Abstract
Evidence linking the endothelium to cardiac injury in long coronavirus disease (COVID) is well documented, but the underlying mechanisms remain unknown.
Here we show that cytokines released by endothelial cells (ECs) contribute to long-COVID-associated cardiac dysfunction. Using...
Effects of physical training on coagulation parameters, interleukin-6, and angiotensin-converting enzyme-2 in COVID-19 survivors
Binabaji, Soheila; Rahimi, Mohammad; Rajabi, Hamid; Keshavarz, Mohsen; Rahimi, Rahimeh; Ahmadi, Azam; Gahreman, Daniel
COVID-19 is a highly contagious virus that uses...
Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS)
Anna Katharina Mundorf, Amelie Semmler, Harald Heidecke, Matthias Schott, Falk Steffen, Stefan Bittner, Karl J. Lackner, Karin Schulze-Bosse, Marc Pawlitzki, Sven Guenther Meuth, Frank Klawonn, Jana Ruhrländer...
Tocilizumab Reduces Hypercoagulation in COVID-19 - Perspectives from The Coagulation and Immunomodulation Covid Assessment Coag-ImmCovA Clinical Trial.
Lou M Almskog; Anna Sjostrom; Jonas Sunden-Cullberg; Apostolos Taxiarchis; Anna Agren; Sara Freyland; Madeleine Borjesson; Agneta Wikman; Carl...
Extreme γ′ fibrinogen levels in COVID-19 patients
Hudkins; Hamilton; Underwood; Kazmierczak; Dewey; Kazmierczak; Messer; Khan; Schreiber; Farrell
COVID-19 disease progression can be accompanied by a “cytokine storm” that leads to secondary sequelae such as acute respiratory distress syndrome...
Alpha7 nicotinic acetylcholine receptor agonist PHA 568487 dampens inflammation in PBMCs from patients with newly discovered coronary artery disease.
Filip Mjörnstedt; Rebecka Wilhelmsson; Marcus Ulleryd; Maria Hammarlund; Göran Bergström; Anders Gummesson; Maria E Johansson
BACKGROUND
The...
Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α
Queiroz, Maria Alice Freitas; Brito, Wandrey Roberto dos Santos; Pereira, Keise Adrielle Santos; Pereira, Leonn Mendes Soares; Amoras, Ednelza da Silva Graça; Lima, Sandra Souza; Santos, Erika Ferreira...
Cytokines IL1β, IL6, TNFα and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19
Michael Fleischer; Fabian Szepanowski; Anne K Mausberg; Livia Asan; Ellen Uslar; Denise Zwanziger; Lothar Volbracht; Mark Stettner; Christoph...
Preliminary Evidence of the Differential Expression of Human Endogenous Retroviruses in Kawasaki Disease and SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children
Balestrieri, Emanuela; Corinaldesi, Elena; Fabi, Marianna; Cipriani, Chiara; Giudice, Martina; Conti, Allegra...
A 50-gene high-risk profile predictive of COVID-19 and Idiopathic Pulmonary Fibrosis mortality originates from a molecular imbalance in monocyte and T-cell subsets that reverses in survivors with post-COVID-19 Interstitial Lung Disease
Bochra Tourki; Minxue Jia; Theodoros Karampitsakos; Iset M...
SARS-CoV-2 induces acute neurological signs while Calcitonin Gene-Related Peptide CGRP signaling blockade reduces interleukin 6 IL-6 release and weight loss in mouse models
Shafaqat M Rahman; David W Buchholz; Brian Imbiakha; Mason C Jaeger; Justin Leach; Raven M Osborn; Ann O Birmingham...
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with...
Early antibody treatment, inflammation, and risk of post-COVID conditions
Kelly A. Gebo; Sonya L. Heath; Yuriko Fukuta; Xianming Zhu; Sheriza Baksh; Allison G. Abraham; Feben Habtehyimer; David Shade; Jessica Ruff; Malathi Ram; Oliver Laeyendecker; Reinaldo E. Fernandez; Eshan U. Patel; Owen R...
Epigenetic memory of coronavirus infection in innate immune cells and their progenitors
Jin-Gyu Cheong; Arjun Ravishankar; Siddhartha Sharma; Christopher N. Parkhurst; Simon A. Grassmann; Claire K. Wingert; Paoline Laurent; Sai Ma; Lucinda Paddock; Isabella C. Miranda; Emin Onur Karakaslar...
Link to published version here
Preprint
Abstract
To understand the roles of acute phase viral dynamics and host immune responses in PASC, we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR. Participants self-collected nasal specimens up to 21 times...
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