methodology

New blog post about fraud and research misconduct in scientific research. https://mecfsskeptic.com/how-many-scientific-papers-are-fake/ Twitter summary: 1) How many scientific papers are fake? A new review argues that fabrication and falsification of scientific results may be more common...

Methodologic and Policy Efforts to Improve a National Long COVID Study Jason, Leonard A. Researching COVID to Enhance Recovery (RECOVER) is a National Institutes of Health initiative to improve our understanding of recovery after SARS-CoV-2 infection and to prevent and treat Long COVID. For...

Factors associated with placebo response rate in randomized controlled trials of antiseizure medications for focal epilepsy https://onlinelibrary.wiley.com/doi/10.1111/epi.18197 Abstract Objective Randomized controlled trials (RCTs) are necessary to evaluate the efficacy of novel treatments...

The challenge of causation in physical activity research Although advancements such as access to large datasets with device-measured physical behaviour, and advances in statistics, have improved our understanding of the associations between physical activity (PA) and health outcomes, PA research...

For those interested: On Thursday 26 October, 11.00-12.00 PDT, Dr Regina Nuzzo and Dr Kristin Sainani will give a free webinar on what a good clinical trial should look like. I expect it to have a relatively low treshold, followable for beginners as well. I got the invitation as a student of...

Royal Society Open Science Big little lies: a compendium and simulation of p-hacking strategies Angelika M. Stefan and Felix D. Schönbrodt Abstract In many research fields, the widespread use of questionable research practices has jeopardized the credibility of scientific results. One of the...

Abstract In 2016, we published a conceptual framework outlining the conclusions of our work in defining pilot and feasibility studies. Since then, the CONSORT extension to randomised pilot and feasibility trials has been published and there have been further developments in the pilot study...

As the title indicates -- a thread for lay people like me who have no or only superficial knowledge of trial methodology and statistics to ask some basic questions and hopefully get answers from more knowledgeable forum members.

Ensuring the Voice of the Very Severely Affected Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patient Is Heard in Research—A Research Model 25% ME Group Abstract Most of the research about Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has focused on ambulant patients who...

How the Lancet lost our trust Stuart Ritchie The Spectator (UK) 26/06/2021 A few of us have tried to get Ritchie interested in the PACE trial, but he has previously refused. But since it now seems to support his argument, he does cautiously mention it...

Registration and primary outcome reporting in behavioral health trials | BMC Medical Research Methodology | Full Text (biomedcentral.com) Abstract Background Registration of research studies is designed to lock investigators into a data collection and analysis plan before a study starts and...

Interesting article but ironic given the author's role with COPE, which whitewashed PACE, and Cochrane, given the organization's failure to deal with exactly this. Problem is that the people who make those statements only ever apply them to things they don't like, I would bet a good sum that the...

The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent need for improvement Christiaan H. Vinkers, Herm J. Lamberink, Joeri K. Tijdink, Pauline Heus, Lex Bouter, Paul Glasziou, David Moher, Johanna A. Damen...

"Medicine is a practice built on trust—from patients and from society in general—and this is especially true for psychiatry, in which trust has been forfeited in the past. Transparency is the foundation stone of trust. In research, this can be manifest at various stages. Clinical trials and...

https://www.sciencedirect.com/science/article/abs/pii/S0895435620302080

I have just seen this new paper on Twitter. A timely reminder that imaging and the subsequent analysis is not an exact science. https://www.biorxiv.org/content/10.1101/843193v1 Abstract Data analysis workflows in many scientific domains have become increasingly complex and flexible. To assess...

https://psyarxiv.com/t7ev9

Against pandemic research exceptionalism Alex John London, Jonathan Kimmelman https://science.sciencemag.org/content/early/2020/04/22/science.abc1731

https://scienceintegritydigest.com/2020/02/21/the-tadpole-paper-mill/

Abstract https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30036-5/fulltext