interferon

  1. jnmaciuch

    Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis, Chakravarty+

    Interferon-stimulated gene TDRD7 interacts with AMPK and inhibits its activation to suppress viral replication and pathogenesis (2023) Sukanya Chakravarty, Gayatri Subramanian, Sonam Popli, Manoj Veleeparambil, Shumin Fan, Ritu Chakravarti, Saurabh Chattopadhyay Department of Medical...
  2. Hutan

    Neopterin

    Petrichor noted here A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff that some papers have reported elevated levels of neopterin in ME/CFS. That's interesting because macrophages produce neopterin when stimulated with...
  3. Nightsong

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    Abstract: Evidence bearing on possible mechanisms for the clinical syndrome of ME/CFS is reviewed. The evidence is used to argue for a hypothesis that centres on a form of persistent, inappropriate, ‘neuroimmune hypervigilance’ mediated primarily by T lymphocyte-macrophage interaction but...
    • Nightsong
    • Thread
    • cd64 fcγri igg iggr interferon interferon gamma jackie cliff jo cambridge jonathan edwards t cells
    • Replies: 500
    • Forum: ME/CFS research
  4. Jonathan Edwards

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Link to the thread on the preprint - 27 May 2025: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff ****** I am hoping that the paper I have been writing with Jo Cambridge and Jackie Cliff will appear on Qeios tomorrow. If...
  5. SNT Gatchaman

    Longitudinal lipoprotein and inflammatory mediators analysis uncover persisting inflammation and hyperlipidemia…, 2025, Bae+

    Longitudinal lipoprotein and inflammatory mediators analysis uncover persisting inflammation and hyperlipidemia following SARS-CoV-2 infection in long COVID-19 Bae, Gyuntae; Yang, Zhiqi; Bucci, Daniele; Wegner, Claire; Schäfer, Hartmut; Singh, Yogesh; Lonati, Caterina; Trautwein, Christoph...
  6. SNT Gatchaman

    Immune disturbances in individuals with post-COVID syndrome are not characterized by enhanced SARS-CoV-2-specific immunity, 2025, Ober+

    Immune disturbances in individuals with post-COVID syndrome are not characterized by enhanced SARS-CoV-2-specific immunity Ober, Veronica; Völk, Felix; Sbierski-Kind, Julia; Gruener, Eva; Stirner, Renate; Reiling, Gabriele; Feldmann, Svenja; Ibarra, Gerardo; Seybold, Ulrich; Stubbe, Hans...
  7. SNT Gatchaman

    Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID, 2025, Renner et al.

    Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID Renner; Stauffenberg; Paulus; Neumayer; Winter-Köhler; Buchtler; Schmalenberger; Blaas; Mohr; Pfeifer; Malfertheiner; Loew; Sester; Bals; Peterhoff; Schmidt; Mack Following...
  8. forestglip

    [Clinical characteristics and cytokine gene expression in patients with post-COVID-19 syndrome], 2025, Valencia-Gutiérrez et al

    [Clinical characteristics and cytokine gene expression in patients with post-COVID-19 syndrome] María Magdalena Valencia-Gutiérrez , Modesto Gómez-López, Nadia Mabel Pérez-Vielma, Paulina Lázaro-Aguilar, Víctor Ricardo Aguilera-Sosa Background Post-COVID-19 syndrome occurs 3 months after...
  9. Mij

    Itaconate modulates immune responses via inhibition of peroxiredoxin 5, 2025, Tomas Paulenda et al

    Abstract The immunoregulatory metabolite itaconate accumulates in innate immune cells upon Toll-like receptor stimulation. In response to macrophage activation by lipopolysaccharide, itaconate inhibits inflammasome activation and boosts type I interferon signalling; however, the molecular...
  10. Mij

    Itaconate boosts type I IFN response by disrupting cytoprotection, 2025, Theresa Ramalho

    A new study reveals a surprising mechanism by which itaconate inhibits the active site of a peroxiredoxin enzyme to amplify redox signalling and the type I interferon response in macrophages. Paywalled
  11. SNT Gatchaman

    Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine, 2025, Jolink+

    Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine Jolink; Feldman; Antenucci; Cardenas; West; Nakamura; Muscatell The influenza vaccine has reliably been associated with mild, within-person increases in...
  12. SNT Gatchaman

