gwas

Genetic Risk Variants for Multiple Sclerosis and Other Loci Linked to Intrathecal Immunoglobulin G Synthesis BACKGROUND AND OBJECTIVES Intrathecal synthesis of immunoglobulin G (IgG) is a key feature of multiple sclerosis (MS) and a prognostic marker for the disease course. Although previous...

Genome-wide association study of adolescent-onset depression Abstract Adolescent depression is a heritable psychiatric condition with rising global prevalence and severe long-term outcomes, yet its biological underpinnings remain poorly understood. We conducted the first genome-wide...

Genome-wide association studies of Long COVID and post-acute complications of SARS-CoV-2 in the UK Biobank Data The genetic foundations of post-COVID-19 conditions remains unclear. We performed two genome-wide association studies (GWAS) in UK Biobank COVID-19 positive individuals to identify...

Abstract Fibromyalgia is a common and debilitating chronic pain syndrome of poorly understood etiology. Here, we conduct a multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals (54,629 cases and 2,509,126 controls) from 11 cohorts, identifying the first 26 risk...

Global and Sex-Stratified Genome-Wide Association Study of Long COVID Based on Patient-Driven Symptom Recall We aimed to explore the global and sex-specific genetic variants associated with long COVID, as defined by patient-driven symptom recall. A 1-year cohort study of 2411 COVID-19 patients...

Complex Genetics and Regulatory Drivers of Hypermobile Ehlers-Danlos Syndrome: Insights from Genome-Wide Association Study Meta-analysis [Line breaks added] Background Hypermobile Ehlers Danlos syndrome (hEDS) is the most common subtype of EDS, a group of heritable connective tissue...

SLC45A4 is a pain gene encoding a neuronal polyamine transporter Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can...

GWAS highlights the neuronal contribution to multiple sclerosis susceptibility https://pmc.ncbi.nlm.nih.gov/articles/PMC11643295/ Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative disease affecting the brain and spinal cord. Genetic studies have identified many risk loci...

Large-scale genome-wide analyses of stuttering Hannah G. Polikowsky, Alyssa C. Scartozzi, Douglas M. Shaw, Dillon G. Pruett, Hung-Hsin Chen, Lauren E. Petty, Alexander S. Petty, Emily J. Lowther, Shu-Hsien Cho, Yao Yu, 23andMe Research Team, Sahar Mozaffari, Christy L. Avery, Kathleen Mullan...

Title: Multi-omic insights from a multi-ancestry genome-wide meta-analysis of ankylosing spondylitis reveal novel pathways of disease susceptibility Authors: Matthew Brown, Zhixiu Li, Xin Wu, Nicholas Harvey, Jose Garrido-Mesa, Xiaobing Wang, Zhihao Xu, Geng Wang, Helena Marzo-Ortega, Dennis...

Genome-wide study of somatic symptom and related disorders identifies novel genomic loci and map genetic architecture [Line breaks added] Abstract Somatic symptom and related disorders (SSRD) are characterized by a mixture of neurological and psychiatric features and include functional...

Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank, 2025, Pan Abstract Objectives: Widespread pain is a hallmark characteristic of fibromyalgia, commonly affecting older individuals. This study aimed to identify novel genetic...

Abstract: Background/Objectives: The aetiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a chronic and severe debilitating disease with a complex phenotype, remains elusive. Associations with infectious diseases and autoimmune and neuropsychiatric disorders have been...

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder Strom, Nora I. and 207 others Obsessive–compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis...

Abstract: If health impairments due to coronavirus disease 2019 (COVID-19) persist for 12 weeks or longer, patients are diagnosed with Post-COVID Syndrome (PCS), or Long-COVID. Although the COVID-19 pandemic has largely subsided in 2024, PCS is still a major health burden worldwide, and...

Preprint posted on MedRxiv, now posted with new title on SSRN, see post #4 Integrative Genome-Wide Association Studies of COVID-19 Susceptibility and Hospitalization Reveal Risk Loci for Long COVID Zhongshan Cheng Abstract Long COVID presents a significant public health challenge...

Full title: A comparison of genome-wide association analyses of persistent symptoms after Lyme disease, fibromyalgia, and myalgic encephalomyelitis – chronic fatigue syndrome Annemarie G. Hirsch, Anne E. Justice, Amy Poissant, Cara M. Nordberg, Navya S. Josyula, John Aucott, Alison W. Rebman &...

Abstract Background Postural orthostatic tachycardia syndrome (POTS) is a complex disorder with serious health consequences, while its etiology remains largely elusive. Objective The purpose of this study was to investigate the genetic landscape of POTS using genomic approaches in a unique...

Actively Protective Combinatorial Analysis: a Scalable Novel Method for Detecting Variants that Contribute to Reduced Disease Prevalence in High-Risk Individuals Jason Sardell; Sayoni Das; Krystyna Taylor; Colin Stubberfield; Andy Malinowski; Mark Strivens; Steve Gardner We present a novel...

Abstract: Major depressive disorder (MDD) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) frequently occur together; yet their causal relationship remains unclear. To investigate the potential genetic causal link between these conditions, we conducted a two-sample Mendelian...