Tale of two systems: the intertwining duality of fibrinolysis and lipoprotein metabolism
Wen Dai; Mark Castleberry; Ze Zheng
Fibrinolysis is an enzymatic process that breaks down fibrin clots, while dyslipidemia refers to abnormal levels of lipids and lipoproteins in the blood. Both...
Circulating Metabolome and White Matter Hyperintensities in Women and Men
Eeva Sliz; Jean Shin; Shahzad Ahmad; Dylan M. Williams; Stefan Frenzel; Friederike Gauß; Sarah E. Harris; Ann-Kristin Henning; Maria Valdes Hernandez; Yi-Han Hu; Beatriz Jiménez; Muralidharan Sargurupremraj; Carole Sudre...
A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants
Farley, Scotland E.; Kyle, Jennifer E.; Leier, Hans C.; Bramer, Lisa M.; Weinstein, Jules B.; Bates, Timothy A.; Lee, Joon-Yong; Metz, Thomas O.; Schultz, Carsten; Tafesse, Fikadu G.
A comprehensive...
Metabolomic Signatures of Sedentary Behavior and Cardiometabolic Traits in US Hispanics/Latinos: Results from HCHS/SOL
Moon, Jee-Young;Chai, Jin Choul;Yu, Bing;Song, Rebecca J.;Chen, Guo-Chong;Graff, Mariaelisa;Daviglus, Martha L.;Chan, Queenie;Thyagarajan, Bharat;Castaneda, Sheila F.;Grove...
Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response MERSR and its Impact on Proteostasis
Jeson J Li; Nan Xin; Chunxia Yang; Larrisa A Tavizon; Ruth Hong; Travis I Moore; Rebecca G Tharyan; Adam Antebi; Hyun-Eui Kim
Maintaining protein homeostasis is essential...
Attenuation of ferroptosis as a potential therapeutic target for neuropsychiatric manifestations of post-COVID syndrome
Sousa, Ricardo A. L.; Yehia, Asmaa; Abulseoud, Osama A.
Coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), is...
Extracellular vesicles promote autophagy in human microglia through lipid raft-dependent mechanisms
Diana Romenskaja; Ugne Jonavice; Augustas Pivoriunas
Autophagy dysfunction has been closely related with pathogenesis of many neurodegenerative diseases and therefore represents a potential...
Associations of circulating metabolites with cerebral white matter hyperintensities
Yan Sun; Yu Guo; Hong-Qi Li; Lan Tan; Jian-Feng Feng; Wei Cheng; Jin-Tai Yu
White matter hyperintensities (WMH) are the most compelling risk factors of stroke, dementia, and early mortality. We aimed to...
High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner
Correa; Del Giudice; Waldie; Thépaut; Micciula; Gerelli; Moulin; Delaunay; Fieschi; Pichler; Haertlein; Forsyth; Le Brun; Moir; Russell; Darwish; Brinck; Wodaje; Jansen; Martín...
Full title:
Clinical improvement of Long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis
Abstract
In the aftermath of the COVID-19 pandemic, we are witnessing an unprecedented wave of post-infectious complications. Most...
Significance
Chronic fatigue syndrome is a multisystem disease that causes long-term pain and disability. It is difficult to diagnose because of its protean symptoms and the lack of a diagnostic laboratory test. We report that targeted, broad-spectrum metabolomics of plasma not only revealed a...
Introduction: Similar to what it has been reported with preceding viral epidemics (such as MERS, SARS, or influenza), SARS-CoV-2 infection is also affecting the human immunometabolism with long-term consequences. Even with underreporting, an accumulated of almost 650 million people have been...
Immunometabolic rewiring in long COVID patients with chronic headache
Suan-Sin Foo, Weiqiang Chen, Kyle L Jung, Tamiris Azamor, Un Yung Choi, Pengfei Zhang, Suzy AA Comhair, Serpil C Erzurum, Lara Jehi, Jae U Jung
Almost 20% of patients with COVID-19 experience long-term effects, known as...
Myelin lipid metabolism and its role in myelination and myelin maintenance
Barnes-Vélez JA, Aksoy Yasar FB, Hu J
Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin's salient features that contribute to its...
Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis
Allen CNS, Arjona SP, Santerre M, Sawaya BE
Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral infections. Metabolic reprogramming provides the cell with energy and biomass for...
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