microbiome

Hi everybody, I finally have the ethics in place to begin recruiting for our recently funded Mason Foundation study. ICC criteria. Healthy controls and pwME in VIC, Australia. Involves some questionaires and a blood and feces collection. We will home visit severely affected people. Primary...

https://www.medrxiv.org/content/10.1101/2024.04.23.24306162v1 An approach to finding specific forms of dysbiosis that associate with different disorders Jonathan Williams, Inga Williams, Karl Morten, Julian Kenyon doi: https://doi.org/10.1101/2024.04.23.24306162 This article is a preprint...

Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous disorder with elusive causes, but most likely because of clinical and other biological factors. As a vital environmental factor, the gut microbiome is increasingly emphasized in various refractory diseases...

Link to post with published version Preprint Abstract Here, we describe the “Obelisks,” a previously unrecognised class of viroid-like elements that we first identified in human gut metatranscriptomic data. “Obelisks” share several properties: (i) apparently circular RNA ∼1kb genome...

Summary Background Post-acute COVID-19 syndrome (PACS) affects over 65 million individuals worldwide but treatment options are scarce. We aimed to assess a synbiotic preparation (SIM01) for the alleviation of PACS symptoms. Methods In this randomised, double-blind, placebo-controlled trial at a...

Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping Siebieszuk, Adam; Sejbuk, Monika; Witkowska, Anna Maria The recently observed circadian oscillations of the intestinal microbiota underscore the profound nature of the...

The lung microbiome regulates brain autoimmunity Hosang, Leon; Canals, Roger Cugota; van der Flier, Felicia Joy; Hollensteiner, Jacqueline; Daniel, Rolf; Flügel, Alexander; Odoardi, Francesca Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated autoimmune...

Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV Irini Sereti; Myrthe L. Verburgh; Jacob Gifford; Alice Lo; Anders Boyd; Eveline Verheij; Aswin Verhoeven; Ferdinand W.N.M. Wit; Maarten F. Schim van der Loeff; Martin Giera...

Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19 Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic immune activation. Whether persistent pathobiont colonization during immune alterations and...

Thought this was an interesting small study. Gut microbiota modulate distal symmetric polyneuropathy in patients with diabetes Junpeng Yang 7 Xueli Yang 7 Guojun Wu 7 Faming Zhang Chenhong Zhang Huijuan Yuan 8 Open Access Published:July 13, 2023...

Abstract Germ-free (GF) mice, which are depleted of their resident microbiota, are the gold standard for exploring the role of the microbiome in health and disease; however, they are of limited value in the study of human-specific pathogens because they do not support their replication. Here...

Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome Abstract Background Gastrointestinal disturbances are among symptoms commonly reported by individuals diagnosed with myalgic encephalomyelitis/chronic fatigue...

Objective Whereas genetic susceptibility for systemic lupus erythematosus (SLE) has been well explored, the triggers for clinical disease flares remain elusive. To investigate relationships between microbiota community resilience and disease activity, we performed the first longitudinal...

Often dismissed by the medical establishment, people with complex illnesses such as ME and long Covid are taking the hunt for treatments into their own hands In 2019, years after developing the myalgic encephalomyelitis (ME/CFS) that had kept her bedridden in a state of chronic pain and...

Suppressed immune and metabolic responses to intestinal damage-associated microbial translocation in myalgic encephalomyelitis/chronic fatigue syndrome Uhde; Indart; Green; Yolken; Cook; Shukla; Vernon; Alaedini The etiology and mechanism of myalgic encephalomyelitis/chronic fatigue syndrome...

The final, formatted version of the article will be published soon. Background: Evidence from previous studies have implicated an important association between gut microbiota (GM) and Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS), but whether there is a definite causal...

Background Hydrogen gas (H2) is a common product of carbohydrate fermentation in the human gut microbiome and its accumulation can modulate fermentation. Concentrations of colonic H2 vary between individuals, raising the possibility that H2 concentration may be an important factor...

Full title: Investigating antibody reactivity to the intestinal microbiome in severe myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Preprint Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystemic disease of unknown aetiology that is characterised...

Abstract Background Growing evidence has suggested that gut microbiota is closely related to the risk of irritable bowel syndrome (IBS), but whether there is a causal effect remains unknown. We adopted a Mendelian randomization (MR) approach to evaluate the potential causal relationships...

Gut Microbiota Dysbiosis Correlates With Long COVID-19 at One-Year After Discharge Zhang, Dongmei; Zhou, Yaya; Ma, Yanling; Chen, Ping; Tang, Jian; Yang, Bohan; Li, Hui; Liang, Mengyuan; Xue, YuE; Liu, Yao; Zhang, Jianchu; Wang, Xiaorong Background: Long coronavirus disease 2019 (COVID-19) in...