il-6

  1. SNT Gatchaman

    Preprint Alpha7 nicotinic acetylcholine receptor agonist PHA 568487 dampens inflammation in PBMCs from patients with coronary artery disease, 2024, Mjörnstedt+

    Alpha7 nicotinic acetylcholine receptor agonist PHA 568487 dampens inflammation in PBMCs from patients with newly discovered coronary artery disease. Filip Mjörnstedt; Rebecka Wilhelmsson; Marcus Ulleryd; Maria Hammarlund; Göran Bergström; Anders Gummesson; Maria E Johansson BACKGROUND The...
  2. SNT Gatchaman

    Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α, 2024, Queiroz et al.

    Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α Queiroz, Maria Alice Freitas; Brito, Wandrey Roberto dos Santos; Pereira, Keise Adrielle Santos; Pereira, Leonn Mendes Soares; Amoras, Ednelza da Silva Graça; Lima, Sandra Souza; Santos, Erika Ferreira...
  3. SNT Gatchaman

    Cytokines IL1β, IL6, TNFα & serum cortisol may not constitute reliable biomarkers to identify [PASC], 2024, Fleischer, Kleinschnitz et al.

    Cytokines IL1β, IL6, TNFα and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19 Michael Fleischer; Fabian Szepanowski; Anne K Mausberg; Livia Asan; Ellen Uslar; Denise Zwanziger; Lothar Volbracht; Mark Stettner; Christoph...
  4. SNT Gatchaman

    Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes, 2024, Zhang et al.

    Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes Zhang, Yue; Bharathi, Vanthana; Dokoshi, Tatsuya; de Anda, Jaime; Ursery, Lauryn Tumey; Kulkarni, Nikhil N.; Nakamura, Yoshiyuki; Chen, Jonathan; Luo, Elizabeth W...
    • SNT Gatchaman
    • Thread
    • amyloid antimicrobial peptides cathelicidin il-6 inflammation mmp-9 molecular mimicry pamps sars-cov-2 transcriptome
    • Replies: 12
    • Forum: Long Covid research
  5. SNT Gatchaman

    Near-Infrared Light Exposure Triggers ROS to Downregulate Inflammatory Cytokines Induced by SARS Spike Protein in Human Cell Culture, 2023, Aguida +

    Near-Infrared Light Exposure Triggers ROS to Downregulate Inflammatory Cytokines Induced by SARS-CoV-2 Spike Protein in Human Cell Culture Aguida, Blanche; Chabi, Marie-Marthe; Baouz, Soria; Mould, Rhys; Bell, Jimmy D.; Pooam, Marootpong; André, Sebastien; Archambault, Dominique; Ahmad...
  6. SNT Gatchaman

    Preliminary Evidence of the Differential Expression of HERVs in Kawasaki Disease and SARS-CoV-2-Associated MIS-C, 2023, Balestrieri et al.

    Preliminary Evidence of the Differential Expression of Human Endogenous Retroviruses in Kawasaki Disease and SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children Balestrieri, Emanuela; Corinaldesi, Elena; Fabi, Marianna; Cipriani, Chiara; Giudice, Martina; Conti, Allegra...
    • SNT Gatchaman
    • Thread
    • children herv herv-k herv-w il-6 kawasaki mis-c nf-κb retrovirus sars-cov-2 spike protein syncitin tlr-4
    • Replies: 0
    • Forum: Long Covid research
  7. SNT Gatchaman

    Preprint A 50-gene high-risk profile predictive of COVID & pulmonary fibrosis mortality from molecular imbalance in monocyte & T-cell subsets, 2023, Tourki +

    A 50-gene high-risk profile predictive of COVID-19 and Idiopathic Pulmonary Fibrosis mortality originates from a molecular imbalance in monocyte and T-cell subsets that reverses in survivors with post-COVID-19 Interstitial Lung Disease Bochra Tourki; Minxue Jia; Theodoros Karampitsakos; Iset M...
    • SNT Gatchaman
    • Thread
    • cd163 fibrosis gene expression hspc il-6 ild ipf lung fibrosis lungs monocytes pbmc sars-cov-2 tgf-beta
    • Replies: 2
    • Forum: Long Covid research
  8. SNT Gatchaman

    Preprint SARS-CoV-2 induces acute neurological signs while CGRP signaling blockade reduces IL-6 release and weight loss in mouse models, 2023, Rahman et al.

    SARS-CoV-2 induces acute neurological signs while Calcitonin Gene-Related Peptide CGRP signaling blockade reduces interleukin 6 IL-6 release and weight loss in mouse models Shafaqat M Rahman; David W Buchholz; Brian Imbiakha; Mason C Jaeger; Justin Leach; Raven M Osborn; Ann O Birmingham...
  9. SNT Gatchaman

    A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling, 2023, Hackney et al.

    A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with...
  10. SNT Gatchaman

    COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory cytokines/SGLT2 pro-oxidant pathway, 2023, Mroueh et al.

    COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory cytokines/SGLT2 pro-oxidant pathway Ali Mroueh; Walaa Fakih; Adrien Carmona; Antonin Trimaille; Kensuke Matsushita; Benjamin Marchandot; Abdul Wahid Qureshi; Dal-Seong Gong; Cyril Auger; Laurent Sattler...
    • SNT Gatchaman
    • Thread
    • coagulation covid-19 cytokines endothelial dysfunction enos il-1b il-6 nf-κb nitric oxide oxidative stress platelets redox tnf
    • Replies: 0
    • Forum: Long Covid research
  11. SNT Gatchaman

    Early antibody treatment, inflammation, and risk of post-COVID conditions, 2023, Gebo et al.

    Early antibody treatment, inflammation, and risk of post-COVID conditions Kelly A. Gebo; Sonya L. Heath; Yuriko Fukuta; Xianming Zhu; Sheriza Baksh; Allison G. Abraham; Feben Habtehyimer; David Shade; Jessica Ruff; Malathi Ram; Oliver Laeyendecker; Reinaldo E. Fernandez; Eshan U. Patel; Owen R...
  12. SNT Gatchaman

    Epigenetic memory of coronavirus infection in innate immune cells and their progenitors, 2023, Cheong et al.

    Epigenetic memory of coronavirus infection in innate immune cells and their progenitors Jin-Gyu Cheong; Arjun Ravishankar; Siddhartha Sharma; Christopher N. Parkhurst; Simon A. Grassmann; Claire K. Wingert; Paoline Laurent; Sai Ma; Lucinda Paddock; Isabella C. Miranda; Emin Onur Karakaslar...
    • SNT Gatchaman
    • Thread
    • bone marrow covid-19 epigenetics haematopoietic stem cell progenitors hspc il-6 immune dysfunction innate immune system monocytes stem cells trained innate immunity
    • Replies: 6
    • Forum: Long Covid research
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    Early Biological Markers of Post-Acute Sequelae of SARS-CoV-2 Infection, 2024, Lu, Peluso et al

    Link to published version here Preprint Abstract To understand the roles of acute phase viral dynamics and host immune responses in PASC, we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR. Participants self-collected nasal specimens up to 21 times...
    • EndME
    • Thread
    • ifna il-10 il-6 interferon ip-10 long covid longitudinal mcp-1 peluso prospective tnfa
    • Replies: 2
    • Forum: Long Covid research
  14. Mij

    Neuro-PASC is characterized by enhanced CD4+ and diminished CD8+ T cell responses to SARS-CoV-2 Nucleocapsid protein, 2023, Lavanya Visvabharathy

    Introduction: Many people with long COVID symptoms suffer from debilitating neurologic post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC). Although symptoms of Neuro-PASC are widely documented, it is still unclear whether PASC symptoms impact virus-specific immune responses. Therefore, we...
  15. Andy

    Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19 2023 Freidin, Pariante, Williams et al

    Abstract Objective and design: Fatigue is a prominent symptom in the general population and may follow viral infection, including SARS-CoV2 infection which causes COVID-19. Chronic fatigue lasting more than three months is the major symptom of the post-COVID syndrome (known colloquially as...
  16. SNT Gatchaman

    Endometriosis leads to central nervous system-wide glial activation in a mouse model of endometriosis, 2023, Bashir et al.

    Endometriosis leads to central nervous system-wide glial activation in a mouse model of endometriosis Bashir, Shah Tauseef; Redden, Catherine R.; Raj, Kishori; Arcanjo, Rachel B.; Stasiak, Sandra; Li, Quanxi; Steelman, Andrew J.; Nowak, Romana A. Chronic pelvic pain (CPP) is a common symptom of...
  17. Mij

    Cytokine deficiencies in patients with Long-COVID, 2022, Vicente Planelles et al

    Preprint Plasma cytokine levels reveal deficiencies in IL-8 and gamma interferon in Long-COVID, 2022, Elizabeth S C P Williams et al See post #8 for published version Abstract Up to half of individuals who contract SARS-CoV-2 develop symptoms of long-COVID approximately three months after...
    • Mij
    • Thread
    • cytokines il-13 il-17 il-2 il-4 il-6 il-8 long covid
    • Replies: 11
    • Forum: Long Covid research
  18. Mij

    Plasma Markers of Neurologic Injury and Inflammation in People With ... Neurologic Post acute Sequelae of SARS-CoV-2 Infection, 2022, Peluso et al

    Plasma Markers of Neurologic Injury and Inflammation in People With Self-Reported Neurologic Post acute Sequelae of SARS-CoV-2 Infection, 2022, Michael J. Peluso et al Abstract Background and Objectives The biologic mechanisms underlying neurologic post acute sequelae of severe acute...
  19. Mij

    Post-acute sequelae and adaptive immune responses in people living with HIV recovering from SARS-COV-2 infection, 2022, Peluso, Michael et al

    Abstract Background: Limited data are available on the long-term clinical and immunologic consequences of SARS-CoV-2 infection in people with HIV (PWH). Methods: We measured SARS-CoV-2-specific humoral and cellular responses in people with and without HIV recovering from COVID-19 (n = 39 and...
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    Open Australia (SA) SAHMRI Biomarkers for ME/CFS ('Good Day/Bad Day' Study)

    https://mecfssa.org.au/news-events/current-sa-research SAHMRI Biomarkers for ME/CFS Study 2: 'Good Day/Bad Day' Study This research is a multidisciplinary approach to investigate ME/CFS which aims to take some blood, urine and faecal samples from 60 people (including 20 healthy controls)...
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