ebv

Impaired control of autoimmunity increases pediatric multiple sclerosis risk in EBNA-1-seropositives and -seronegatives Abstract Multiple sclerosis (MS) is an autoinflammatory disease of the central nervous system (CNS). Epstein–Barr virus (EBV) encodes for EBNA-1 381-452 , which induces...

A pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity Abstract T and B cell-mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein-Barr virus (EBV) is a likely driver of MS, yet...

Long COVID shows IL-1 pathway dysregulation without a discrete circulating biomarker signature Abstract Long COVID (LC) is characterized by persistent and, often, disabling symptoms, yet its biological basis remains unclear. Multiple mechanisms, including immune dysregulation, endothelial...

EBV Reprograms B Cells in an Autoimmune-Like Fashion in Patients with COVID-19 Epstein-Barr virus (EBV) reprograms B cells in autoimmune disease. Reprogrammed EBV+ B cells activate nearby B and CD4+ T cells, via upregulated antigen presentation and costimulatory machinery, to drive autoimmune...

Persistent cytolytic CD8+ T cells recognize SARS-CoV-2 and herpesvirus epitopes in long COVID Highlights • Combinatorial tetramer deep-profiling of viral-specific T cells in long COVID (LC) • LC features more cytolytic CD8+ T cells against SARS-CoV-2, CMV, and EBV • Females with LC exhibit...

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease of unknown aetiology associated with chronic severe fatigue and neurological symptoms, including dizziness, sleep disturbances, cognitive impairment and pain. There are no reliable blood biomarkers available for...

Defective B cell tolerance in SLE lymph nodes underpins VH4-34 "clonal damnation" and PD-1+TOX+ autoreactive B cells expansion. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease driven by uncensored B and T cell autoreactivity. Understanding this pathogenic process has been...

Transgenic mouse-derived human monoclonal antibodies targeting EBV gp350 and gp42 provide basis for therapeutic development Highlights • Transgenic mice were used to make genetically human EBV mAbs against gp350 and gp42 • mAbs potently neutralize EBV infection by blocking receptor-ligand...

Immune-metabolic trajectories delineate subgroups in paediatric long COVID Most children and adolescents recover rapidly from SARS-CoV-2 infection, yet a subset develops paediatric long COVID (LC). How immune ontogeny shapes LC biology and heterogeneity remains unclear. We deeply phenotype a...

Full title: The composition of MDSC-subpopulations PMN-like, M-like, and e-like MDSC is associated with the severity of infectious mononucleosis in pediatric patients Abstract Background: Primary infection with the Epstein-Barr virus (EBV) in early childhood is often asymptomatic, whereas...

Comparing ME/CFS following mononucleosis with Long COVID Jason, Leonard A; Furst, Jacob; Katz, Ben Z Objectives Long COVID following SARS-CoV-2 and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) following infectious mononucleosis (IM) are examples of post-infectious chronic...

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients Abstract Chronic persistence of systemic symptoms after recovery from active CoVID-19 has become a significant disease burden, named post-CoVID syndrome...

https://www.tandfonline.com/doi/full/10.1080/10253890.2026.2638303 Research Article The association between hair cortisol levels, Epstein-Barr virus infections and chronic fatigue in adolescents Berit Elise Bergem Kongsnes , Tarjei Tørre Asprusten , Vegard Bruun Bratholm Wyller & Maria...

Background and Objectives: Post-COVID-19 syndrome (PCS), characterized by persistent fatigue, can develop after a SARS-CoV-2 infection. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, post-infectious condition marked by severe fatigue and post-exertional malaise. This...

Diminished EBV-Specific Humoral Immunity is Associated with Neuropsychiatric Long COVID Development up to 12 Months Post-COVID-19 Symptom Onset [Line breaks added] Abstract Infection with SARS-CoV-2 can lead to long COVID, a chronic multisystemic condition estimated to affect approximately...

Epstein Barr virus, infectious mononucleosis and associated diseases as contributors to the costs of intimate kissing Ewald, Paul W. [Line breaks added] Abstract When evaluating whether kissing is an evolutionary adaptation, fitness costs and benefits need to be considered. Any disease...

Abstract Multiple sclerosis (MS) occurs when the central nervous system (CNS) is damaged by misguided adaptive immune responses, likely caused by a combination of environmental factors in genetically susceptible individuals. A known prerequisite for disease is Epstein-Barr virus (EBV)...

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation The efficacy of B cell depletion therapies, and their association with Epstein-Barr virus (EBV), implicate B cells in the pathogenesis of multiple sclerosis (MS). In...

Epstein Barr viral shedding dynamics in saliva during acute SARS-CoV-2 infection BACKGROUND Epstein−Barr virus (EBV) establishes latency in most adults and can be reactivated under conditions of co-infection and immune dysregulation. COVID−19 has been associated with EBV reactivation...

SARS-CoV-2 Infection Is Associated With an Increased Risk of Hospital-Treated Infectious Mononucleosis due to EBV: National Register-Based Cohort Study There is evidence that persistent dysregulation of the immune system caused by SARS-CoV-2 infection may increase susceptibility to other...