lipids

Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes Nathan G. Lawler; Lael M. Yonker; Samantha Lodge; Philipp Nitschke; Maureen M. Leonard; Nicola Gray; Luke Whiley; Reika Masuda; Elaine Holmes; Julien Wist; Alessio Fasano; Jeremy...

Longitudinal lipoprotein and inflammatory mediators analysis uncover persisting inflammation and hyperlipidemia following SARS-CoV-2 infection in long COVID-19 Bae, Gyuntae; Yang, Zhiqi; Bucci, Daniele; Wegner, Claire; Schäfer, Hartmut; Singh, Yogesh; Lonati, Caterina; Trautwein, Christoph...

Cell membranes sustain phospholipid imbalance via cholesterol asymmetry Milka Doktorova; Jessica L. Symons; Xiaoxuan Zhang; Hong-Yin Wang; Jan Schlegel; Joseph H. Lorent; Frederick A. Heberle; Erdinc Sezgin; Edward Lyman; Kandice R. Levental; Ilya Levental Membranes are molecular interfaces...

A research perspective on sphingolipid metabolism and myalgic encephalomyelitis/chronic fatigue syndrome Xiao, Junhua No abstract. Link | PDF (Neural Regeneration Research)

Reversible reduction in brain myelin content upon marathon running Ramos-Cabrer, Pedro; Cabrera-Zubizarreta, Alberto; Padro, Daniel; Matute-González, Mario; Rodríguez-Antigüedad, Alfredo; Matute, Carlos Here we use magnetic resonance imaging to study the impact of marathon running on brain...

Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...

Abstract: We proposed that cerebrospinal fluid would provide objective evidence for disrupted brain metabolism in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS). The concept of postexertional malaise (PEM) with disabling symptom exacerbation after limited exertion that does not...

Integrative Multi-Omics Framework for Causal Gene Discovery in Long COVID Thuc Duy Le, Sindy Licette Pinero, Xiaomei Li, Lin Liu, Jiuyong Li, Sang Hong Lee, Marnie Winter, Thin Nguyen, Junpeng Zhang Background Long COVID, or Post–Acute Sequelae of COVID–19 (PASC), involves persistent...

Highlights •FM patients have higher anti-SGC IgG levels associated with pain intensity •FM patients have lower levels of phospholipid classes, sphingomyelin, and triglycerides •FM patients have higher levels of diglycerides •FM severe have higher levels of some lysophosphatidylcholines than FM...

Exertional Exhaustion Post-Exertional Malaise, PEM Evaluated by the Effects of Exercise on Cerebrospinal Fluid Metabolomics–Lipidomics and Serine Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Baraniuk, James N. Post-exertional malaise (PEM) is a defining condition of myalgic...

Long-term dysregulation of plasma peptidome in mild and multiple COVID-19 recovered patients revealed by a novel efficient peptidomics workflow Song, Zhijing; Liu, Chaoran; Liu, Yaozhou; Bian, Zheng; Sun, Qing; He, Ting; Su, Rong; Huang, Shengchun; Dai, Ningbin; Zhao, Ke li; Li, Yan; Liang, Kai...

Lipid storage myopathy associated with sertraline treatment is an acquired mitochondrial disorder with respiratory chain deficiency Hedberg-Oldfors, Carola; Lindgren, Ulrika; Visuttijai, Kittichate; Shen, Yan; Ilinca, Andreea; Nordström, Sara; Lindberg, Christopher; Oldfors, Anders Lipid...

Katherine Huang, Alex G. C. de Sá, Natalie Thomas, Robert D. Phair, Paul R. Gooley, David B. Ascher & Christopher W. Armstrong Abstract Background Diagnosing complex illnesses like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is complicated due to the diverse symptomology and...

A six-year study in a real-world population reveals an increased incidence of dyslipidemia during COVID-19 Valentina Trimarco; Raffaele Izzo; Stanislovas S. Jankauskas; Mario Fordellone; Giuseppe Signoriello; Maria Virginia Manzi; Maria Lembo; Paola Gallo; Giovanni Esposito; Roberto Piccinocchi...

There is compelling evidence that a dysregulated immune inflammatory response in neuroinfectious diseases results in modifications in metabolic processes and altered metabolites, directly or indirectly influencing lipid metabolism within the central nervous system (CNS). The challenges in...

Targeted metabolomics identifies accurate CSF metabolite biomarkers for the differentiation between COVID-19 with neurological involvement and CNS infections with neurotropic viral pathogens Neu, Frieder; Nay, Sandra; Schuchardt, Sven; Klawonn, Frank; Skripuletz, Thomas; Suehs, Kurt-Wolfram...

https://www.biorxiv.org/content/10.1101/2024.06.24.600378v1 BioMapAI: Artificial Intelligence Multi-Omics Framework Modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome Ruoyun Xiong, Elizabeth Fleming, Ryan Caldwell, Suzanne D. Vernon, Lina Kozhaya, Courtney Gunter, Lucinda...

Quantitative imaging of species-specific lipid transport in mammalian cells Juan M. Iglesias-Artola; Kai Schumann; Kristin Bohlig; H. Mathilda Lennartz; Milena Schumacher; Pavel Barahtjan; Cristina Jiminez Lopez; Radek Sachl; Karina Pombo-Garcia; Annett Lohmann; Petra Riegerova; Martin Hof...

Abstract Background This study investigates the impact of fluctuating lipid levels on endothelial dysfunction. Methods Human aortic and umbilical vein endothelial cells were cultured under varying palmitic acid (PA) concentrations: 0, 50, and 100 μM, and in a variability group alternating...

Targeting the High-Density Lipoprotein Proteome for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Grote, Karsten; Schaefer, Ann-Christin; Soufi, Muhidien; Ruppert, Volker; Linne, Uwe; Mukund Bhagwat, Aditya; Szymanski, Witold; Graumann, Johannes; Gercke, Yana; Aldudak, Sümeya...