insulin

Highlights Mononuclear cells are primary drivers of the exercise response in skeletal muscle • Release of histamine from skeletal muscle during exercise from mast cells • Histamine receptor antagonists impair post-exercise muscle glycogen resynthesis • Exercise-induced transcriptional...

Actively Protective Combinatorial Analysis: a Scalable Novel Method for Detecting Variants that Contribute to Reduced Disease Prevalence in High-Risk Individuals Jason Sardell; Sayoni Das; Krystyna Taylor; Colin Stubberfield; Andy Malinowski; Mark Strivens; Steve Gardner We present a novel...

After the really interesting recent study by @Chris Ponting showing some markers of insulin resistance in ME patients, the question arises, why would the HbA1c not be indicating insulin resistance in these patients? I have seen Continuous Glucose Monitor (CGM) charts of people with ME, and...

I bought a continuous glucose monitor a while ago thinking it could be interesting to try. @TamaraRC 's post has inspired to me to finally put it on. Here's a trace from when I had 5 pieces of a medium pizza yesterday evening (peak on the right): and a relative of mine eating exactly the...

Hello I have been working on an ME Hypothesis for the last few years. It describes three types of noradrenergic neuron dysfunction, two of which are mediated by insulin. Of course, there could be more subtypes not suggested in this hypothesis. I have made a video explaining the hypothesis-...

Epigenetic patterns, accelerated biological aging, and enhanced epigenetic: drift detected 6 months following COVID-19 infection: insights from a genome-wide DNA methylation study, 2024, Calzari Luciano, Dragani Davide Fernando et al Abstract Background The epigenetic status of patients 6-month...

Persistent Activation of Chronic Inflammatory Pathways in Long Covid Malika Aid; Katherine McMahan; Nicole Hachmann; Jessica Miller; Erica Borducchi; David Hope; Marjorie Rowe; Eleanor Schonberg; Siline Thai; Ai-ris Collier; Janet Mullington; Dan Barouch Long Covid, or Post-Acute Sequelae of...

Critical COVID-19 disease is accompanied by depletion of plasma tryptophan (TRY) and increases in indoleamine-dioxygenase (IDO)-stimulated production of neuroactive tryptophan catabolites (TRYCATs), including kynurenine (KYN). The TRYCAT pathway has not been studied extensively in association...

https://www.mdpi.com/2504-3900/80/1/6 Report from the Scientific Poster Session at the 16th Annual Cardiometabolic Health Congress in National Harbor, USA, 14–17 October 2021 [..] 2.12. The Role of Leptin and Inflammatory Related Biomarkers in Individuals with Myalgic...

Abstract Background: Postural tachycardia syndrome (POTS) is characterized by excessive upright tachycardia and disabling presyncopal symptoms, which are exacerbated after consuming a high-carbohydrate meal; it is unknown, however, what is the precise underlying mechanism. We seek to...

Abstract Multiple chemical sensitivity (MCS) is a multisystem syndrome, and limited knowledge of its pathophysiology exists. Based on the population-based Danish cohort DanFunD, this study investigated metabolic health in people with MCS compared to individuals who did not have MCS. From 9656...

Thought his was an interesting presentation, https://mecfsconference.org.au/videos/neil-mcgregor/ As a spoiler, here is his last slide, summarising his main points

Two interesting new studies on how inactivity can have drastic metabolic consequences. Take a Vacation From Exercise? Your Body May Not Thank You This is by no means a suggestion that PWME should be more active, of course adaptive pacing is the best way to go! It just highlights one of the...

Alzheimer's drug development tends to focus on protein aggregates in the brain. And they've all failed. Alzheimer’s disease: why insulin is a new suspect https://theconversation.com/alzheimers-disease-why-insulin-is-a-new-suspect-97222

This research is in its early stages and there are still lots of questions surrounding it. Quoting from a post on another forum A thyroid hormone different from T4 and T3 acts as a control of insulin production by affecting the energy producing factories (mitochondria). Like T4 , the hormone...

Article about analyzing research databases of viral genomic sequences to find viruses that produce peptides similar to human hormones and regulatory proteins. They conclude some of these viruses could be a factor not only in diabetes, but metabolic disease, autoimmune disease, and cancer...