discussion thread

My thanks to rvallee for pointing out that "brain fog" has no medical name and therefore no proper, medical recognition. I seem to have internalized the fact so deeply that the obvious had escaped me. The "fog" has been, for me, as bad as the lead overalls. If I could just stay in but still...

Does psychosomatic illness exist? We all know that ME/CFS is NOT psychosomatic. And we know that a lot of studies into psychosomatic stuff (like MUS stuff) are bullshit. But I would like to know, is there any good quality research indicating that psychosomatic illness exists? Any type of...

This thread has been split from Concerns about craniocervical instability surgery in ME/CFS ....I know you have a lot of pull on here @Jonathan Edwards, but I didn't know you didn't believe in MCAS being a real diagnosis. As I live in the States, I have to say that there seem to be a lot of...

Moderator note: This post has been copied and following posts moved from this thread: Epidemiological and clinical factors associated with post-exertional malaise severity in patients with ME/CFS. Ghali et al. 2020 ____________________ PEM studies always catch my attention, especially ones...

Threads about articles and people's experiences with LDN have been merged into this single thread. Medscape: Low-dose Naltrexone Explored as Option for Chronic Pain (by Miriam Tucker) Miriam Tucker's third article from the recent 2- day summit at the Bateman-Horne Center Low-dose Naltrexone...

Moderator note: This post has been copied and following posts moved from this thread: Concerns about craniocervical instability surgery in ME/CFS __________________________ Not really clear on how credible this statement is, at least in terms of POTS. I thought there were tachacardia and...

I’ve decided to take a closer look at the evidence for chronic Lyme disease. I’ve chosen to skip issues relating to the persistence of the bacterium Borrelia burgdorferi and the use of prolonged antibiotic therapy, to focus on basic epidemiology. The main question I wanted to answer is whether...

Threads have been merged Fatigue as presence of sensation or absence? This is another one of those posts where I try to describe some highly subjective symptom in the hopes of improving our understanding of the illness. I think that everyone knows the kind of fatigue where there is an intense...

Moderator note: This post has been copied and subsequent posts moved from this thread: Concerns about craniocervical instability surgery in ME/CFS _________________________________ Chronic Fatigue Syndrome is a such a vague diagnosis that it can cover many things since fatigue is such a common...

I’m after some information about scales which measure severity of disease in ME/CFS, in terms of functional impairment (mild vs severe). There seem to be several which measure symptom severity and, whilst there will likely be a correlation between symptom and disease severity, they’re not the...

I would like to use this thread for a discussion on the effects of a lack of blinding in randomized trials, something that frequently comes up in our discussions elsewhere on the forum. Ever since the new risk of bias (RoB 2) tool for Cochrane came out I’ve been trying to learn more about...

Does anyone know of research into sensory sensitivities in ME? (I know MERUK have something in motion, but is there anything already published?) Or anything that outlines possible causes?

Moderator note: This post and the next two have been copied, and subsequent posts moved from this thread: JAMA -"Advances in understanding the Pathophysiology of Chronic Fatigue Syndrome" by Anthony Komaroff Posts about sex ratio have been moved to a new thread: ME/CFS Epidemiology - sex...

All Having skimmed over contents over the past week, I can't see substantive difference between gulf war syndrome sufferers and being a pwME. I asked this due to its public policy and liability implications. Can anyone explain how gulf war syndrome is distinct from ME/CFS? I accept that there...

Thought it might be helpful to have a thread on the use of this scale. The HADS is often used in research into ME/CFS because it was, as is said, designed to measure anxiety and depression in patients who are physically ill. Back in 1990 Lewis & Wessely did a study on the usefulness of HADS to...

(This isn't really "news" but I didn't know where else to put this thread.) Firstly let me clarify that I am not talking about the bogus 'recovery' statistics that are propagated by the BPS lot. Rather, I am referring to hearsay that ive heard within the ME community (from people who are not...

This post and others on the thread have been copied or moved from this thread on MEAction Research Summary 2019 One example: The ME Action research summary suggests that a reduced blood volume has repeatedly been found. That seems to contrast with how the latest study on this topic summarized...

I’m wondering if anyone is aware of any appropriate mouse models of ME/CFS? I’m familiar with the Japanese model of putting the mice/rats in a layer of water, but that’s really a model of chronic stress, not ME/CFS. Are there any others?

I decided to start this thread based on the latest findings of the Whole Genome Sequencing webinar from SolveCFS. During the seminar a slide was shown related to Glycogen Storage Diseases -there are 14 types- and a specific mention was about GSD Type 13 for Enolase beta. I decided to start...

Has anyone had their complement levels tested? Is a low C3 relevant??? My C4 has come back at the bottom of the normal range, and my C3 is below the normal range.....