mestinon

  1. R

    Acetylcholine and antihistamines

    Hi everyone! I haven’t posted here before but have learnt a lot from reading in the past few years - so thank you! (And please say if I’ve posted anything wrongly, hoping I haven’t!) I’m hoping for some help on a couple of questions revolving around acetylcholine. Quick background: I...
  2. Dolphin

    Trial Report Exercise capacity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) treated with long-term pyridostigmine, 2023, Systrom

    https://erj.ersjournals.com/content/62/suppl_67/PA4639 Exercise capacity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) treated with long-term pyridostigmine Johanna Squires, Sarra Al-Zayer, David Systrom European Respiratory Journal 2023 62: PA4639; DOI...
    • Dolphin
    • Thread
    • exercise physiology mestinon pyridostigmine systrom treatment
    • Replies: 6
    • Forum: ME/CFS research
  3. L

    The LIFT trial (OMF) - Pyridostigmine (mestinon) and Low Dose Naltrexone (LDN)

    Discussion moved from the OMF news thread. Trial details - mestinon and/or LDN https://www.omf.ngo/lift-trial/
  4. Sly Saint

    Neurovascular Dysregulation and Acute Exercise Intolerance in ME/CFS: A Randomized, Placebo-Controlled Trial of Pyridostigmine, 2022, Systrom et al

    ABSTRACT Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by intractable fatigue, post-exertional malaise, and orthostatic intolerance, but its pathophysiology is poorly understood. Pharmacologic cholinergic stimulation was used to test the hypothesis that...
    • Sly Saint
    • Thread
    • acetylcholine exercise physiology mestinon pyridostigmine systrom treatment
    • Replies: 33
    • Forum: ME/CFS research
  5. Sly Saint

    The Exercise Response to Pharmacologic Cholinergic Stimulation in ME/CFS, 2020/21, Systrom, phase2 trial registration

    " Brief Summary: Myalgic encephalomyelitis/Chronic fatigue syndrome (ME/CFS), otherwise known as Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME), is an under-recognized disorder whose cause is not yet understood. Suggested theories behind the pathophysiology of this condition...
    • Sly Saint
    • Thread
    • me/cfs mestinon pyridostigmine pyridostigmine bromide small fiber neuropathy systrom
    • Replies: 7
    • Forum: ME/CFS research
  6. cassava7

    OMF to launch clinical trials on Mestinon & Kynurenine, post-COVID19 study

    From their May Momentum 2020 newsletter & https://www.omf.ngo/maymomentum/ Post-COVID19 study: https://www.omf.ngo/2020/04/26/tracking-covid-19-patients/ Mestinon trial: https://www.omf.ngo/2020/04/26/the-mestinon-clinical-trial-for-me-cfs/ &...
    • cassava7
    • Thread
    • clinical trial covid-19 kynurenine me/cfs mestinon omf post covid-19 syndrome rct
    • Replies: 36
    • Forum: ME/CFS research news
  7. Andy

    GI neuroimmune disruption contributes to Gulf War Illness (2019)

    https://www.sciencedaily.com/releases/2019/02/190221141506.htm
  8. andypants

    Mestinon

    I convinced my GP to let me try Mestinon about 18 months ago, but never got as far as actually trying it until now. I have been holding off because I didn't want to muddle the results by starting it too close to my last rtx dose or while I was starting out on LDN. While LDN is extremely...
  9. rvallee

    David Systrom, researcher, Brigham and Women's Hospital, USA

    Dr. David M. Systrom of Brigham and Women’s Hospital (Boston) is confident that his team has objective evidence of small-fiber polyneuropathy (SFPN) in 40-50% of ME patients. Dr Systrom was interviewed by Llewelyn King in this video: . I put the timestamp at the part involved with SFPN but the...
    • rvallee
    • Thread
    • cpet mestinon pem plasmapheresis pots preload failure pyridostigmine sfpn small fiber neuropathy systrom
    • Replies: 96
    • Forum: ME/CFS research news
  10. Dolphin

    Exercise Intolerance in Preload Failure Treated with Pyridostigmine (2018) Faria Urbina et al (mentions ME/CFS & POTS)

    American Journal of Respiratory and Critical Care Medicine 2018;197:A6146 Exercise Intolerance in Preload Failure Treated with Pyridostigmine M. Faria Urbina 1, R. Oliveira 2, A.L. Oaklander 3, A.B. Waxman 1, D.M. Systrom 1...
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