    Preprint Systemic Multi-Omics … Reveals Interferon Response Heterogeneity & Links Lipid Metabolism to Immune Alterations in Severe COVID, 2025, Lira-Junior+

    Systemic Multi-Omics Analysis Reveals Interferon Response Heterogeneity and Links Lipid Metabolism to Immune Alterations in Severe COVID-19 Ronaldo Lira-Junior; Anoop Ambikan; Axel Cederholm; Ssefanit Rezene; Flora Mikaeloff; Sara Svensson Akusjarvi; Ahmet Yalcinkaya; Xi Chen; Maike Sperk...
    • SNT Gatchaman
    • Thread
    • amino acids immunometabolic innate immune response interferon interferon-stimulated genes lipids metabolomics mitochondria monocytes neopterin neutrophils plasmalogen proteomics sphingolipids tryptophan
    • Replies: 1
    • Forum: Long Covid research
  13. SNT Gatchaman

    Preprint Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing, 2025, Spriņģe et al.

    Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing Marta Līva Spriņģe; Kristīne Vaivode; Rihards Saksis; Nineļa Miriama Vainšeļbauma; Laura Ansone; Monta Brīvība; Helvijs Niedra; Vita Rovite Long-COVID affects at least 10% of COVID-19...
  14. SNT Gatchaman

    The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and [vaccination], 2025, Maatz+

    The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination Maatz, Henrike; Lindberg, Eric L.; Adami, Eleonora; López-Anguita, Natalia; Perdomo-Sabogal, Alvaro; Cocera Ortega, Lucía; Patone, Giannino; Reichart...
  15. Mij

    Immunological and clinical markers of PASC: Insights from mild and severe cases six months post-infection, 2025, William Mouton et al

    Abstract Post-acute sequelae of COVID-19 (PASC) is a complex and multifaceted clinical challenge requiring to emphasize its underlying pathophysiological mechanisms. This study assessed hundreds of virological, serological, immunological, and tissue damage biomarkers in two patient cohorts who...
    • Mij
    • Thread
    • cmv cortisol ebv interferon t cells viral persistence
    • Replies: 9
    • Forum: Long Covid research
  16. SNT Gatchaman

    Review Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Syed, Karius, Wang, Hwang

    Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Abu Mohammad Syed; Alexander K. Karius; Jin Ma; Ping-yuan Wang; Paul M. Hwang ME/CFS is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms...
    • SNT Gatchaman
    • Thread
    • actin atp eif2a endoplasmic reticulum er stress interferon jak-stat mitochochria mitochondrial dysfunction nf-κb wasf3
    • Replies: 15
    • Forum: ME/CFS research
  17. SNT Gatchaman

    Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Monocytes, Avoiding [LC], 2025, Olivares-Martínez+

    Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement with LAIR-1 in Circulating Monocytes, Avoiding Long COVID Olivares-Martínez, Elizabeth; Hernández-Ramírez, Diego Francisco; Núñez-Álvarez, Carlos Alberto; Meza-Sánchez, David Eduardo; Chapa, Mónica...
  18. forestglip

    Correlation of Interferons and Autoimmune Aspects in Long COVID-19 Patients, 2025, Hattori et al

    Correlation of Interferons and Autoimmune Aspects in Long COVID-19 Patients Fumiyuki Hattori, Junji Nishiyama, Hideaki Hasuo [Line break added] Abstract Long COVID, or post-acute sequelae of COVID-19 (PASC), represents a major global health challenge, with its underlying mechanisms remaining...
  19. SNT Gatchaman

    Regulation of human interferon signaling by transposon exonization, 2024, Pasquesi et al.

    Regulation of human interferon signaling by transposon exonization Giulia Irene Maria Pasquesi; Holly Allen; Atma Ivancevic; Arturo Barbachano-Guerrero; Olivia Joyner; Kejun Guo; David M. Simpson; Keala Gapin; Isabella Horton; Lily L. Nguyen; Qing Yang; Cody J. Warren; Liliana D. Florea...
  20. SNT Gatchaman

    An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection, 2024, Fenn+

    An ultra-early, transient interferon-associated innate immune response associates with protection from SARS-CoV-2 infection despite exposure Joe Fenn et 77 al BACKGROUND A proportion of individuals exposed to respiratory viruses avoid contracting detectable infection. We tested the hypothesis...
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