ido2

Measurement of Genetic Variations in ME/CFS Patients in the IDO2 Gene Encoding an Enzyme Metabolizing Tryptophan Edgar, Christina D.; Blair, Anna; Tate, Warren P. Genetic variations in the indoleamine 2,3-dioxygenase (IDO2) gene that are commonly found in the general population have been...

Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection Background Post-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression of the...

Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling [https://www.nature.com/articles/s41598-018-34166-4]

There are some issues and concerns around the IDO2 tryptophan trap hypothesis about ME. These are my current thought directions, and should not be considered scientific fact. Please comment, add links, agree or disagree, or move this post to somewhere better if you are a moderator. Concerns...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466478/ @Jonathan Edwards Given that people with MECFS apparently have mutations in IDO2--do you think using IDO2-specific mAb will work for MECFS as it apparently does for RA? Did this pan out for RA?

Background The metabolic trap hypothesis being investigated by the OMF is currently investigating IDO2, with the Severely Ill Big Data Project finding IDO2 mutations in the 20 patients ill with M.E. This question is about how someone can check if they have the mutations found based on genetic...

Gene mutation IDO2 Every ME/CFS patient has this mutation. Biochemists and Geneticists say IDO2 is not necessary, it doesn't have a function. Clearly not true as every patient has this mutation. We have hypothesis: No details yet but called 'Metabolic trap'. We are trying to prove...