in healthy adults Personalized effects of non-nutritive sweeteners on microbiome and metabolome Impacts on the microbiome are causally...

Abstract Gulf War Illness (GWI) affects 25–35% of the 1991 Gulf War Veteran (GWV) population. Patients with GWI experience pain, fatigue, cognitive impairments, gastrointestinal dysfunction, skin disorders, and respiratory issues. In longitudinal studies, many patients with GWI have shown little...

Gut microbiota from patients with mild COVID-19 cause alterations in mice that resemble post-COVID syndrome Viviani Mendes de Almeida, Daiane F Engel, Mayra Fernanda Ricci, Clênio Silva Cruz, Icaro Santos Lopes, Daniele Almeida Alves, Mirna d’ Auriol, João Magalhães, Giuliana S. Zuccoli, Bradley...

Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells, and microbiota Yunke Li, Ning Liu, Yao Ge, Ying Yang, Fazheng Ren, Zhenlong Wu Abstract The intestinal mucosal barrier is critical for the absorption of nutrients and the health of both...

Abstract The human large intestinal microbiota thrives on dietary carbohydrates that are converted to a range of fermentation products. Short-chain fatty acids (acetate, propionate and butyrate) are the dominant fermentation acids that accumulate to high concentrations in the colon and they...

Abstract Background: Long-term complications after COVID-19 are common, but the potential cause for persistent symptoms after viral clearance remains unclear. Objective: To investigate whether gut microbiome composition is linked to post-acute COVID-19 syndrome (PACS), defined as at least one...

https://www.nature.com/articles/s41564-021-01043-2 (Paragraph breaks added for legibility, Paywalled unfortunately) The respiratory tract is populated by a specialized microbial ecosystem, which is seeded during and directly following birth. Perturbed development of the respiratory microbial...

Myalgic encephalomyelitis (ME) or Chronic Fatigue Syndrome (CFS) is a neglected, debilitating multi-systemic disease without diagnostic marker or therapy. Despite evidence for neurological, immunological, infectious, muscular and endocrine pathophysiological abnormalities, the etiology and a...

Cognitive behavioral therapy for irritable bowel syndrome induces bidirectional alterations in the brain-gut-microbiome axis associated with gastrointestinal symptom improvement Abstract Background There is growing recognition that bidirectional signaling between the digestive tract and the...

In mice. Abstract Objective Idiopathic Parkinson’s disease (PD) is characterised by alpha-synuclein (aSyn) aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits that PD may initiate in the gut by microbes or their toxins that promote chronic gut inflammation...

In mice. Highlights Altered metabolic features of microglia in the absence of host microbiota Bacteria-derived acetate modulates metabolic features of microglia during steady state Acetate regulates microglial functions during neurodegeneration Summary As tissue macrophages of the central...

Autism-related dietary preferences mediate autism-gut microbiome associations. Chloe X. Yap, Anjali K. Henders, Gail A. Alvares, Andrew J.O. Whitehouse, Naomi R. Wray, Jacob Gratten Summary There is increasing interest in the potential contribution of the gut microbiome to autism spectrum...

Study now published, see https://www.s4me.info/threads/preprint-deficient-butyrate-producing-capacity-in-the-gut-microbiome-of-me-cfs-patients-is-associated-with-fatigue-symptoms-2021-guo-lipkin-et-al.23117/#post-459929 for abstract and link. Preprint: Deficient butyrate-producing capacity in...

Study now printed, see https://www.s4me.info/threads/preprint-multi-omics-of-host-microbiome-interactions-in-short-and-long-term-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-2021-xiong.23022/#post-459931 for abstract and link Preprint: Multi-omics of host-microbiome interactions in...

ME Action doesn't let me copy the text, so here is the link with the details: https://www.meaction.net/2021/10/19/stanford-study-enrolling-now/ In short: It's Ron Davis's lab, they are looking for severely ill, mostly bed-bound people from the US. What is needed: fecal swab sent by mail +...