il-1b

Cytokine profiles associated with persisting symptoms of post-acute sequelae of COVID-19 Ji-Soo Kwon, Euijin Chang, Hyeon Mu Jang, Ji Yeun Kim, Woori Kim, Ju Yeon Son, Junho Cha, Choi Young Jang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim...

Persistent Monocytic Bioenergetic Impairment and Mitochondrial DNA Damage in PASC Patients with Cardiovascular Complications Semo, Dilvin; Shomanova, Zornitsa; Sindermann, Jürgen; Mohr, Michael; Evers, Georg; Motloch, Lukas J.; Reinecke, Holger; Godfrey, Rinesh; Pistulli, Rudin Cardiovascular...

Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis Eltobgy, Mostafa M.; Zani, Ashley; Kenney, Adam D.; Estfanous, Shady; Kim, Eunsoo; Badr, Asmaa; Carafice, Cierra; Daily, Kylene; Whitham, Owen; Pietrzak, Maciej; Webb, Amy; Kawahara...

Towards precision medicine for (long) COVID Perspectives on pharmacotherapy and molecular mechanisms N. Baalbaki [Line breaks added] Abstract This thesis shed light on the complex and heterogeneous nature of (long) COVID. It contributed to the characterization of both acute COVID-19 and long...

Clinical, histopathological, and radiological characterization of post-acute sequelae of COVID-19 Anna Czech Abstract Numerous patients exhibit enduring symptoms following a Coronavirus Disease 2019 (COVID-19) infection, termed Post-Acute Sequelae of COVID-19 (PASC). The typical manifestations...

Exploring the shared mechanism of fatigue between systemic lupus erythematosus and myalgic encephalomyelitis/chronic fatigue syndrome: monocytic dysregulation and drug repurposing Daisi Zheng, Xiaolong Li, Qingmiao Zhu, Zhiyan Huang, Peicheng Wang, Ting Zhao [Provisionally accepted] Edit: Now...

Exploring the landscape of symptom-specific inflammatory cytokines in post-COVID syndrome patients Chafik Tilikete, Imen Zamali, Zeineb Meddeb, Ghassen Kharroubi, Soumaya Marzouki, Tarak Dhaouadi, Ahlem Ben Hmid, Samar Samoud, Yousr Galai, Selma Charfeddine, Leila Abid, Salem Abdessalem, Jihène...

An aberrant immune–epithelial progenitor niche drives viral lung sequelae Narasimhan, Harish; Cheon, In Su; Qian, Wei; Hu, Sheng’en Shawn; Parimon, Tanyalak; Li, Chaofan; Goplen, Nick; Wu, Yue; Wei, Xiaoqin; Son, Young Min; Fink, Elizabeth; de Almeida Santos, Gislane; Tang, Jinyi; Yao, Changfu...

Inflammatory Cytokines Can Induce Synthesis Of Type-I Interferon Nikhil Sharma; Xu Qi; Patricia Kessler; Ganes C. Sen Type I interferon (IFN) is induced in virus infected cells, secreted and it inhibits viral replication in neighboring cells. IFN is also an important player in many non-viral...

COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory cytokines/SGLT2 pro-oxidant pathway Ali Mroueh; Walaa Fakih; Adrien Carmona; Antonin Trimaille; Kensuke Matsushita; Benjamin Marchandot; Abdul Wahid Qureshi; Dal-Seong Gong; Cyril Auger; Laurent Sattler...

Abstract The long-term health effects of SARS-CoV-2, termed Post-Acute Sequelae of COVID-19 (PASC), are quickly evolving into a major public health concern, but the underlying cellular and molecular etiology remain poorly defined. There is growing evidence that PASC is linked to abnormal immune...

Diminished vasculogenesis under inflammatory conditions is mediated by Activin A Manohar-Sindhu, Sahana; Merfeld-Clauss, Stephanie; Goddard, Yana; March, Keith L.; Traktuev, Dmitry O. Severe inflammatory stress often leads to vessel rarefaction and fibrosis, resulting in limited tissue...

Proinflammatory Mediators, IL Interleukin-1β, TNF Tumor Necrosis Factor α, and Thrombin Directly Induce Capillary Tube Regression Gretchen M. Koller; Christopher Schafer; Scott S. Kemp; Kalia N. Aguera; Prisca K. Lin; Joshua C. Forgy; Courtney T. Griffin; George E. Davis OBJECTIVE: In this...

Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID Abstract While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of PASC presentations...

Exosome-associated Mitochondrial DNA is Elevated in Patients with ME/CFS and Stimulates Human Cultured Microglia to Secrete IL-1β https://www.researchsquare.com/article/rs-154011/v1 Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease that presents...

Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1β Abstract Abstract. Nijs J, Van Oosterwijck J, Meeus M, Lambrecht L, Metzger K, Frémont M, Paul L (Vrije Universiteit Brussel...

[This seems to be only very tenuously about ME/CFS] Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown etiology and without effective treatment options. The onset of ME/CFS is often associated with neuroinflammation following bacterial or...

Full title: Are Circulating FGF21 and NT-proBNP promising novel biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome? https://www.liebertpub.com/doi/abs/10.1089/ars.2020.8230

Paywalled at https://www.journalofinfection.com/article/S0163-4453(19)30027-1/fulltext